Shares of Orphazyme (NASDAQ: ORPH), a clinical-stage biopharmaceutical company, are getting hammered after the Food and Drug Administration (FDA) refused to approve an application for the company's lead candidate. The FDA began reviewing an application for Orphazyme's lead candidate arimoclomol last September as a potential treatment for a rare but life-threatening disease called Neimann-Pick Disease Type-C (NPC).
It was a punch that sent shockwaves through rugby and beyond
Duke has been stripped of a key role by King Charles ahead of major visit to African country
He was described as a 'giant in the local news industry and the entertainment world'
Baby Reindeer has taken the world by storm since its release – but fans have been devastated by the sudden and unexpected death of one of the show's key players
A bus crashed off a bridge and into the Moyka River in Saint Petersburg, Russia, on Friday, May 10, with local police saying around 20 people were on board.Local media reported that at least five people died, with four “seriously injured”. These figures had not been officially confirmed.The city’s governor, Alexander Beglov, said emergency services from various departments were on the scene.Local police said the circumstances that led to the bus being driven into the river were still being determined.This security footage shows the bus driving along the side of a building, swerving to hit a car, and then crashing into the river. Credit: Russian Ministry of Internal Affairs via Storyful
Meghan Markle and Prince Harry arrived in Nigeria on Friday morning following their secret reunion in London the day before. Get the details here…
Gemma Collins has revealed she was advised by doctors to terminate her pregnancy after they found out the baby was intersex, leaving her devastated and 'in shock'
The real reason King Charles won't see Prince Harry during his trip to England has been revealed by sources.
Katie Price has been served an eviction notice at her famous 'Mucky Mansion' home and must leave the property within days. It comes after it she was declared bankrupt for a second time
The Duke of Sussex was in London for the 10th anniversary of the Invictus Games at St Paul's Cathedral in London
Daniels met the onslaught with polite and unyielding confidence.
Prince Harry was in London to attend a service of thanksgiving at St Paul's Cathedral to mark the 10th anniversary of the Invictus Games and was greeted by hundreds of fans
Can my neighbour legally access my internet without permission in the UK?
Cheryl Baker, who won Eurovision in 1981 as part of Bucks Fizz, has given her verdict on the UK's act ahead of this weekend's grand final and says she hopes she's wrong
King Charles reportedly snubbed Prince Harry in London because he couldn't endorse a "hostile, rival royal operation."
President Biden was poised to run a strong campaign against Donald Trump on returning the US to normalcy, Fareed Zakaria writes. Polling shows that has gone off the rails, as voters seem concerned about his age and approach to the Israel-Hamas war in Gaza.
UK drivers could be breaking the Highway Code by driving while wearing sunglasses this summer
Julen Lopetegui expected to be appointed as successor in east London
News comes after a series of personal setbacks in presenter’s life
Tearful Jeremy Clarkson celebrated his big win against the council in Clarkson's Farm.
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