UK Markets closed
Budget 2021:

What the budget means for your taxes, housing, pensions and more

How announcements made by chancellor Rishi Sunak will impact your income and finances

2021 Pipeline Insights on Paranasal Sinus Cancer - ResearchAndMarkets.com

·5-min read

The "Paranasal Sinus Cancer - Pipeline Insight, 2021" drug pipelines has been added to ResearchAndMarkets.com's offering.

This report provides comprehensive insights about 5-10 companies and 5-10 pipeline drugs in Paranasal sinus cancer pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Symptoms

Symptoms can include blocked sinuses, pain in sinus areas, nosebleeds, lump inside the nose that does not heal, and swelling or other trouble with the eyes, such as double vision or the eyes pointing in different directions.

Diagnosis

Diagnosing Paranasal sinus cancer requires physical assessments of nose, face, and neck. Furthermore, clinicians also recommend screening procedures such as X-rays, MRI, CT scan, nasoscopy, laryngoscopy to view inside the nose for abnormal areas. Sometimes biopsy is also done to detect the presence of malignant cells inside the sinus cavity.

Treatment

Different types of treatments are available for patients with paranasal sinus cancer. The currently used treatments include surgery, radiation therapy, and chemotherapy which comprises of administration of several approved drugs such as cisplatin, docetaxel, methotrexate, and others.

Paranasal sinus cancer Emerging Drugs Chapters

This segment of the Paranasal sinus cancer report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Paranasal sinus cancer Emerging Drugs

Cabozantinib: Exelixis

Exelixis' lead drug candidate, Cabozantinib, is an orally administered small molecule receptor tyrosine kinase inhibitor that inhibits specific tyrosine kinases such as VEGFR-1, -2 and -3, KIT, TRKB, FLT-3, AXL, RET, MET, and TIE-2 and suppress metastases, and oncogeneses. Preclinical data demonstrated that Cabozantinib is used for the treatment of head and neck as well as paranasal sinus squamous cell cancer that has come back or spread to other places in the body and cannot be removed by surgery.

Motolimod: Celgene

Celgene drug motolimod is currently being evaluated for the treatment of Paranasal sinus cancer. Motolimod, a toll-like receptor 8 (TLR8) agonist, stimulates myeloid dendritic cells, monocytes, and natural killer cells in the blood and tumor microenvironment, inducing a proinflammatory immune response. In the phase I trial, Tumor immune modulation will be evaluated by counting the number of tumor infiltration CD8+ T cells before and after treatment.

Paranasal sinus cancer: Therapeutic Assessment

This segment of the report provides insights about the different Paranasal sinus cancer drugs segregated based on following parameters that define the scope of the report, such as:

Major Players in Paranasal sinus cancer

There are approx. 10+ key companies which are developing the therapies for Paranasal sinus cancer. The companies which have their Paranasal sinus cancer drug candidates in the mid to advanced stage, i. e. phase III and Phase II include, Exelixis and others.

Phases

This report covers around 10+ products under different phases of clinical development like

  • Late-stage products (Phase III)

  • Mid-stage products (Phase II and Phase I/II)

  • Early-stage products (Phase I/II and Phase I) along with the details of

  • Pre-clinical and Discovery stage candidates

  • Discontinued & Inactive candidates

  • Route of Administration

Paranasal sinus cancer pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

  • Cutaneous

  • Subcutaneous

  • Intravenous

  • Oral

  • Molecule Type

Products have been categorized under various Molecule types such as

  • Small molecules

  • Natural metabolites

  • Monoclonal antibodies

  • Product Type

Paranasal sinus cancer: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Paranasal sinus cancer therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Paranasal sinus cancer drugs.

Report Highlights

  • The companies and academics are working to assess challenges and seek opportunities that could influence Paranasal sinus cancer R&D. The therapies under development are focused on novel approaches to treat/improve Paranasal sinus cancer.

Key Questions Answered

Current Treatment Scenario and Emerging Therapies:

  • How many companies are developing Paranasal sinus cancer drugs?

  • How many Paranasal sinus cancer drugs are developed by each company?

  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Paranasal sinus cancer?

  • What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Paranasal sinus cancer therapeutics?

  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?

  • What are the clinical studies going on for Paranasal sinus cancer and their status?

  • What are the key designations that have been granted to the emerging drugs?

Key Players

  • Exelixis

  • Bristol-Myers Squibb

  • Eli Lily

  • S. L.A. Pharma AG

  • Celgene

For more information about this drug pipelines report visit https://www.researchandmarkets.com/r/yle3kc

View source version on businesswire.com: https://www.businesswire.com/news/home/20210122005341/en/

Contacts

ResearchAndMarkets.com
Laura Wood, Senior Press Manager
press@researchandmarkets.com

For E.S.T Office Hours Call 1-917-300-0470
For U.S./CAN Toll Free Call 1-800-526-8630
For GMT Office Hours Call +353-1-416-8900

Latest stories

  • Tottenham benefit from handball rule to claim valuable victory at Fulham

    Tosin Adarabioyo’s own goal earned Spurs victory as Fulham had a second-half equaliser ruled out following a VAR review.

  • UK's Johnson 'horrified' by Myanmar violence

    British Prime Minister Boris Johnson said on Thursday he was horrified by the recent violence in Myanmar and called for a restoration of democracy. "I'm horrified by the escalation of violence in Myanmar and the killing of pro-democracy protesters," Johnson said on Twitter. The United Nations said 38 people had been killed during Wednesday's demonstrations, the bloodiest day yet in a crackdown on opponents of last month's military coup.

  • Police Harass Youth Worker Who Monitors Police Harassment

    David Smith, 20, was stopped and searched by Metropolita Police officers in east London.

  • Securian Financial Introduces New Investment-Only Variable Annuity

    Securian Financial has launched MultiOption® Momentum, an investment-only variable annuity (IOVA) offering a distinctive combination of both indexed and variable investment options in a tax-deferred, variable annuity.

  • Uber Senior Vice President to Participate in Fireside Chat at Truist Technology, Internet, and Services Summit

    Uber Technologies, Inc. (NYSE: UBER) today announced that Andrew Macdonald, Senior Vice President and head of its Mobility segment, will participate in a fireside chat at the Truist Technology, Internet, and Services Summit on Wednesday, March 10, 2021. Mr. Macdonald is scheduled to appear at 10:30 am ET (7:30 am PT).

  • AM Best Assigns Issue Credit Rating to Aflac Incorporated’s New Senior Unsecured Notes

    AM Best has assigned a Long-Term Issue Credit Rating of "a-" to the newly issued senior unsecured notes of Aflac Incorporated (Aflac) (Columbus, GA) [NYSE: AFL]. The $400 million, 1.125% notes, due March 15, 2026, were issued as senior sustainability notes. The outlook assigned to the Credit Rating (rating) is stable. The existing ratings of Aflac and its subsidiaries are unchanged.

  • Why Square Stock Fell Today

    Shares of Square, Inc. (NYSE: SQ) tumbled today after the company announced that it would purchase a majority ownership stake in the music-streaming company, TIDAL. Jay-Z, who bought TIDAL just six years ago, will join Square's board of directors. Square said in a press release that it will pay a mix of cash and stock worth $297 million for TIDAL.

  • Clashes in Senegal kill one after arrest of opposition leader Sonko

    Senegalese police clashed with supporters of arrested opposition leader Ousmane Sonko on Thursday, leaving one person dead in the south of the country, a police official said. It was the first death confirmed in clashes since Sonko was arrested on Wednesday for disturbing public order as protests broke out ahead of his court appearance on a rape charge.Sonko, leader of the opposition Pastef party and former presidential candidate, is considered a key potential challenger for President Macky Sall in elections in three years.One person was killed in clashes on Thursday in Bignona town, in the southern Casamance region, the police official said."We still don't know the cause, it is under investigation," said the official who asked not to be identified.Four police were also injured in the fighting.Sonko's arrest has triggered the worst unrest seen in Dakar in years, in a West African country known for its stability.Dozens of students were still holed up in Dakar's Cheikh Anta Diop university on Thursday, where they threw concrete blocks at police, who responded with tear gas and stun grenades, an AFP reporter at the scene said.Sonko was to be transferred Thursday evening to a Dakar courthouse where his case will be heard by a judge. But his lawyers said the hearing had been postponed to Friday."Ousmane Sonko is now the subject of a warrant. He will be taken to the investigating magistrate tomorrow, willingly or by force," Abdoulaye Tall, one of his attorneys, told AFP.Senegalese regulatory authorities on Thursday also suspended the signal of two local television channels, Sen TV and Walf TV, accusing them of broadcasting "in loop" images of the unrest after Sonko's arrest.Popular with youthHundreds of people had followed his motorcade on Wednesday, sounding horns and singing before clashes erupted and Sonko was arrested before reaching the court.Interior Minister Antoine Felix Abdoulaye Diome said Sonko had been arrested over a ban on gatherings because of the coronavirus and violating a traffic plan put in place."Everyone has to comply. Others have done the same. I wonder why there would be an exception," he told RFM radio.Sonko also denies the rape charges filed against him last month by an employee at a salon where he received massages.A 46-year-old devout Muslim, Sonko is frequently critical of Senegal's ruling elite and is popular with young people.He accuses Sall of conspiring to sideline him ahead of the 2024 elections.Violence also broke out Wednesday in other areas including in Casamance, where Sonko's father is from and where he has a strong following.Sonko ran against the president in the 2019 vote, but finished third in a race that delivered the incumbent a second term.Presidents in the former French colony are limited to two consecutive terms, but Sall launched a constitutional review in 2016, raising suspicions he intends to run again.(AFP)

  • Richarlison header earns Everton third straight win at West Brom

    The Toffees moved into the top four with victory at The Hawthorns.

  • Equus Workforce Solutions Awards Incentive Funding to Develop and Expand Registered Apprenticeship Programs

    Equus Workforce Solutions (Equus) announces awards of more than $350,000 in incentive funding to expand Registered Apprenticeship Programs as part of their Intermediary for Registered Apprenticeships contract with the U.S. Department of Labor. A Registered Apprenticeship Program is an industry-driven, high-quality career pathway where employers can develop and prepare their future workforce, and individuals can obtain paid work experience, classroom instruction and a portable, nationally recognized credential.

  • Notice of Lead Plaintiff Deadline for Shareholders in the Athenex, Inc. Class Action Lawsuit

    The suit alleges defendants issued false statements concerning Athenex business and prospects, resulting in its stock trading at inflated prices.

  • It’s Now Costlier If You Want to Borrow Treasuries to Short Them

    (Bloomberg) -- The cost of borrowing U.S. Treasury 10-year notes continues to spiral higher despite record-size auctions, fueled by a growing pool of investors who want to bet on higher yields.After last week’s Treasury market selloff pushed 10-year and longer-maturity yields to the highest levels in a year, emboldening bond market bears, the interest rate on overnight cash loans backed by the newest 10-year note -- repurchase agreements, or repos -- plummeted below minus 3% for only the third time since the beginning of 2018, according to Scott Skrym of Curvature Securities LLC. That’s the threshold below which it’s cheaper to pay the regulatory fine for failing to return the collateral on time than it is to renew the loan. While next week’s auction of additional 10-year notes may alleviate the pressure on repo rates, Treasury yields resumed rising Thursday, suggesting that bearish bets have room to run. The move began when Federal Reserve Chairman Jerome Powell downplayed the increase in long-term borrowing costs. In unscripted comments on the economy and monetary policy, Powell waved off the idea that the central bank ought to extend the average maturity of its purchases of Treasury securities, as some Wall Street strategists have suggested.Next week’s auction “should help, but we have a week to go,” John Davies, U.S. interest-rate strategist at Standard Chartered Plc, said of the March 10 auction. “The intervening period could still be very volatile for Treasuries and the pressure in the repo market could well remain in place.”Read More: Why the U.S. Repo Market Blew Up and How to Fix It: QuickTakeLiquidity CrunchThe past week’s turmoil in Treasuries has been marked by a drop in liquidity, which has prompted borrowers to opt for the more-liquid current 10-year Treasury -- whose repo rate fell to minus 4% on Wednesday -- over older notes in the sector that would be cheaper to borrow. The negative interest rate means the investor lending cash to borrow the note ends up having to pay, instead of getting compensated, and it suggests there’s a large short position in the security. The general collateral repo rate, by contrast, closed at 0.03% Wednesday.Daily Treasury repo fails -- which become a cheaper option than covering a short position when the repo rate falls below negative 3% -- surged to $64 billion as of March 3, the highest in four months, according to DTCC. Meanwhile, the rate to borrow the 10-year security in the repo market has retreated Thursday to around minus 3.25% after trading at minus 3.95%, according to ICAP.Another illustration of high demand to borrow the newest 10-year note is that the Fed, which owns about $14.9 billion of the issue, has been lending it in large quantities to dealers. On Thursday, the size of the bid submissions to the bank dropped from previous sessions, and dealers were fully filled, New York Fed data show. Fails back to the central bank also declined, an indication that some short positions are being trimmed.Treasuries suffered their biggest monthly loss in four years in February, as 10- and 30-year yields climbed to their highest levels in more than a year, pricing in an economic recovery as the U.S. virus infection rate eased amid the vaccine rollout. While next week’s 10-year auction may alleviate the current repo situation, the context of record-size auctions to finance pandemic relief, which Federal Reserve purchases have only partially offset, means that “investors are positioning appropriately for higher rates,” Bank of America strategist Meghan Swiber said in a note.Adding to the crunch are yen-based investors. They have been liquidating older Treasury positions, according to traders in Asia, who asked not to be identified as they aren’t authorized to speak publicly. The impact in the repo market comes from how dealers absorbing the Japanese supply in old bonds -- those not used in benchmarks -- often sell current ones to hedge their positions.Supply AnnouncementThe first of two reopenings of the current 10-year note could ease some of the Treasury market ructions. The issue debuted in February at $41 billion, and the Treasury Department has indicated that both reopenings will be $38 billion, resulting in a $117 billion issue by mid-April. However, the Federal Reserve is likely to absorb about $2.4 billion of next week’s offering, according to Wrightson ICAP economist Lou Crandall, which would curb some of the supply coming to market.“There are lots of specials in the Treasury market, so that will be alleviated,” said Peter Chatwell, head of multi-asset strategy at Mizuho International Plc, referring to bonds that are in particularly high demand in the repo market. But “more Treasury supply certainly won’t make investors want to buy duration.”The past week has seen tepid demand for sovereign debt offerings from Indonesia to Japan and Germany. With bond markets sitting on a “powder keg,” ING analysts see U.S. 10-year yields eventually soaring to 2%.While Japanese investors, the largest foreign holders of U.S. government bonds, tend to be attracted to higher yields following any selloff, some don’t see demand roaring back.The selling from Japanese funds is “likely to continue” as long as there is no warning from U.S. officials about the recent rapid pace of increase in yields, said Shinji Kunibe, head of global fixed-income group at Sumitomo Mitsui DS Asset.(Adds Powell details in third paragraph and securities-lending operation details in seventh paragraph.)For more articles like this, please visit us at bloomberg.comSubscribe now to stay ahead with the most trusted business news source.©2021 Bloomberg L.P.

  • Ex-Fox News Women Slam Jesse Watters for Victim-Blaming Cuomo Harassment Accusers

    John Lamparski/GettyFox News’ resident macho man Jesse Watters—who built his professional reputation, such as it is, by stalking liberals on camera, many of them women, on behalf of his predatory boss Bill O’Reilly—received a rhetorical slap in the face Thursday for his recommendation that women solve the problem of workplace sexual harassment simply by slapping their male harassers.“I would suggest that women—and I’ve gotten in trouble for saying this before—you slap the man in the face. And you do it immediately,” Watters opined on Wednesday’s episode of The Five during a discussion of the sexual harassment and unwanted touching allegations against New York Gov. Andrew Cuomo. “Because if you wait too long, the politician feels like he can keep doing this, and it doesn’t matter if it comes out a year or three years later. Do it immediately. When he’s fresh.”Several former Fox News women, who received monetary settlements and left the company after being targeted by harassers at the Donald Trump-friendly channel, reacted to Watters’ prescription with withering disgust.“Women all across America are very pleased to have Jesse Watters mansplain to them,” former Fox News political analyst Julie Roginsky told The Daily Beast, “but Jesse Watters might have observed while working for two harassers [late Fox News Chairman Roger Ailes and O’Reilly] that women are already facing the risk of professional retaliation by not going along with the harasser’s wishes.”Roginsky—who left Fox News in 2017 after settling a sexual harassment and retaliation lawsuit against the company, Ailes and his deputy Bill Shine—added: “If the women got violent with the harasser their career would be over. Many are bound by forced arbitrations and NDAs at the start of their jobs. They couldn’t tell their stories. The better suggestion from Jesse is to put the onus on his fellow men to not harass women.”Ed Henry’s Accusers Say His Behavior Was an Open Secret at Fox NewsFormer Fox News anchor Gretchen Carlson, whose July 2016 sexual harassment lawsuit against Ailes resulted in his being ousted in disgrace, agreed.“Suggesting that women should slap their perpetrator is re-victimizing the victim in the sense they should fix the problem they have nothing to do with,” Carlson told The Daily Beast. “The responsibility to stop harassment, primarily a man’s issue, should not fall on a woman to fix it. It’s similar to other excuses that women should leave their jobs or move to another department rather than looking at the real problem. It’s another cover-your-ass reaction rather than working to fix the problem.”In a tweet, she added: “Not to mention how idiotic it is to assume slapping a predator would somehow change them. And that it should be up to the woman to slap instead of predatory to just not harass.”In an emailed response to The Daily Beast, Watters said he had been misunderstood: “This kind of predatory behavior needs to stop immediately and it’s 100% the harasser’s responsibility to stop it. My intention was to defend victims and hold inappropriate politicians accountable—any suggestion otherwise is a misinterpretation of what I said.”Other women who spoke to The Daily Beast about Watters’s remark—several of whom signed non-disclosure agreements as part of cash settlements of lawsuits—asked to remain anonymous in order to avoid potential retaliation by Fox News Media or its parent company Fox Corp.“It is simple to say ‘just slap him in the face,’ and while that might garner the woman short-term cheers, it would almost inevitably condemn her professional career, especially in broadcasting,” said one former Fox on-air personality. “If every man at Fox who made inappropriate comments was slapped at that moment, you would have a lot of red-faced men walking around the network. And, sadly, the women would never be allowed past security again to see.”This woman added: “It is odd to see Fox take such an aggressive position regarding Gov. Cuomo, rallying for him to resign. This, as Fox continues to put multiple hosts and contributors on air who have been proven to do the same if not worse than the accusations against Cuomo.”A second woman cited the 42-year-old Watters’ reported history of divorcing his then-wife Noelle in March 2019 after engaging in an extramarital affair with his 26-year-old associate producer, now-wife Emma DiGiovine. The officiant at their December 2019 wedding was then-Fox News anchor Ed Henry, who was fired last year after a Fox Business producer filed a graphic lawsuit accusing Henry of sexual abuse.“A man [Jesse Watters] who had an affair with a much younger woman at work really has no place to tell women how they should react professionally when abused at work,” this person said. “Violence is not an answer. It's usually the one thing women fear the most when their abusers are much larger, heavier and stronger than they are.”Fox News Airs Openly Racist Segment on Asian PeopleAttorney Douglas Wigdor, who has represented several Fox News accusers, told The Daily Beast: “It’s a classic rape myth that women should somehow use their physical power to ward off men who attack them, when the reality is that most women panic and freeze when sexually assaulted.”Wednesday evening was not the first time Watters has drawn widespread criticism for piggish comments about women. In April 2017, the Fox host delivered some not-so-subtle sexual innuendo about Ivanka Trump, remarking upon video of her speaking at a women’s rights conference, “I really liked how she was speaking into that microphone,” while gesturing towards his mouth and smirking. The next day, Watters denied the sexual undertones before announcing an abrupt “family vacation.”Meanwhile, a former Fox News staffer said: “I’d buy tickets to watch Jesse Watters slap his former boss Bill O’Reilly. What say you anchorman? Are you hiding under your desk? Bill used to always say ‘what say you?’ and ‘are you hiding under your desk’ when guests wouldn’t come on after his on-air challenge to duke it out with him. Jesse Watters has lacked the moral fortitude to stand with any of the courageous women of Fox News, all who lost their jobs after being sexually harassed where he is currently employed.”This woman added: “Now, in an incredible twist, he fancies himself the arbiter of sexual harassment. Only at Fox News could it get this perverse. But what else can we expect when the founder of Fox News, Rupert Murdoch, diminished decades-long sexual harassment coverup as nothing more than a 'little bit of flirting.’”—Diana Falzone was an on-camera and digital reporter for FoxNews.com from 2012 to 2018. In May 2017, she filed a gender discrimination and disability lawsuit against the network and settled, and left the company in March 2018. Along with Roginsky and Carlson, she co-founded Lift Our Voices, a nonprofit seeking to eradicate NDAs in the workplace used to conceal toxic workplace behavior.Read more at The Daily Beast.Get our top stories in your inbox every day. Sign up now!Daily Beast Membership: Beast Inside goes deeper on the stories that matter to you. Learn more.

  • Liverpool vs Chelsea LIVE: Latest score, goals and updates from Premier League fixture tonight

    Follow all the action live from Anfield

  • Addison Rae appears to break down in tears after hearing Bryce Hall cheating rumors

    Addison Rae and Bryce Hall are TikTok's most on-again-off-again couple. The post Addison Rae appears to break down in tears after hearing Bryce Hall cheating rumors appeared first on In The Know.

  • COVID‑19 Vaccination Eligibility Expands for Upcoming Florida Publix Pharmacy Appointments

    The eligibility requirements for individuals to receive a COVID-19 vaccine in Florida have expanded. Starting with appointments made during tomorrow’s scheduling opportunity, all Florida K-12 and child care teachers and personnel will be eligible to make an appointment at a Publix Pharmacy.

  • Mortgage rates dig in above 3%, but the worst may be over for now

    Rates are the highest since last summer, but experts think the increases will slow.

  • AM Best Revises Outlooks to Negative for James River Group Holdings, Ltd. and Subsidiaries

    AM Best has revised the outlooks to negative from stable and affirmed the Financial Strength Rating (FSR) of A (Excellent) and the Long-Term Issuer Credit Ratings (Long-Term ICR) of "a" of the rated operating subsidiaries of James River Group Holdings, Ltd. (JRG Holdings) [NASDAQ:JRVR]. In addition, AM Best has revised the outlook to negative from stable and affirmed the Long-Term ICR of "bbb" of JRG Holdings. JRG Holdings is domiciled in Pembroke, Bermuda, while its subsidiaries are based in Pembroke, Richmond, VA, and Raleigh, NC. (See below for a detailed listing of the subsidiaries.)

  • Join the Club! Stride Offers New Career Learning Experiences for High School Students

    As part of its expanded efforts to put middle and high school students on an early pathway to successful futures, Stride, Inc. (NYSE: LRN) today announced it has launched two new programs designed to help young people learn more about in-demand careers from industry experts. The Stride Nursing Club and Stride Industry Chats are new initiatives which introduce teens to various professions through a free, virtual speaker series.

  • Azul 3D announces Paul F. Decker as CEO

    Announcement of new CEO, Paul Decker