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Araris Biotech AG to Present at 13th Annual World ADC San Diego 2022

·2-min read
Araris Biotech AG
Araris Biotech AG

AU ZH, Switzerland, Aug. 31, 2022 (GLOBE NEWSWIRE) -- Araris Biotech AG, a company pioneering a proprietary antibody-drug conjugate (ADC)-linker technology, today announced that the company will present data on Araris’ linker technology at the 13th Annual World ADC Conference in San Diego. The poster presentation, titled, "Inducing complete and long-lasting tumor eradications of a nectin-4 ADC generated with a novel linker technology,” will be given on September 7, 2022, at 5:45 p.m. PT during the conference’s scientific poster session.

Presentation highlights:

  • Araris’ anti-Nectin-4 antibody-drug conjugate (ADC) showed superior activity to enfortumab-vedotin (Padcev®, EV) in head-to-head in vitro and in vivo studies

  • Araris’ linker technology was used to generate a highly homogenous and pure ADC within 24 hours with enfortumab as the targeting antibody and monomethyl auristatin E (MMAE) as payload

  • The Araris ADC was highly stable in multiple sera, as well as in circulation in rodents with no payload loss or deconjugation

  • At single payload dose of 10µg/kg, the Araris ADC induced a complete tumor regression for more than 100 days, while EV at the same dose showed only a short and transient tumor regression with no complete responses

"We look forward to attending this year’s World ADC conference and sharing this promising preclinical data with our colleagues,” said Philipp Spycher, Ph.D., Chief Executive Officer at Araris Biotech. “Our linker technology has demonstrated its ability to generate ADCs that show very high efficacy even at low dose levels, as well as high plasma stability, which gives these drug candidates the potential for an improved therapeutic index.”

About Araris Biotech AG
Araris Biotech AG is pioneering the development of its novel antibody-drug conjugate (ADC)-linker technology to enable efficient and precise production of ADCs. Its linker platform enables the attachment of any drug payload to ‘off the shelf’ antibodies, without the need for prior antibody engineering. The resulting ADCs have shown very high activity at low doses and an improved therapeutic index compared to multiple FDA-approved ADCs. Araris is a spin-off company from the Paul Scherrer Institute (PSI) and ETH Zurich.

For more information, please visit www.ararisbiotech.com or follow Araris on Twitter and LinkedIn.

Corporate Contact:
Philipp Spycher, PhD
Chief Executive Officer
info@ararisbiotech.com
www.ararisbiotech.com

Media Contact:
Veronica Eames
LifeSci Communications, LLC
veames@lifescicomms.com
646-970-4682