Villa have been well out of form of late, winning just one of their last six games, and the ongoing injury absence for Jack Grealish continues to hamper their efforts to find consistent form.
FOLLOW LIVE: Latest Aston Villa vs Man City updates
They are 11th in the table and a top-half finish would still represent a successful campaign for them, even if it comes after a significant drop-off from their form in the early stages of the season.
City have lost just once on the road all campaign and will be keen to put an FA Cup semi-final defeat behind them, which ended their hopes of a quadruple this season.
Here’s everything you need to know ahead of the game.
When is the match?
The game kicks off at 8:15pm on Wednesday, 21 April.
Where can I watch it?
The match will be shown live on Sky Sports Main Event and Sky Sports Premier League. Subscribers can stream the game via the Sky Go app. If you’re not a Sky customer you can grab a NOWTV Day Pass here to watch without a subscription.
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AVFC XI: Martinez, Cash, Konsa, Mings, Targett, McGinn, Luiz, Nakamba, Traore, Watkins, Ramsey.
MCFC XI: Ederson, Walker, Dias, Stones, Zinchenko, Gundogan, Rodri, Bernardo, Mahrez, Foden, Jesus.
Villa - 17/2
Draw - 21/5
City - 7/17
The away side should return to winning ways with a dominant performance, as long as they discover a clinical touch. Villa 0-2 City.