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While Marcos Reus and Mats Hummels both had injury scares in their Bundesliga fixture against VfB Stuttgart at the weekend, they are both likely to be fit for the match. This is great news for the hosts as they have a lot to do after suffering a 2-1 defeat in the first leg.
CHAMPIONS LEAGUE LIVE: Latest Dortmund vs Man City updates
Meanwhile, City will see the return of all the players Pep Guardiola rested at the weekend including Kevin De Bruyne and Phil Foden - the two scorers from the first leg.
Here is everything you need to know about the tie.
When is it?
The match will kick off at 8pm GMT on Wednesday, April 14.
How can I watch it?
The fixture will air live on BT Sport 3. Subscribers can also stream the action live on the broadcaster’s website and app.
Dortmund XI: Hitz, Guerreiro, Hummels, Akanji, Morey, Can, Dahoud, Bellingham, Knauff, Reus, Haaland
Man City XI: Ederson, Walker, Dias, Stones, Zinchenko, Rodrigo, Gundogan, De Bruyne, Mahrez, Bernardo, Foden
Man City: 15/8
City could have more firepower with their rested players raring to go and they will want to get their side back to winning ways after they fell to defeat against Leeds United at the weekend. Despite Dortmund having star quality in Haaland, it won’t be enough to overcome the lead City already have. Dortmund 1-3 Manchester City (agg 2-5).