Hudson-Odoi was substituted at half-time of Chelsea’s goalless draw with Manchester United on Sunday and later emerged with strapping on his leg.
Tuchel had hoped Thiago would also be involved for such a key fixture – but the club’s medical staff have advised to take a cautious approach to the Brazilian’s return.
Elsewhere, Timo Werner leads the line while Ben Chilwell starts on the left flank, with Reece James on the right.
Chelsea XI: Mendy, Azpilicueta, Christensen, Rudiger, James, Kante, Jorginho, Chilwell, Ziyech, Mount, Werner
Subs: Arrizabalaga, Alonso, Pulisic, Zouma, Kovacic, Giroud, Hudson-Odoi, Havertz, Emerson Palmieri
Injury list: Thiago Silva
Doubts: Tammy Abraham