Stapleton, 43, took the award for album of the year at Sunday's star-studded country music awards show for his album Starting Over. Clay Walker presented the award.
"We worked really hard to make music. And we think a lot about it," Stapleton said, before thanking his wife Morgane and album collaborators. "It means a lot. It really does."
Check out PEOPLE's full ACM Awards coverage to get the latest news on one of country music's biggest nights.
Stapleton accepted his ninth ACM trophy and after he performed "Maggie's Song" alongside Miranda Lambert, who stepped in because his wife and frequent collaborator Morgane had a "prior doula commitment."
Stapleton was also up for the entertainer of the year title, which Luke Bryan won.
The AMC Awards are airing live from Nashville Sunday from 8-11 p.m. ET on CBS and Paramount +.