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FTSE 100 movers: Astrazeneca hit by rival success, Centrica higher on takeover preparations

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LONDON (ShareCast) - Astrazeneca (NYSE: AZN - news) was trading lower after the results of a study showed US rival Merck (Other OTC: MKGAF - news) 's diabetes drug met heart-safety requirements. The British drug-maker's own treatment for the disease was recently required by US authorities to provide information about the risk of heart failure. Standard Chartered (Other OTC: SCBFF - news) was in the red as it published sinking total revenues, which fell 4% to $4.4bn, a 6% miss against consensus forecasts of $4.7bn "We think that STAN's Q1 2015 IMS offers a preview of the unpalatable impact of planned de-leveraging," Investec (LSE: INVP.L - news) said in a note.

Centrica (LSE: CNA.L - news) surged as its chairman was quoted saying the company has made preparations in the event of a takeover offer.

BP was trading higher despite posting an underlying replacement cost profit decline for the three months to end-March. In Tuesday's trading statement, the oil giant said profit for the last quarter came in at $2.6bn compared with $3.2bn for the same period in 2014.

Costa Cofee and Premier Inn owner Whitbread (LSE: WTB.L - news) made gains as it served up impressive results for the year to 26 February. Revenue rose and underlying profits before tax were both higher, leading to a 19.4% increase in earnings to 213.67p per share, well ahead of the consensus forecast.

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Wealth management group St James's Place was among the risers as it posted a 22% increase in funds under management to £55.8bn in its latest interim statement.

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