Global Chimeric Antigen Receptor (CAR) T-Cell Therapy Market Research & Developments, 2018-2020 & 2021-2026
Dublin, Dec. 17, 2021 (GLOBE NEWSWIRE) -- The "Current Research & Development Status of Chimeric Antigen Receptor (CAR) T-Cell Therapy" report has been added to ResearchAndMarkets.com's offering.
The global market for chimeric antigen receptor (CAR) T-cell therapy is estimated to grow from $1.5 billion in 2021 to reach $7.6 billion by 2026, at a compound annual growth rate (CAGR) of 39.1% during 2021-2026.
The North American market for CAR T-cell therapy is estimated to grow from $751.5 million in 2021 to reach $3.5 billion by 2026, at a CAGR of 35.8% during 2021-2026.
The Asia-Pacific market for CAR T-cell therapy is estimated to grow from $228.9 million in 2021 to reach $2.1 billion by 2026, at a CAGR of 56.0% during 2021-2026.
Descriptive company profiles of the leading industry players, including AstraZeneca, Bristol Myers Squibb, Gilead Sciences, Novartis AG, F. Hoffmann-La Roche and Takeda Pharmaceutical Co., Ltd.
CAR T-Cell Design and Evolution
Chimeric antigen receptors (CARs, also known as chimeric immunoreceptors, chimeric T-cell receptors, artificial T-cell receptors or CAR-T) are engineered receptors that graft an arbitrary specificity onto an immune effector cell (T cell). Typically, these receptors are used to graft the specificity of a monoclonal antibody onto a T-cell, with the transfer of their coding sequence facilitated by retroviral vectors. The receptors are called chimeric because they are composed of parts from different sources.
FDA Product Approvals
There are five chimeric antigen receptor (CAR) T-cell therapies currently approved by the U.S. FDA. In March 2021, Bristol Myers Squibb launched its FDA-approved Abecma (idecabtagene vicleucel), a cell-based gene therapy to treat adult patients with multiple myeloma.
In February 2021, Bristol Myers Squibb launched Breyanzi (lisocabtagene maraleucel) after receiving FDA approval for its commercialization in the U.S. market. Breyanzi is a cell-based gene therapy to treat adult patients with certain types of large B-cell lymphoma.
In July 2020, Kite Pharma, a subsidiary of Gilead Sciences, launched Tecartus after receiving FDA approval for its commercialization in the U.S. market. Tecartus (brexucabtagene autoleucel, formerly KTE-X19), is the first and only approved chimeric antigen receptor (CAR) T-cell therapy for the treatment of adult patients with relapsed or refractory mantle cell lymphoma (MCL).
On Aug. 30, 2017, Novartis announced that the U.S. FDA had approved Kymriah (tisagenlecleucel) suspension for intravenous infusion, formerly CTL019, the first chimeric antigen receptor (CAR) T-cell therapy, for the treatment of patients up to 25 years of age with B-cell precursor acute lymphoblastic leukemia (ALL) that is refractory or in second or later relapse.
On Oct. 18, 2017, the U.S. FDA approved Yescarta (axicabtagene ciloleucel) (Kite Pharma Inc.), a cell-based gene therapy, for the treatment of adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy, including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, primary mediastinal large B-cell lymphoma, high-grade B-cell lymphoma and DLBCL arising from follicular lymphoma. Yescarta is not indicated for the treatment of patients with primary central nervous system lymphoma. It is a CD19-directed genetically modified autologous T-cell immunotherapy.
Key Topics Covered:
Chapter 1 Introduction
Chapter 2 Summary and Highlights
CAR T-Cell Design and Evolution
FDA Product Approvals
Market Analysis
Clinical Applications of CAR T-Cell Therapy
CARs for Tumors of the Hematopoietic and Lymphoid Tissues
CAR T-Cell Therapy for Solid Tumors
Barriers to Research and Product Development
Clinical Trials
Chapter 3 Introduction to Chimeric Antigen Receptor (CAR) T-Cell Therapy
Introduction
A Brief History of CAR T-Cell Therapy Development
Antigens
Exogenous Antigens
Endogenous Antigens
Autoantigens
Tumor Antigens
Cluster of Differentiation
Lymphocytes
B Cells
T Cells
Adoptive Cell Transfer (ACT) Technologies
Tumor-Infiltrating Lymphocytes (TILs)
T-Cell Receptors (TCRs)
Chimeric Antigen Receptors (CARs)
Chapter 4 Impact of COVID-19 on the Market
Overview
Outlook
Chapter 5 Market Dynamics
Market Dynamics
Selected Drivers of the Global CAR T-Cell Market
Trends
Selected Restraints of the Global CAR T-Cell Market
Chapter 6 Current Production Methods, Latest Technological Advances and Future Direction
Production of CAR T Cells
Stage 1: Leukapheresis and T-Cell Isolation
Stage 2: T-Cell Activation, Transduction and Modification of CAR T Cells
Stage 3: Expanding Modified CAR T Cells
Overcoming CAR T-Cell Manufacturing Challenges
Latest Advances in Production Processes
Closed, Automated Production Systems
End-to-End Production Systems and Solutions
Key Technologies Used in the Manufacturing Stage
Chapter 7 Clinical Trials on CAR T Cells and Related Technologies
Introduction
Clinical Trials Being Conducted Globally
Distribution of CAR T-Cell Trials in the U.S.
Distribution of CAR T-Cell Clinical Trials in China
Chapter 8 Cancer Demographics: A Global Summary
Cancer: The Disease
Epidemiology by Cancer Type/Site
Global Cancer Incidence
Global Cancer Prevalence, 2020
Global Cancer Mortality Overview
Cancer Epidemiology by Region
Global Cancer Burden and Worldwide Cancer Risk Factors
Tobacco Use and Statistics
Alcohol Abuse and Cancer Statistics
Obesity and Cancer Statistics
Infectious Diseases and Cancer
Inherited Genes: Diseases and Cancer
Sun, Ultraviolet Radiation and Cancer
Hormones and Cancer
Chapter 9 Global CAR T-Cell Market Analysis
Yescarta
Tecartus
Kymriah
Breyanzi
Abecma
Chapter 10 Regional Analysis
Chapter 11 Regulatory and Legislative Requirements
Mutual Recognition Procedure (MRP)
Decentralized Procedure (DCP)
Centralized Procedure (CP)
Published Guidelines on Production and Testing of Cell-Based Therapies
Chapter 12 Patent Review/New Developments
Complexities of the Patents and Patent Applications for Biotechnology and Pharmaceutical Companies
Anticipated Increase in Patent Litigation on Customized Patient Treatments
Company Specific Intellectual Property and Patent Information
Amgen
Avacta Life Sciences Ltd.
Bellicum Pharmaceuticals Inc.
Bluebird Bio
Celgene Corp.
Cellectis
Celyad SA
Editas Medicine Inc.
Eureka Therapeutics Inc.
Gilead Sciences Inc.
iCell Gene Therapeutics
Juno Therapeutics Inc. (A Celgene Co.)
Mustang Bio Inc.
Noile-Immune Biotech
Novartis AG
Chapter 13 Global Competitive Market Landscape
Global CAR T-Cell Market Share Analysis
Market Share Analysis
Product Launches
Strategic Initiatives
Mergers and Acquisitions
Chapter 14 Company Profiles
Abbvie Inc.
Amgen
AstraZeneca
Avacta Life Sciences Ltd.
Bellicum Pharmaceuticals
Bluebird Bio
Bristol Myers Squibb
Cellectis
Celyad SA
Editas Medicine Inc.
Eureka Therapeutics Inc.
Formula Pharmaceuticals Inc.
Gilead Sciences
F. Hoffman-La Roche AG
Icell Gene Therapeutics
Mustang Bio Inc.
Noile-Immune Biotech
Novartis AG
Protheragen Inc.
Puretech Health
Servier Laboratories
Takeda Pharmaceuticals
Transgene SA
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