Draper, who married the popular TV face 16 years ago, spent over 12 months in hospital before returning to their family home in April, where he needs around-the-clock assistance.
For the latest episode of his Life Stories interviews, which aired on Sunday (5 December) on ITV, Piers Morgan specifically asked what the virus had done to Derek.
"It's devastated him. From the top of his head to the tip of his toe," she revealed.
"His digestive system, his liver, his kidneys, his heart, his nervous system. We're pretty sure that the inflammation did pass through the brain. He still can't communicate, he still has issues with mobility.
"Fundamentally, he's in a terrible state. Look, he's alive, Piers."
Garraway, who must also take care of their kids Darcy and Billy, went on to share her hopes for a brighter future.
"It does feel as though I walked through a fiery furnace or fell down a rabbit hole. The world went dark and still looking for the light at the end of the tunnel, really," she said.
Further into their chat, the host referenced a heartwarming personal moment he'd had with Derek.
"We had a moment last night when I rang you about this interview. Without warning, you said to me, 'Why don't you talk to Derek?' and Derek replied when you said it was me, very loud, clear, 'Hello'," Morgan shared.
"And I said a few things to him and at the end he said, 'Thank you'. I was stunned."
Garraway replied: "Well, so were we. The carers that were with me at the time burst into tears. I mean, I don't want to suggest you're a healer Piers but it was a remarkable moment.
"It's moments like that that make you realise that he is in there."
For the latest advice and information on Coronavirus, visit the NHS website.
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