The champions have struggled for form in the league recently but will look to turn it around ahead of manager Jurgen Klopp’s 200th game in charge of the club.
However, United will be hoping to go six points clear with a win at Anfield as they try to inflict a first home defeat on Liverpool in the league since April 2017.
Ole Gunnar Solskjaer’s side are unbeaten in their last 15 away league games since losing to the Reds almost a year ago.
Here’s everything you need to know about the match:
When is it?
The fixture will kick-off at 4:30pm GMT at Anfield.
How can I watch it?
The match is live on Sky Sports Premier League, with coverage starting from 4pm GMT.
Liverpool: Alisson; Alexander-Arnold, Henderson, Fabinho, Robertson; Thiago, Wijnaldum; Shaqiri, Firmino, Mane; Salah
Manchester United: De Gea; Wan-Bissaka, Lindelof, Maguire, Shaw; Fred, McTominay; Rashford, Fernandes, Pogba; Martial
Manchester United: 13/5
This is the biggest Premier League fixture of the season so far, and it could go either way – one moment of brilliance by any of the individual superstars could win the game for their respective club. However, I think it could be quite scrappy as neither side wants to lose, and they settle for a draw. 1-1.