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Following their midweek thumping of Wolves, City have won 21 consecutive matches and appear to be unstoppable.
They find themselves with the opportunity to move 17 points clear of the Red Devils, who have been poor recently.
United are without a goal in their last three matches, drawing 0-0 with Real Sociedad, Chelsea and Crystal Palace.
Here’s everything you need to know about the match:
How can I watch it?
The match is live on Sky Sports Premier League and Main Event with coverage starting from 4pm GMT.
When is it?
The fixture will kick-off at 4:30pm GMT at the Etihad Stadium.
Manchester City: Ederson, Cancelo, Dias, Stones, Zinchenko, Rodrigo, Gundogan, De Bruyne, Mahrez, Sterling, Jesus
Manchester United: Henderson, Wan-Bissaka, Lindelof, Maguire, Shaw, Fred, Fernandes, McTominay, James, Rashford, Martial
Manchester City: 4/9
Manchester United: 6/1
Manchester United are struggling, and while they usually turn up against Manchester City – particularly at the Etihad – this match feels like it’s only going one way. 2-1 City.