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The Red Devils have watched as their rivals have run away with the title as their own season fell away with dismal draws against smaller clubs.
Ole Gunnar Solskjaer’s side are now without a goal in their last three matches in all competitions, while Manchester City put four past Wolves on Tuesday night.
A win would send Pep Guardiola’s team 17 points clear of their city rivals – a surely insurmountable lead at this stage in the season.
Here’s everything you need to know about the match:
When is it?
The fixture will kick-off at 4:30pm GMT at the Etihad Stadium.
How can I watch it?
The match is live on Sky Sports Premier League and Main Event with coverage starting from 4pm GMT.
Manchester City: Ederson, Cancelo, Dias, Stones, Zinchenko, Rodrigo, Gundogan, De Bruyne, Mahrez, Sterling, Jesus
Manchester United: Henderson, Wan-Bissaka, Lindelof, Maguire, Shaw, Fred, Fernandes, McTominay, James, Rashford, Martial
Manchester City: 4/9
Manchester United: 6/1
Manchester United are struggling, and while they usually turn up against Manchester City – particularly at the Etihad – this match feels like it’s only going one way. 2-1 City.