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An Edinson Cavani strike and a Jesus Vallejo own goal helped United defeat Granada on Thursday and advance to the Europa League semi-finals.
The Red Devils have won four successive matches in all competitions, including a 3-1 win at Spurs in their last league match.
Meanwhile, Burnley will be hoping to stun Ole Gunnar Solskjaer’s team after back-to-back defeats by Southampton and Newcastle in the league.
Here’s everything you need to know about the match:
When is it?
The fixture will kick-off at 4pm GMT at Old Trafford.
How can I watch it?
The match is live on Sky Sports Premier League and Main Event with coverage starting from 3:30pm GMT.
Manchester United: Henderson, Wan-Bissaka, Lindelof, Maguire, Shaw, Fred, McTominay, Greenwood, Fernandes, Pogba, Rashford
Burnley: Peacock-Farrell, Lowton, Tarkowski, Mee, Taylor, Gudmundsson, Brownhill, Westwood, Cork, McNeil, Wood
Manchester United: 4/11
Manchester United are in dangerous form and I think they could get a few goals against Burnley, who have lost their way a little recently. 3-0 Manchester United.