The Red Devils survived their trip to Anfield in the Premier League last weekend, and sit two points clear at the top of the Premier League.
Ole Gunnar Solskjaer’s side have established themselves as true title contenders, helped by Paul Pogba finding form close to his best, but they will be keen to impress against the Reds in the cup as their boss searches for his first piece of silverware in charge at Old Trafford.
Liverpool will be hoping that the cup can bring the best back out of a team that have struggled to find the net of late.
Since their 7-0 win over Crystal Palace over a month ago, the Reds have scored a single league goal – in a 1-1 draw at home to West Brom – while only winning one match, a 4-1 triumph over a youthful Aston Villa in the previous round.
This could prove to be a difficult test for Jurgen Klopp’s side, who not only lost to Burnley at home this week but also have struggled at Old Trafford in recent years.
United are unbeaten in their last seven home games against Liverpool, accumulating three wins in a run that stretches back to March 2014.
Here’s everything you need to know about the match:
When is it?
The fixture will kick-off at 5pm GMT at Old Trafford.
How can I watch it?
The match is live on BBC One and BBC One HD, with coverage starting from 4:30pm GMT.
What was the team news?
Dean Henderson and Alex Telles could be handed starts for United, but Ole Gunnar Solskjaer will still field a strong team – so Bruno Fernandes, Harry Maguire and Edinson Cavani are all in line to play once more.
Mohamed Salah and Roberto Firmino are set to return to the starting line-up while Sadio Mane will be rested, but Jordan Henderson could miss out with a muscle injury. Diogo Jota and Naby Keita are out.
Manchester United: Henderson; Wan-Bissaka, Lindelof, Maguire, Shaw; McTominay, Pogba; Greenwood, Van de Beek, Rashford; Cavani
Liverpool: Alisson; Alexander-Arnold, R. Williams, Fabinho, Robertson; Thiago, Wijnaldum, Milner; Jones, Salah, Firmino
Manchester United: 8/5
Liverpool are criminally out of form, particularly after the home loss to Burnley, while Manchester United continue to grind out favourable results. Both sides will go for the win in a game that could define their seasons, for better and worse, but I think the home side will prevail. Manchester United 1-0 Liverpool.