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* FTSE 100 up 0.1%, FTSE 250 down 0.2%
* AstraZeneca biggest boost to FTSE 100
* Ashtead rises after annual results
* Focus shifting to Fed policy meeting
June 18 (Reuters) - London's FTSE 100 edged higher on Tuesday with tool hire firm Ashtead gaining after an upbeat earnings report and miners boosted by a rise in copper prices driven by expectations of a global shortfall in production.
The miner-heavy main index was up 0.1% while the FTSE 250 midcap index lost 0.2% by 0708 GMT.
Ashtead rose nearly 3%, topping the FTSE 100 leader-board, while miners were up 1% as a key mine in Chile halved output due to a strike.
Drugmaker AstraZeneca was the biggest boost to the FTSE 100 with a 1.1% rise after its cancer medicine Lynparza was approved as a first-line maintenance treatment for a type of advanced ovarian cancer by the European Commission. Rival GlaxoSmithKline also climbed.
Market focus is gradually shifting to a two-day meeting of the U.S. Federal Reserve, with market pricing showing investors expect Wednesday's policy statement to open the way to a cut in interest rates by the central bank next month. (Reporting by Muvija M in Bengaluru; editing by Patrick Graham)