Yahoo Finance Pfizer's (PFE) Talazoparib Emerges Superior in EMBRACA Study
Pfizer Inc. PFE announced superiority of its breast cancer candidate – talazoparib – over chemotherapy in improving progression free survival (“PFS”) in a phase III study, EMBRACA.
Talazoparib is an investigation dual-mechanism poly ADP ribose polymerase (“PARP”) inhibitor. The company will present the data from the study at the 2017 San Antonio Breast Cancer Symposium.
Shares of Pfizer have gained 9.3% in the past six months, outperforming the industry’s rise of 4.4% in that period.
The EMBRACA study evaluated talazoparib as a single agent in patients with germline BRCA-positive breast cancer who have received prior chemotherapy treatment. The candidate achieved a significant reduction of 46% in the risk of disease progression as the median PFS was 8.6 months in the talazoparib arm versus 5.6 month in the chemotherapy arm.
Moreover, 62.6% of patients in talazoparib arm achieved complete or partial response against 27.2% of patients receiving chemotherapy.
PARP inhibition is a new targeted therapy, which inhibits repair of the DNA of the cell, thus destroying the cell. The label expansion application of AstraZeneca’s AZN PARP inhibitor, Lynparza, is under review in the United States. Meanwhile, Clovis Oncology, Inc. CLVS has collaborated with Bristol-Myers Squibb Company BMY to develop its PARP inhibitor in combination with the latter’s PD-1 immune checkpoint inhibitor, Opdivo, in breast cancer.
Apart from talazoparib, Pfizer is also developing its key drug, Ibrance for treating advanced or high-risk early breast cancer. Ibrance is currently approved for HER2-negative advanced or metastatic breast cancer.
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Pfizer carries a Zacks Rank #3 (Hold). You can see the complete list of today’s Zacks #1 Rank (Strong Buy) stocks here.
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