Shire plc : Block listing Interim Review

BLOCK LISTING SIX MONTHLY RETURN

May 23, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG)

Name of applicant:		Shire plc
Name of scheme:		Shire Sharesave Scheme
Period of return:	From:	November 23, 2017	To:	May 22, 2018
Balance of unallotted securities under scheme(s) from previous return:		163,520
Plus: The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):		Nil
Less: Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):		4,132
Equals: Balance under scheme(s) not yet issued/allotted at end of period:		159,388

Name of applicant:		Shire plc
Name of scheme:		Shire Portfolio Share Plan
Period of return:	From:	November 23, 2017	To:	May 22, 2018
Balance of unallotted securities under scheme(s) from previous return:		270,534
Plus: The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):		Nil
Less: Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):		101,940
Equals: Balance under scheme(s) not yet issued/allotted at end of period:		168,594

Name of applicant:		Shire plc
Name of scheme:		Shire Employee Stock Purchase Plan
Period of return:	From:	November 23, 2017	To:	May 22, 2018
Balance of unallotted securities under scheme(s) from previous return:		237,698
Plus: The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):		Nil
Less: Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):		Nil
Equals: Balance under scheme(s) not yet issued/allotted at end of period:		237,698

Name of applicant:		Shire plc
Name of scheme:		Shire Long Term Incentive Plan 2015
Period of return:	From:	November 23, 2017	To:	May 22, 2018
Balance of unallotted securities under scheme(s) from previous return:		2,498,571
Plus: The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):		Nil
Less: Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):		637,589
Equals: Balance under scheme(s) not yet issued/allotted at end of period:		1,860,982

Name of applicant:		Shire plc
Name of scheme:		Shire Global Employee Stock Purchase Plan
Period of return:	From:	November 23, 2017	To:	May 22, 2018
Balance of unallotted securities under scheme(s) from previous return:		800,783
Plus: The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):		Nil
Less: Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):		338
Equals: Balance under scheme(s) not yet issued/allotted at end of period:		800,445

Name of applicant:		Shire plc
Name of scheme:		Baxalta Exchange Awards
Period of return:	From:	November 23, 2017	To:	May 22, 2018
Balance of unallotted securities under scheme(s) from previous return:		17,230,339
Plus: The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):		Nil
Less: Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):		3,620,967
Equals: Balance under scheme(s) not yet issued/allotted at end of period:		13,609,372

Name of applicant:		Shire plc
Name of scheme:		Combined block listing in respect of the Shire Portfolio Share Plan, the Shire Long Term Incentive Plan 2015 and the Shire Global Employee Stock Purchase Plan.
Period of return:	From:	November 23, 2017	To:	May 22, 2018
Balance of unallotted securities under scheme(s) from previous return:		3,000,000
Plus: The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):		Nil
Less: Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):		Shire Portfolio Share Plan: Nil Shire Long Term Incentive Plan 2015: Nil Shire Global Employee Stock Purchase Plan: Nil
Equals: Balance under scheme(s) not yet issued/allotted at end of period:		3,000,000

Sarah Rixon
Company Secretarial Assistant

For further information please contact:

Investor Relations
Christoph Brackmann	christoph.brackmann@shire.com	+41 795 432 359
Sun Kim	sun.kim@shire.com	+1 617 588 8175
Robert Coates	rcoates@shire.com	+44 203 549 0874
Media
Katie Joyce	kjoyce@shire.com	+1 781 482 2779

NOTES TO EDITORS

About Shire

Shire is the global biotechnology leader serving patients with rare diseases and specialized conditions. We seek to push boundaries through discovering and delivering new possibilities for patient communities who often have few or no other champions. Relentlessly on the edge of what`s next, we are serial innovators with a diverse pipeline offering fresh thinking and new hope. Serving patients and partnering with healthcare communities in over 100 countries, we strive to be part of the entire patient journey to enable earlier diagnosis, raise standards of care, accelerate access to treatment, and support patients. Our Rare Disease and Neuroscience divisions support our diverse portfolio of therapeutic areas, including Immunology, Hematology, Genetic Diseases, Internal Medicine, Ophthalmics, Oncology, and neuropsychiatry disorders.

Championing patients is our call to action - it brings the opportunity - and responsibility - to change people`s lives.

www.shire.com

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Source: Shire plc via GlobeNewswire
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