Bloomberg
(Bloomberg) -- Pfizer Inc. and BioNTech SE expect to deliver more vaccines to the European Union this quarter than currently targeted, offering good news to the bloc after deliveries of Johnson & Johnson’s shot were paused.Denmark became the first EU country to drop AstraZeneca Plc’s vaccine from its pandemic inoculation program, reflecting the same concerns over blood clots that prompted the J&J pause. Russia said there have been no cases of clotting with its Sputnik vaccine.South Africa said drugmakers including J&J demanded “unreasonable terms” in exchange for vaccine supplies. Germany’s rate of infections climbed further beyond a key threshold, and EU governments reached a deal on technical standards for so-called vaccine passports.Key Developments:Global Tracker: Cases pass 137 million; deaths exceed 2.96 millionVaccine Tracker: More than 814 million shots given worldwideVaccine givers at an Atlantic City convention hall race timeBlood Clots, anaphylaxis and other vaccine fears: QuickTakeWhat we know about the impact of Covid-19 on childrenWhich vaccine is best, and other questions answered (Video)Subscribe to a daily update on the virus from Bloomberg’s Prognosis team here. Click CVID on the terminal for global data on cases and deaths.Denver Ends Outdoor Mask Mandate (2 p.m. NY)Denver ended its outdoor mask mandate but will continue to require masks on public transit and indoor events, Mayor Michael Hancock announced Wednesday.Astra Shot Safe, Effective, Health Canada Says (11:40 a.m. NY)AstraZeneca’s vaccine may be linked to “very rare events of blood clots,” but the benefits of the shot outweigh its potential risk, Health Canada said in a statement following an assessment of scientific data.The federal agency has updated warnings about the possible side effects in product information and is providing information about potential symptoms as well as when to seek prompt medical attention following vaccination.J&J Drops Pregnant Women From Study (11:39 a.m. NY)Johnson & Johnson will revise protocols on its Covid-19 vaccine study and exclude pregnant health workers from a trial in South Africa set to include 500,000 people. The move came after U.S. regulators paused the shot’s rollout on concerns of a rare and severe blood-clotting side effect.While all studies are delayed, plans to run trials on children and pregnant women in South Africa have been set aside for now, said Glenda Gray, the co-lead of the South African studies, in an interview on Wednesday.The research team will meet with South African regulators later on Wednesday, she said.Airline Middle Seats Cited as Risk (11:38 a.m. NY)The risk of being exposed to the Covid-19 virus on an airline flight drop by as much as half when airlines keep middle seats open, a new study published by the U.S. government concludes, a safety practice the carriers have abandoned.The study is the latest to roil the waters on a controversial topic: just how risky it is to travel during the pandemic. It didn’t attempt to estimate infection risks and was based on modeling done before the pandemic, so it didn’t consider rules that now require face masks on flights.The risk of coming in contact with the virus dropped by 23% to 57% if airlines limited passenger loads on both single-aisle and widebody jets, compared with full occupancy, according to research released by the Centers for Disease Control and Prevention on Wednesday.U.S. Spy Chiefs Say Virus Source Unknown (11:25 a.m. NY)U.S. spy agencies have yet to determine the source of the virus that causes Covid-19, top intelligence officials told the Senate Intelligence Committee Wednesday.Avril Haines, the director of National Intelligence, said analysts are still examining two theories: animal-to-human transmission, and the possibility of a laboratory accident. “The intelligence community does not know exactly where, when or how Covid-19 virus was transmitted initially,” Haines said.CIA Director William Burns, echoed Haines’ assessment, adding that “the Chinese leadership has not been fully forthcoming or fully transparent” in working with the World Health Organization to pinpoint the origin of the coronavirus.The spy chiefs’ assessments add to a growing number of top politicians and public health experts who argue that the theory of a lab leak warrants further investigation. In late March, WHO Director-General Tedros Adhanom Ghebreyesus said a mission to study the origins of the virus was too quick to dismiss the theory of a lab leak.Russia Says No Clotting Cases From Sputnik (10:45 a.m. NY)The developers of Russia’s Sputnik V vaccine said it hasn’t produced any instances of the dangerous blood-clotting that forced U.S. officials to urge a pause in the use of Johnson & Johnson’s vaccine.Sputnik’s first dose uses the same human adenovirus as the Johnson & Johnson inoculation, but they have “significant differences in their structure” and it isn’t appropriate to extrapolate safety data from one to the other, the state-run Gamaleya Center said in a statement.Switzerland Allows Theaters to Open (10:45 a.m. NY)Switzerland will allow theaters, cinemas and outdoor dining at restaurants to open starting Monday, pursuing once again a more liberal course than many of its European neighbors.While facilities will be subject to capacity limitations, the move stands in contrast to France, where officials have responded to an increase in Covid-19 infections by doubling down on restrictions.Outdoor events will be limited to 100 people, while indoors at cinemas or concerts the maximum is 50.EU Sees J&J Recommendation Next Week (9:43 a.m. NY)The European Union’s drug regulator is accelerating its review of blood-clot reports with J&J’s vaccine and said it expects to issue a recommendation next week.EU member states should store doses as they await guidance, and the European Medicines Agency said it will decide shortly whether “regulatory action is necessary.”Astra Shot Induces Strong T-Cell Response (9:40 a.m. NY)The Astra vaccine generated a stronger cellular immune response than the Pfizer and BioNTech shot in people over 80 years old, a study by U.K. researchers shows.Responses in T cells -- a type of white blood cell that helps fight viruses -- were seen in 31% of participants receiving the Astra vaccine and 12% of the Pfizer-BioNTech group, according to the University of Birmingham and U.K. Coronavirus Immunology Consortium. Elderly people receiving a single dose of either vaccine showed equivalent antibody responses after five weeks.It’s unclear if the different levels of T cell responses observed will have any impact on clinical effectiveness, the researchers said.NYC Reschedules 4,000 Appointments (9:29 a.m. NY)New York City had to reschedule 4,000 shots on Tuesday due to the Johnson & Johnson pause, according to Health Commissioner Dave Chokshi. The “vast majority” of New Yorkers will keep the same appointments but receive the Pfizer or Moderna shots instead.The city’s homebound senior vaccine program, which depended on the J&J shot, will be suspended through Sunday, but the city is working to reschedule appointments and arrange transports by taxi or ambulette, Chokshi said.Denmark Is First in EU to Drop Astra Shot (8:14 a.m. NY)Denmark has become the first country in the European Union to drop AstraZeneca Plc’s vaccine from its inoculation program amid concerns over blood clots.Denmark was one of the first countries to suspend the vaccine, on March 11. At the time, the Danish Health Authority called the decision a precautionary move and reiterated its view that Astra’s vaccine was “effective and safe.”Pfizer to Speed EU Deliveries (7:42 a.m. NY)Pfizer Inc. and BioNTech SE will raise Covid-19 vaccine deliveries to the European Union by 50 million this quarter, offering good news to the bloc after Johnson & Johnson’s shot was paused.The drugmakers will bring forward deliveries scheduled for the fourth quarter, European Commission President Ursula von der Leyen said Wednesday. The additional supplies will add to the 200 million doses the EU was already expecting from Pfizer through June. The company provided about 66 million in the first three months of the year.EU Vaccine Passports Draw Closer (7:30 a.m. NY)European Union governments reached a deal on technical standards for so-called vaccine passports, advancing the effort to boost travel to and within the bloc in time for the summer season.Envoys meeting in Brussels unanimously supported a draft legal text setting out specifics for “digital green certificates,” according to a diplomat familiar with the private meeting. The documents will provide proof their holders have been vaccinated against the coronavirus, tested negative or have recently recovered from the disease and are considered immune.India to Get 250 Million Sputnik Doses (5:09 p.m. HK)Sputnik V’s capacity in India should be “ramped up significantly” in the next quarter, said Dr. Reddy’s Laboratories’s chief executive for API and Services Deepak Sapra.Initially, the vaccines will be imported from Russia and distributed by Dr. Reddy’s, according to Sapra. Eventually, six manufacturers in India are lined up to make the shot.Poland Extends Most Virus Restrictions (4:54 p.m. HK)Poland will reopen nurseries and kindergartens as of Monday but extend other restrictions that were due to end after April 18, Health Minister Adam Niedzielski said.S. Africa Says J&J Seeks Unreasonable Terms (4:13 p.m. HK)South Africa is facing delays to vaccine supplies because of “unreasonable terms” being demanded by manufacturers including Johnson & Johnson, Health Minister Zweli Mkhize said.J&J won’t sign off on 20 million doses until the company gets a letter from the trade and industry minister expressing support for its investment in local drugmaker Aspen, Mkhize told lawmakers.Denmark to Reopen Borders for Some Countries (2:26 p.m. HK)Denmark will gradually reopen its borders to some countries next month when older Danes are expected to have gotten at least one dose of vaccine, the government said.Denmark will be open to vaccinated citizens from European countries as of May 1. Residents who haven’t gotten a shot but come from European countries with low contamination rates will be able to enter Denmark from May 14. Travelers will need to provide a recent negative test and isolate upon arrival, unless they have been vaccinated.EasyJet Hangs on to Summer-Revival Hopes (2:22 p.m.)EasyJet Plc said it remains optimistic that European travel markets will be revived this summer even as vaccination campaigns and plans to reopen borders stutter.The London-based carrier will operate no more than 20% of 2019 capacity in the three months through June but said in a statement Wednesday that it’s ready to ramp up flights from May if there’s sufficient demand.Taiwan to Expand Covid Shots (2:12 p.m. HK)The government will provide 10,000 doses of vaccines for people who are traveling abroad from April 21, according to Taiwan’s Centers for Disease Control. Taiwan started to vaccinate healthcare workers from last month.German Incidence Rate Hits Three-Month High (1:37 p.m. HK)Germany’s infection rate climbed further beyond a key threshold, a day after the government approved legislation that mandates tougher restrictions in virus hotspots.The seven-day rate of cases per 100,000 people rose to 153.2, the most since Jan. 13, the RKI public-health agency said on its website.Chancellor Angela Merkel urged lawmakers in both houses of parliament to support the legislation, which triggers stricter curbs when the incidence rate climbs above 100.CanSino Finds No Severe Side Effects (1:29 p.m. HK)CanSino Biologics Inc said it hasn’t found any severe side effects such as blood clots after about 1 million vaccinations with its shot, which relies on the same approach as AstraZeneca Plc’s and Johnson & Johnson’s.The Astra, J&J and CanSino vaccines, as well as Russia’s Sputnik V, all uses an adenovirus to deliver the genetic material into the body to provoke a defense against Covid-19.France Prepares to Reopen Businesses (1:28 p.m. HK)President Emmanuel Macron will meet Thursday with ministers to prepare the rules for reopening French businesses next month.Macron said in March that bars and restaurants would be back in business in mid-May with outdoor seating, and that cultural establishments also would reopen.The country is eyeing a restart even as it prepares to cross the threshold of 100,000 deaths from Covid-19.For more articles like this, please visit us at bloomberg.comSubscribe now to stay ahead with the most trusted business news source.©2021 Bloomberg L.P.