Mikel Arteta will want to bounce back after seeing his side’s FA Cup defence fizzle out after an own-goal from Gabriel.
The teams played out a 1-1 draw at the Emirates in the reverse fixture earlier this season, which saw Theo Walcott score against his former club and Pierre-Emerick Aubameyang level for the hosts.
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Both teams will have ambitions on hunting down the teams above them to claim a European place this season as we enter the second half of the season.
Hasenhuttl is not getting carried away with his most recent victory and instead the Austrian wants more from his team: "It is a new game. I don't know how much impact it has on the game tomorrow, they will definitely want to turn the table around. So with a few changes in the team we have to show another good performance. With the ball we can play better than last Saturday, it was definitely not our best game with the ball. Without the ball it was a good game and against these top-six teams that is usually the most important thing."
Here’s everything you need to know about the game tonight:
When is it?
The fixture will kick-off at 20:15 GMT at St Mary’s.
How can I watch it?
The match is live on BT Sport 1 / BT Sport Ultimate, with coverage starting from 8pm GMT following the end of Newcastle vs Leeds. Subscribers can also stream the match via the BT Sport app or desktop website.
What is the team news?
Saints are likely to still be without Jannik Vestergaard (knee), Michael Obafemi (muscle), Moussa Djenepo (muscle), Mohammed Salisu (muscle) and Oriol Romeu (calf). Nathan Redmond could return, but Ryan Bertrand (suspension) and Kyle Walker-Peters (thigh) are also set to miss out.
Pierre-Emerick Aubameyang had a personal matter at the weekend, which ruled him out of the FA Cup tie, his involvement here is unclear still. Dani Ceballos (calf) is a doubt, Pablo Mari is still out, while Mikel Arteta is set to rotate his squad once more with a stronger line-up for this league meeting. Thomas Partey, Kieran Tierney, Emile Smith Rowe, Bukayo Saka and Alexandre Lacazette and Gabriel Martinelli are all in contention to start.
Southampton XI: McCarthy, Valery, Stephens, Bednarek, Vokins, Diallo, Ward-Prowse, Armstrong, Walcott, Ings, Adams
Arsenal XI: Leno, Bellerin, David Luiz, Holding, Cedric, Xhaka, Partey, Saka, Smith Rowe, Pepe, Lacazette
These two team are evenly matched and we can expect a good game tonight with both teams looking to play progressing, entertaining football. Saints have had the edge this season and we’ll lean towards them if somebody is to emerge victorious, but Mikel Arteta’s side should respond after last weekend’s FA Cup exit and take a valuable point back to the capital. 1-1.