Green, 50, and Barrymore, 46, shared a sweet moment as they recalled their time together, with the comedian telling the actress, "I kinda feel like I'm watching this too right now. It's sort of like an out-of-body experience."
"I respect and love you," Barrymore told Green, who appeared moved as he replied, "Thank you, Drew. Love you."
Green rose to fame in the '90s with his MTV show The Tom Green Show, which ran from 1994 to 2000. After that, he went on to star in movies Roadtrip, Charlie's Angels, which Barrymore also starred in, and Freddy Got Fingered and Stealing Harvard.
The comedian has steadily continued working over the years in movies like Stick It, Total Frat Movie, Bethany, Iron Sky: The Coming Race, Uploaded, and the upcoming short film Bug Therapy, as well as Back Home Again, which he executive produced.
Green started his own podcast, The Tom Green Podcast, last year. The actor's home base is his native Canada, which he frequently shares photos of on Instagram, along with his dog Charley.
In July, Green announced on his Instagram account that he was moving to Canada after 20 years in Los Angeles and one year of living in his van.
"The Big News! - I Am Coming Home To Canada," he wrote in the caption. "I am so excited to tell you my big news. I am coming home to Canada and moving to the wilderness.🍁 This last year living the van life has reminded me how much I appreciate having a daily connection with nature."
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"Looking forward to showing you my new home very soon. We will have lots to explore and discover," he continued. "I can't wait to bring you along on this new adventure and next chapter in my life. This is gonna be fun! Stay tuned more posts coming very soon!"
In the video, Green grew emotional as he told fans, "Next time you see me, I'm going to be home."