The Portuguese is taking charge of his first north London derby with Spurs without a win in their last two Premier League outings.
Lucas Moura returns not only to the matchday squad but is straight into the starting XI after injury.
Lucas was substituted during last week’s Europa Conference League match at Rennes and then subsequently missed last Sunday’s 3-0 home defeat against Chelsea. The Brazilian comes into the side for Giovani Lo Celso.
Japhet Tanganga returns from suspension at right-back in place of Emerson Royal.
The final of the three changes sees Davinson Sanchez replace another summer signing in Cristian Romero.
Tottenham are still without Steven Bergwijn due to injury. Ryan Sessegnon is also sidelined.
Tottenham XI (4-3-3): Lloris; Tanganga, Sanchez, Dier, Reguilon; Dele, Hojbjerg, Ndombele; Lucas, Kane, Son
Subs: Romero, Gil, Emerson, Rodon, Lo Celso, Gollini, Skipp, Davies, Scarlett