Insider	Transaction	Type	Value	Date	Shares
LOUMEAU ERIC JOSEPH Chief Operating Officer	Sale at price 24.00 per share.	Direct	60,000	08 Jun 2022	2,500
LOUMEAU ERIC JOSEPH Chief Operating Officer	Conversion of Exercise of derivative security at price 14.02 per share.	Direct	35,050	08 Jun 2022	2,500
LOUMEAU ERIC JOSEPH Chief Operating Officer	Sale at price 20.50 per share.	Direct	23,493	18 May 2022	1,146
ECOR1 CAPITAL, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Purchase at price 21.63 per share.	Indirect	14,453,966	05 May 2022	668,237
ECOR1 CAPITAL, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Sale at price 21.63 per share.	Indirect	14,453,966	05 May 2022	668,237
FAGA DANIEL R Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	21 Mar 2022	887,043
SURIA HAMZA Chief Executive Officer	Sale at price 34.89 - 36.40 per share.	Direct	1,303,559	20 Dec 2021	36,645
SURIA HAMZA Chief Executive Officer	Conversion of Exercise of derivative security at price 1.12 per share.	Direct	41,042	20 Dec 2021	36,645
MULROY DENNIS M Chief Financial Officer	Stock Award(Grant) at price 32.15 per share.	Direct	30,993	15 Nov 2021	964
SURIA HAMZA Chief Executive Officer	Stock Award(Grant) at price 32.15 per share.	Direct	30,993	15 Nov 2021	964
LIZZUL PAUL F. M.D. PH.D. Officer	Stock Award(Grant) at price 32.15 per share.	Direct	30,993	15 Nov 2021	964
LOUMEAU ERIC JOSEPH Chief Operating Officer	Stock Award(Grant) at price 32.15 per share.	Direct	16,814	15 Nov 2021	523
SURIA HAMZA Chief Executive Officer	Sale at price 35.00 per share.	Direct	712,635	05 Nov 2021	20,361
SURIA HAMZA Chief Executive Officer	Conversion of Exercise of derivative security at price 1.12 per share.	Direct	22,804	05 Nov 2021	20,361
LOUMEAU ERIC JOSEPH Chief Operating Officer	Sale at price 35.00 per share.	Direct	175,000	04 Nov 2021	5,000
LOUMEAU ERIC JOSEPH Chief Operating Officer	Conversion of Exercise of derivative security at price 14.02 - 20.16 per share.	Direct	85,450	04 Nov 2021	5,000
SURIA HAMZA Chief Executive Officer	Sale at price 32.27 - 32.88 per share.	Direct	1,184,106	01 Nov 2021	36,646
SURIA HAMZA Chief Executive Officer	Conversion of Exercise of derivative security at price 1.12 per share.	Direct	41,044	01 Nov 2021	36,646
SURIA HAMZA Chief Executive Officer	Sale at price 30.00 per share.	Direct	479,790	26 Oct 2021	15,993
SURIA HAMZA Chief Executive Officer	Conversion of Exercise of derivative security at price 1.12 per share.	Direct	17,912	26 Oct 2021	15,993
SURIA HAMZA Chief Executive Officer	Conversion of Exercise of derivative security at price 1.12 per share.	Direct	11,200	17 Sept 2021	10,000
SURIA HAMZA Chief Executive Officer	Conversion of Exercise of derivative security at price 1.12 per share.	Direct	11,200	12 May 2021	10,000
ECOR1 CAPITAL, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Purchase at price 23.16 - 23.31 per share.	Indirect	5,147,444	04 May 2021	221,500
ECOR1 CAPITAL, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Purchase at price 23.54 - 23.82 per share.	Indirect	3,480,233	27 Apr 2021	147,300
ECOR1 CAPITAL, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Purchase at price 18.70 - 18.97 per share.	Indirect	62,622,736	09 Mar 2021	3,308,800
ECOR1 CAPITAL, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Purchase at price 25.48 per share.	Indirect	751,657	23 Feb 2021	29,500
LOUMEAU ERIC JOSEPH Chief Operating Officer	Sale at price 35.00 per share.	Direct	350,000	12 Feb 2021	10,000
LOUMEAU ERIC JOSEPH Chief Operating Officer	Conversion of Exercise of derivative security at price 14.02 per share.	Direct	140,200	12 Feb 2021	10,000
SURIA HAMZA Chief Executive Officer	Conversion of Exercise of derivative security at price 1.12 per share.	Direct	11,200	10 Mar 2020	10,000
SURIA HAMZA Chief Executive Officer	Conversion of Exercise of derivative security at price 1.12 per share.	Direct	11,200	05 Feb 2020	10,000
WARE J ANTHONY Director	Purchase at price 14.05 per share.	Direct	50,580	10 Dec 2019	3,600
LONDEI MARCO M.D. Officer	Conversion of Exercise of derivative security at price 6.93 per share.	Direct	320,180	27 Nov 2019	46,202
SURIA HAMZA Chief Executive Officer	Conversion of Exercise of derivative security at price 1.12 per share.	Direct	11,200	22 Nov 2019	10,000
SURIA HAMZA Chief Executive Officer	Sale at price 72.64 - 76.31 per share.	Direct	1,654,350	10 Jun 2019	22,428
LONDEI MARCO M.D. Officer	Sale at price 72.45 - 74.50 per share.	Direct	734,962	04 Jun 2019	10,060
LONDEI MARCO M.D. Officer	Conversion of Exercise of derivative security at price 0.70 per share.	Direct	7,042	04 Jun 2019	10,060
SURIA HAMZA Chief Executive Officer	Conversion of Exercise of derivative security at price 1.12 per share.	Direct	11,200	17 Apr 2019	10,000
LONDEI MARCO M.D. Officer	Sale at price 69.29 - 70.04 per share.	Direct	1,332,882	15 Jan 2019	19,075
LONDEI MARCO M.D. Officer	Conversion of Exercise of derivative security at price 6.93 per share.	Direct	132,190	15 Jan 2019	19,075
SURIA HAMZA Chief Executive Officer	Sale at price 70.65 - 71.10 per share.	Direct	2,831,532	14 Jan 2019	40,000
SURIA HAMZA Chief Executive Officer	Conversion of Exercise of derivative security at price 1.12 per share.	Direct	44,800	14 Jan 2019	40,000
LONDEI MARCO M.D. Officer	Stock Gift at price 0.00 per share.	Direct	0	26 Dec 2018	122,500
LONDEI MARCO M.D. Officer	Sale at price 65.36 - 68.47 per share.	Direct	2,005,856	17 Dec 2018	30,048
LONDEI MARCO M.D. Officer	Conversion of Exercise of derivative security at price 0.70 - 6.93 per share.	Direct	158,094	17 Dec 2018	30,048
SURIA HAMZA Chief Executive Officer	Sale at price 68.89 - 70.51 per share.	Direct	2,894,375	14 Dec 2018	41,728
SURIA HAMZA Chief Executive Officer	Conversion of Exercise of derivative security at price 1.12 per share.	Direct	46,735	14 Dec 2018	41,728
SURIA HAMZA Chief Executive Officer	Sale at price 70.57 - 72.88 per share.	Direct	4,687,413	12 Dec 2018	65,585
SURIA HAMZA Chief Executive Officer	Conversion of Exercise of derivative security at price 1.12 per share.	Direct	67,857	12 Dec 2018	60,587
PISCITELLI DOMINIC G. Chief Financial Officer	Sale at price 70.34 - 75.81 per share.	Direct	2,669,158	03 Dec 2018	37,000
PISCITELLI DOMINIC G. Chief Financial Officer	Conversion of Exercise of derivative security at price 11.34 per share.	Direct	419,580	03 Dec 2018	37,000
LONDEI MARCO M.D. Officer	Conversion of Exercise of derivative security at price 0.70 per share.	Direct	100,000	07 Sept 2018	142,857
SURIA HAMZA Chief Executive Officer	Conversion of Exercise of derivative security at price 1.61 - 2.24 per share.	Direct	13,194	09 Jul 2018	7,636
SURIA HAMZA Chief Executive Officer	Conversion of Exercise of derivative security at price 2.59 per share.	Direct	58,089	08 Jun 2018	22,428
LYDON NICHOLAS B. Director	Sale at price 84.18 - 90.26 per share.	Direct	2,866,913	16 Apr 2018	33,000
LYDON NICHOLAS B. Director	Conversion of Exercise of derivative security at price 4.55 per share.	Direct	74,998	15 Feb 2018	16,483
NOVO HOLDINGS A/S Beneficial Owner of more than 10% of a Class of Security	Sale at price 21.10 per share.	Direct	7,518,251	21 Aug 2017	356,300
NOVO HOLDINGS A/S Beneficial Owner of more than 10% of a Class of Security	Sale at price 21.00 - 21.79 per share.	Direct	3,778,481	15 Aug 2017	178,600
NOVO HOLDINGS A/S Beneficial Owner of more than 10% of a Class of Security	Sale at price 21.10 - 22.92 per share.	Direct	10,377,406	07 Aug 2017	491,294
NOVO HOLDINGS A/S Beneficial Owner of more than 10% of a Class of Security	Sale at price 22.01 - 23.87 per share.	Direct	1,647,947	03 Aug 2017	70,706
AVALON VENTURES VII L P Beneficial Owner of more than 10% of a Class of Security	Sale at price 24.35 per share.	Indirect	901,924	26 Jul 2017	37,040
FRAZIER HEALTHCARE VII L.P., Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 4.55 per share.	Indirect	533,419	02 Feb 2017	117,235
GALLAGHER CAROL GILTNER Director		Direct		31 Jan 2017	64,296
TOPPER JAMES N Director and Beneficial Owner of more than 10% of a Class of Security	Purchase at price 15.00 per share.	Indirect	6,000,000	31 Jan 2017	400,000
TOPPER JAMES N Director and Beneficial Owner of more than 10% of a Class of Security		Indirect		31 Jan 2017	3,171,212
NOVO HOLDINGS A/S Beneficial Owner of more than 10% of a Class of Security	Purchase at price 15.00 per share.	Direct	750,000	31 Jan 2017	50,000
NOVO HOLDINGS A/S Beneficial Owner of more than 10% of a Class of Security		Direct		31 Jan 2017	2,983,504
LYDON NICHOLAS B. Director	Purchase at price 15.00 per share.	Direct	249,990	31 Jan 2017	16,666
LYDON NICHOLAS B. Director		Direct		31 Jan 2017	203,625
LONDEI MARCO M.D. Officer		Direct		31 Jan 2017	2,020
SURIA HAMZA Chief Executive Officer		Direct		31 Jan 2017	4,998
FRAZIER HEALTHCARE VII L.P., Beneficial Owner of more than 10% of a Class of Security	Purchase at price 15.00 per share.	Indirect	6,000,000	31 Jan 2017	400,000
FRAZIER HEALTHCARE VII L.P., Beneficial Owner of more than 10% of a Class of Security		Indirect		31 Jan 2017	3,171,212

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Insider transactions

Insider transactions reported - last two years

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