Insider	Transaction	Type	Value	Date	Shares
SIMPSON JENNIFER K Director		Direct		15 Dec 2021	25,000
BRIEN EARL W. M.D. Director	Conversion of Exercise of derivative security at price 0.26 per share.	Direct	39,000	14 Aug 2020	150,000
KRIEGSMAN STEVEN A Chief Executive Officer	Conversion of Exercise of derivative security at price 0.26 per share.	Direct	780,000	07 Aug 2020	3,000,000
IGNARRO LOUIS J Director	Conversion of Exercise of derivative security at price 0.26 per share.	Direct	182,000	07 Aug 2020	700,000
CALDWELL JOEL K Director	Conversion of Exercise of derivative security at price 0.26 per share.	Direct	117,000	07 Aug 2020	450,000
KRIEGSMAN STEVEN A Chief Executive Officer	Stock Award(Grant) at price 1.75 per share.	Direct	678,295	15 Dec 2017	387,597
KRIEGSMAN STEVEN A Chief Executive Officer	Stock Award(Grant) at price 0.43 per share.	Direct	1,000,000	15 Dec 2016	2,325,581
LEVITT DANIEL J Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	01 Jan 2014	100,000
LEVITT DANIEL J Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	01 Jan 2014	100,000
LEVITT DANIEL J Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	01 Jan 2014	100,000
PATTERSON SCOTT BRADFORD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 2.35 - 2.48 per share.	Direct	694,519	03 Dec 2013	284,979
PATTERSON SCOTT BRADFORD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 2.06 per share.	Direct	102,840	07 Nov 2013	50,000
PATTERSON SCOTT BRADFORD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 2.70 per share.	Direct	11,024	01 Apr 2013	4,083
PATTERSON SCOTT BRADFORD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 2.56 - 2.58 per share.	Direct	91,476	20 Mar 2013	35,520
PATTERSON SCOTT BRADFORD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 2.61 per share.	Direct	10,388	20 Mar 2013	3,980
PATTERSON SCOTT BRADFORD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 2.52 - 2.67 per share.	Direct	147,647	13 Mar 2013	55,360
LEVITT DANIEL J Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	31 Dec 2012	100,000
LEVITT DANIEL J Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	31 Dec 2012	100,000
PATTERSON SCOTT BRADFORD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 2.51 per share.	Direct	451,666	22 Oct 2012	180,000
PATTERSON SCOTT BRADFORD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 2.50 per share.	Direct	3,000,000	18 Oct 2012	1,200,000
PATTERSON SCOTT BRADFORD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 4.90 - 5.32 per share.	Direct	230,344	28 Jun 2012	44,824
PATTERSON SCOTT BRADFORD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 4.61 - 5.16 per share.	Direct	137,173	25 Jun 2012	27,462
PATTERSON SCOTT BRADFORD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 4.25 - 4.65 per share.	Direct	94,730	20 Jun 2012	21,114
PATTERSON SCOTT BRADFORD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 3.83 - 3.89 per share.	Direct	55,914	15 Jun 2012	14,534
PATTERSON SCOTT BRADFORD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 3.80 - 3.88 per share.	Direct	76,293	13 Jun 2012	19,770
PATTERSON SCOTT BRADFORD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 3.80 per share.	Direct	168,581	11 Jun 2012	44,332
PATTERSON SCOTT BRADFORD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 3.85 - 3.97 per share.	Direct	561,888	07 Jun 2012	145,233
PATTERSON SCOTT BRADFORD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 3.53 - 3.83 per share.	Direct	1,831,967	04 Jun 2012	497,896
LINK MAX E Director	Purchase at price 0.31 - 0.33 per share.	Direct	65,857	23 Feb 2012	205,329
WENNEKAMP RICHARD L Director	Purchase at price 0.31 - 0.33 per share.	Direct	35,911	23 Feb 2012	111,965
KRIEGSMAN STEVEN A Chief Executive Officer	Purchase at price 0.31 - 0.33 per share.	Direct	50,893	23 Feb 2012	158,676
CALOZ JOHN Y Chief Financial Officer	Purchase at price 0.31 - 0.33 per share.	Direct	10,197	23 Feb 2012	31,792
LEVIN BENJAMIN S General Counsel	Purchase at price 0.31 - 0.33 per share.	Direct	10,770	23 Feb 2012	33,578
LEVITT DANIEL J Officer	Purchase at price 0.29 per share.	Direct	28,750	22 Feb 2012	100,000
SELTER MARVIN R Director	Purchase at price 0.31 per share.	Direct	31,200	22 Feb 2012	100,000
TEPPER MARK A Officer	Sale at price 4.30 - 4.31 per share.	Direct	322,506	09 May 2007	75,000
TEPPER MARK A Officer	Conversion of Exercise of derivative security at price 2.41 per share.	Direct	180,750	09 May 2007	75,000
TEPPER MARK A Officer	Sale at price 4.15 - 4.21 per share.	Direct	313,762	02 May 2007	75,000
TEPPER MARK A Officer	Conversion of Exercise of derivative security at price 2.41 per share.	Direct	180,750	02 May 2007	75,000
LINK MAX E Director	Conversion of Exercise of derivative security at price 0.71 - 1.00 per share.	Direct	22,106	27 Apr 2007	25,769
TEPPER MARK A Officer	Sale at price 4.11 per share.	Direct	308,250	27 Apr 2007	75,000
TEPPER MARK A Officer	Conversion of Exercise of derivative security at price 2.41 per share.	Direct	180,750	27 Apr 2007	75,000
KRIEGSMAN STEVEN A Chief Executive Officer	Conversion of Exercise of derivative security at price 0.01 per share.	Direct	4,594	28 Nov 2005	459,352
WENNEKAMP RICHARD L Director	Purchase at price 1.07 per share.	Direct	5,350	30 Aug 2004	5,000
MCDADE HERBERT H JR Director	Sale at price 2.25 - 2.34 per share.	Direct	88,247	17 Jun 2003	38,551
MCDADE HERBERT H JR Director	Conversion of Exercise of derivative security at price 0.93 - 1.03 per share.	Direct	36,311	16 Jun 2003	36,861
CARNAHAN RAYMOND C JR Director	Sale at price 2.40 - 2.49 per share.	Indirect	70,880	05 Jun 2003	29,372
CARNAHAN RAYMOND C JR Director	Conversion of Exercise of derivative security at price 0.93 - 1.03 per share.	Direct	28,828	05 Jun 2003	29,372
CARNAHAN RAYMOND C JR Director	Sale at price 2.26 per share.	Indirect	1,831	03 Jun 2003	810
MCDADE HERBERT H JR Director	Conversion of Exercise of derivative security at price 10.00 per share.	Direct	6,900	16 May 2003	690
CARNAHAN RAYMOND C JR Director	Conversion of Exercise of derivative security at price 1.00 per share.	Direct	560	14 May 2003	560
LUCHESE JACK J Former	Sale at price 0.24 - 0.96 per share.	Direct	64,621	08 Apr 2003	129,332
IGNARRO LOUIS J Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	19 Jul 2002	91,916
CAPPELLO ALEXANDER L Director	Stock Award(Grant) at price 0.00 per share.	Indirect	0	16 Jul 2002	153,262
CAPPELLO ALEXANDER L Director	Stock Award(Grant) at price 0.00 per share.	Indirect	0	16 Jul 2002	153,262
EMANUELE ROBERT MARTIN Former	Stock Award(Grant) at price 0.58 per share.	Direct	39,808	16 Jul 2002	68,634
FLECK WILLIAM B Former	Stock Award(Grant) at price 0.58 per share.	Direct	24,880	16 Jul 2002	42,896
GRINDEL J MICHAEL Former	Stock Award(Grant) at price 0.58 per share.	Direct	44,784	16 Jul 2002	77,213
REYNOLDS MARK W Former	Stock Award(Grant) at price 0.58 per share.	Direct	34,832	16 Jul 2002	60,055
LUCHESE JACK J Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	11 Feb 2002	558,060
FLECK WILLIAM B Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	04 Jan 2002	4,085
LUCHESE JACK J Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	04 Jan 2002	52,438
REYNOLDS MARK W Chief Financial Officer	Purchase at price 0.85 - 0.88 per share.	Direct	1,745	30 May 2001	2,000
REYNOLDS MARK W Chief Financial Officer	Purchase at price 1.00 per share.	Direct	2,000	09 Feb 2001	2,000
REYNOLDS MARK W Chief Financial Officer	Purchase at price 0.81 per share.	Direct	1,625	11 Jan 2001	2,000
EMANUELE ROBERT MARTIN Officer	Stock Award(Grant) at price 0.00 per share.	Indirect	0	31 Jan 2000	2,440
FLECK WILLIAM B Officer	Stock Award(Grant) at price 0.00 per share.	Indirect	0	31 Jan 2000	6,013
LUCHESE JACK J Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Indirect	0	31 Jan 2000	3,024
GRINDEL J MICHAEL Officer	Stock Award(Grant) at price 0.00 per share.	Indirect	0	31 Jan 2000	3,496
REYNOLDS MARK W Officer	Stock Award(Grant) at price 0.00 per share.	Indirect	0	31 Jan 2000	2,774
LINK MAX E Director	Conversion of Exercise of derivative security at price 1.00 per share.	Direct	7,541	08 Feb 1999	7,541
EMANUELE ROBERT MARTIN Officer	Stock Award(Grant) at price 0.97 per share.	Indirect	1,569	31 Dec 1998	1,618
FLECK WILLIAM B Officer	Stock Award(Grant) at price 0.00 per share.	Indirect	0	31 Dec 1998	5,211
REYNOLDS MARK W Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Indirect	0	30 Dec 1998	830
REYNOLDS MARK W Chief Financial Officer	Purchase at price 0.94 per share.	Direct	1,880	30 Dec 1998	2,000
GRINDEL J MICHAEL Officer	Stock Award(Grant) at price 0.00 per share.	Indirect	0	09 Dec 1998	641
GRINDEL J MICHAEL Officer	Purchase at price 1.00 per share.	Direct	500	09 Dec 1998	500
GRINDEL J MICHAEL Officer	Purchase at price 1.09 per share.	Direct	545	20 Nov 1998	500
GRINDEL J MICHAEL Officer	Purchase at price 0.78 per share.	Direct	390	14 Oct 1998	500
REYNOLDS MARK W Chief Financial Officer	Purchase at price 0.88 per share.	Direct	1,760	13 Oct 1998	2,000
GRINDEL J MICHAEL Officer	Purchase at price 1.06 per share.	Direct	530	14 Sept 1998	500
REYNOLDS MARK W Chief Financial Officer	Purchase at price 1.25 per share.	Direct	1,250	28 Aug 1998	1,000
GRINDEL J MICHAEL Officer	Purchase at price 1.81 per share.	Direct	905	12 Aug 1998	500
GRINDEL J MICHAEL Officer	Purchase at price 2.06 per share.	Direct	1,030	13 Jul 1998	500
MCDADE HERBERT H JR Director	Stock Award(Grant) at price 1.00 per share.	Direct	25,000	30 Jun 1998	25,000
BEAUCHARD LUCINE E Vice President	Stock Award(Grant) at price 6.38 per share.	Direct	957,000	30 Jun 1998	150,000
CARNAHAN RAYMOND C JR Director	Stock Award(Grant) at price 1.25 per share.	Direct	18,750	30 Jun 1998	15,000
DAVIS JOSEPH MORTON Beneficial Owner of more than 10% of a Class of Security	Stock Award(Grant) at price 7.20 per share.	Indirect	2,084,400	30 Jun 1998	289,500
SELVI VESCOVI Director	Stock Award(Grant) at price 6.38 per share.	Direct	63,800	30 Jun 1998	10,000
HEMINGWAY SAMUEL SCOTT Director	Stock Award(Grant) at price 1.85 per share.	Direct	97,264	30 Jun 1998	52,575
LUCHESE JACK J Chief Executive Officer	Purchase at price 2.13 per share.	Direct	2,130	29 Jun 1998	1,000
GRINDEL J MICHAEL Officer	Stock Award(Grant) at price 0.00 per share.	Indirect	0	29 May 1998	789
GRINDEL J MICHAEL Officer	Purchase at price 2.69 per share.	Direct	2,690	29 May 1998	1,000
LUCHESE JACK J Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Indirect	0	19 May 1998	1,671
LUCHESE JACK J Chief Executive Officer	Purchase at price 2.50 per share.	Direct	1,250	19 May 1998	500
REYNOLDS MARK W Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Indirect	0	18 May 1998	633
REYNOLDS MARK W Chief Financial Officer	Purchase at price 2.75 per share.	Direct	2,750	18 May 1998	1,000
EMANUELE ROBERT MARTIN Officer	Stock Award(Grant) at price 0.00 per share.	Indirect	0	30 Jan 1998	712
FLECK WILLIAM B Officer	Stock Award(Grant) at price 0.00 per share.	Indirect	0	30 Jan 1998	3,464
LUCHESE JACK J Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Indirect	0	30 Jan 1998	7,678
REYNOLDS MARK W Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Indirect	0	30 Jan 1998	328
REYNOLDS MARK W Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Indirect	0	29 Oct 1997	951
REYNOLDS MARK W Chief Financial Officer	Purchase at price 4.06 per share.	Direct	6,090	29 Oct 1997	1,500
EMANUELE ROBERT MARTIN Officer	Stock Award(Grant) at price 0.00 per share.	Indirect	0	04 Aug 1997	304
EMANUELE ROBERT MARTIN Officer	Purchase at price 3.25 - 3.31 per share.	Direct	6,612	04 Aug 1997	2,000
LINK MAX E Chief Executive Officer	Purchase at price 3.94 per share.	Direct	39,400	16 Apr 1997	10,000
FLECK WILLIAM B Vice President	Stock Award(Grant) at price 0.00 per share.	Indirect	0	31 Jan 1997	3,134
LUCHESE JACK J Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Indirect	0	31 Jan 1997	8,551
REYNOLDS MARK W Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Indirect	0	31 Jan 1997	1,106
LUCHESE JACK J Chief Executive Officer	Purchase at price 3.38 per share.	Direct	10,140	03 Jan 1997	3,000
EMANUELE ROBERT MARTIN Vice President	Purchase at price 3.63 per share.	Direct	10,890	30 Dec 1996	3,000
EMANUELE ROBERT MARTIN Vice President	Stock Award(Grant) at price 0.00 per share.	Indirect	0	20 Dec 1996	1,100
YAHRES JAMES M Vice President	Purchase at price 3.94 per share.	Direct	11,820	11 Nov 1996	3,000
MCDADE HERBERT H JR Director	Purchase at price 4.00 per share.	Direct	4,000	23 Sept 1996	1,000
EMANUELE ROBERT MARTIN Vice President	Purchase at price 4.13 per share.	Direct	12,390	05 Aug 1996	3,000
YAHRES JAMES M Vice President	Purchase at price 4.00 - 4.06 per share.	Direct	12,120	24 Jul 1996	3,000
BEAUCHARD LUCINE E Shareholder	Stock Award(Grant) at price 0.00 per share.	Indirect	0	01 Apr 1996	609
YAHRES JAMES M Vice President	Stock Award(Grant) at price 0.00 per share.	Indirect	0	01 Apr 1996	645
LUCHESE JACK J President	Stock Award(Grant) at price 3.69 per share.	Direct	738,000	27 Mar 1996	200,000
LUCHESE JACK J Chief Executive Officer	Purchase at price 4.44 - 4.50 per share.	Direct	17,532	05 Mar 1996	3,900
LUCHESE JACK J Chief Executive Officer	Purchase at price 4.44 per share.	Direct	17,760	29 Feb 1996	4,000
LUCHESE JACK J President	Purchase at price 0.97 per share.	Indirect	8,148	15 Dec 1995	8,400
YAHRES JAMES M Vice President	Stock Award(Grant) at price 0.00 - 1.00 per share.	Indirect	15,000	08 Dec 1995	17,595
EMANUELE ROBERT MARTIN Officer	Sale at price 1.00 per share.	Indirect	4,000	25 Oct 1995	4,000
EMANUELE ROBERT MARTIN Vice President	Stock Award(Grant) at price 0.00 per share.	Indirect	0	29 Sept 1995	788
FLECK WILLIAM B Vice President	Stock Award(Grant) at price 0.00 per share.	Indirect	0	29 Sept 1995	2,509
REYNOLDS MARK W Officer	Stock Award(Grant) at price 0.00 per share.	Indirect	0	29 Sept 1995	2,166
BEAUCHARD LUCINE E Vice President	Stock Award(Grant) at price 0.00 per share.	Indirect	0	30 Jun 1995	2,594
CASIERI FRANCIS J Vice President	Stock Award(Grant) at price 0.00 per share.	Indirect	0	30 Jun 1995	2,595
EMANUELE ROBERT MARTIN Officer	Stock Award(Grant) at price 0.00 per share.	Indirect	0	30 Jun 1995	1,416
CARNAHAN RAYMOND C JR Director	Purchase at price 2.31 per share.	Indirect	2,310	22 Jun 1995	1,000
MCDADE HERBERT H JR Director	Stock Award(Grant) at price 2.19 per share.	Direct	16,425	08 Jun 1995	7,500
CARNAHAN RAYMOND C JR Director	Stock Award(Grant) at price 2.19 per share.	Direct	16,425	08 Jun 1995	7,500
BOWMAN JACK L Director	Stock Award(Grant) at price 2.19 per share.	Direct	16,425	08 Jun 1995	7,500
SELVI VESCOVI Director	Stock Award(Grant) at price 2.19 per share.	Direct	16,425	08 Jun 1995	7,500
YAHRES JAMES M Vice President	Purchase at price 1.69 per share.	Indirect	1,690	01 Jun 1995	1,000
YAHRES JAMES M Vice President	Purchase at price 1.50 - 1.56 per share.	Indirect	1,548	30 May 1995	1,000
LUCHESE JACK J President	Stock Award(Grant) at price 0.00 per share.	Indirect	0	31 Mar 1995	2,627
LUCHESE JACK J President	Purchase at price 2.25 per share.	Indirect	11,250	19 Oct 1994	5,000
YAHRES JAMES M Officer	Stock Award(Grant) at price 0.00 per share.	Indirect	0	27 Sept 1994	434
YAHRES JAMES M Officer	Purchase at price 2.50 per share.	Indirect	2,500	27 Sept 1994	1,000
BEAUCHARD LUCINE E Divisional Officer	Purchase at price 3.88 per share.	Indirect	11,640	22 Jul 1994	3,000
BEAUCHARD LUCINE E Divisional Officer	Purchase at price 5.13 per share.	Indirect	5,130	13 Jun 1994	1,000
CARNAHAN RAYMOND C JR Director	Sale at price 5.63 per share.	Indirect	28,150	01 Jun 1994	5,000
CARNAHAN RAYMOND C JR Director	Conversion of Exercise of derivative security at price 1.25 per share.	Direct	12,500	24 May 1994	10,000
BOWMAN JACK L Director	Stock Award(Grant) at price 5.63 per share.	Direct	112,600	19 May 1994	20,000
LUCHESE JACK J President	Stock Award(Grant) at price 0.00 per share.	Indirect	0	31 Mar 1994	737
CASIERI FRANCIS J Divisional Officer	Stock Award(Grant) at price 6.13 per share.	Direct	306,500	29 Mar 1994	50,000
FLECK WILLIAM B Divisional Officer	Stock Award(Grant) at price 3.75 per share.	Direct	187,500	19 Apr 1993	50,000
BEAUCHARD LUCINE E Divisional Officer	Purchase at price 3.88 per share.	Indirect	7,760	16 Apr 1993	2,000

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Insider transactions

Insider transactions reported - last two years

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