Insider	Transaction	Type	Value	Date	Shares
MECKLAI HUSSEIN Chief Operating Officer	Sale at price 154.17 - 154.98 per share.	Direct	771,882	01 May 2024	5,000
MECKLAI HUSSEIN Chief Operating Officer	Conversion of Exercise of derivative security at price 17.75 per share.	Direct	88,750	01 May 2024	5,000
PADVAL UMESH VISHNU Director	Sale at price 149.14 - 154.01 per share.	Direct	526,074	26 Apr 2024	3,475
PHELAN CATHAL G Officer and Director	Sale at price 146.34 - 153.81 per share.	Direct	1,479,359	26 Apr 2024	10,000
DOSSETT JEFFREY JOHN Officer	Sale at price 144.73 - 148.44 per share.	Direct	1,166,128	26 Apr 2024	8,000
DOSSETT JEFFREY JOHN Officer	Conversion of Exercise of derivative security at price 17.33 per share.	Direct	138,640	26 Apr 2024	8,000
DIORIO CHRIS PH.D Chief Executive Officer	Stock Gift at price 0.00 per share.	Direct	0	26 Apr 2024	20,000
DIORIO CHRIS PH.D Chief Executive Officer	Sale at price 145.12 - 153.83 per share.	Direct	3,919,790	26 Apr 2024	26,661
DIORIO CHRIS PH.D Chief Executive Officer	Conversion of Exercise of derivative security at price 21.81 per share.	Direct	581,476	26 Apr 2024	26,661
DOSSETT JEFFREY JOHN Officer	Sale at price 118.24 - 119.00 per share.	Direct	59,111	15 Apr 2024	498
DIORIO CHRIS PH.D Chief Executive Officer	Sale at price 118.47 - 119.10 per share.	Direct	147,626	15 Apr 2024	1,244
BAKER CARY L. Chief Financial Officer	Sale at price 118.60 - 119.24 per share.	Direct	44,393	15 Apr 2024	374
MECKLAI HUSSEIN Chief Operating Officer	Sale at price 118.28 - 119.03 per share.	Direct	51,656	15 Apr 2024	435
DOSSETT JEFFREY JOHN Officer		Direct		12 Apr 2024	1,250
DIORIO CHRIS PH.D Chief Executive Officer		Direct		12 Apr 2024	3,125
BAKER CARY L. Chief Financial Officer		Direct		12 Apr 2024	938
MECKLAI HUSSEIN Chief Operating Officer		Direct		12 Apr 2024	1,094
WASHINGTON MIRON L Director		Direct		02 Apr 2024	342
PHELAN CATHAL G Officer and Director	Sale at price 126.83 per share.	Direct	106,668	25 Mar 2024	841
DOSSETT JEFFREY JOHN Officer	Sale at price 126.95 - 127.94 per share.	Direct	153,361	25 Mar 2024	1,208
DIORIO CHRIS PH.D Chief Executive Officer	Sale at price 127.02 - 127.88 per share.	Direct	375,595	25 Mar 2024	2,953
BAKER CARY L. Chief Financial Officer	Sale at price 126.86 - 128.13 per share.	Direct	135,524	25 Mar 2024	1,062
MECKLAI HUSSEIN Chief Operating Officer	Sale at price 126.83 per share.	Direct	184,667	25 Mar 2024	1,456
PHELAN CATHAL G Officer and Director		Direct		22 Mar 2024	1,652
DOSSETT JEFFREY JOHN Officer		Direct		22 Mar 2024	3,053
DIORIO CHRIS PH.D Chief Executive Officer		Direct		22 Mar 2024	7,489
BAKER CARY L. Chief Financial Officer		Direct		22 Mar 2024	2,698
MECKLAI HUSSEIN Chief Operating Officer		Direct		22 Mar 2024	3,678
DOSSETT JEFFREY JOHN Officer	Sale at price 119.08 - 119.87 per share.	Direct	358,430	19 Mar 2024	3,000
DOSSETT JEFFREY JOHN Officer	Conversion of Exercise of derivative security at price 22.40 per share.	Direct	67,200	19 Mar 2024	3,000
DOSSETT JEFFREY JOHN Officer	Sale at price 120.67 - 130.15 per share.	Direct	1,199,073	18 Mar 2024	9,732
DOSSETT JEFFREY JOHN Officer	Conversion of Exercise of derivative security at price 22.40 per share.	Direct	201,600	18 Mar 2024	10,875
DIORIO CHRIS PH.D Chief Executive Officer	Sale at price 123.48 - 124.38 per share.	Direct	75,620	18 Mar 2024	612
BAKER CARY L. Chief Financial Officer	Sale at price 123.55 per share.	Direct	37,806	18 Mar 2024	306
MECKLAI HUSSEIN Chief Operating Officer	Sale at price 124.12 - 124.57 per share.	Direct	60,822	18 Mar 2024	489
DIORIO CHRIS PH.D Chief Executive Officer		Direct		15 Mar 2024	1,562
BAKER CARY L. Chief Financial Officer		Direct		15 Mar 2024	781
MECKLAI HUSSEIN Chief Operating Officer		Direct		15 Mar 2024	1,250
DIORIO CHRIS PH.D Chief Executive Officer	Sale at price 105.00 per share.	Direct	525,000	27 Feb 2024	5,000
DIORIO CHRIS PH.D Chief Executive Officer	Conversion of Exercise of derivative security at price 21.81 per share.	Direct	109,050	27 Feb 2024	5,000
DIORIO CHRIS PH.D Chief Executive Officer	Sale at price 100.49 - 105.00 per share.	Direct	2,149,633	26 Feb 2024	21,060
DIORIO CHRIS PH.D Chief Executive Officer	Conversion of Exercise of derivative security at price 21.81 per share.	Direct	109,050	26 Feb 2024	5,000
BAKER CARY L. Chief Financial Officer	Sale at price 100.49 - 103.68 per share.	Direct	639,398	26 Feb 2024	6,284
DOSSETT JEFFREY JOHN Officer	Sale at price 100.48 - 102.49 per share.	Direct	491,210	23 Feb 2024	4,858
BAKER CARY L. Chief Financial Officer		Direct		23 Feb 2024	3,750
MECKLAI HUSSEIN Chief Operating Officer	Sale at price 100.50 - 102.45 per share.	Direct	730,026	23 Feb 2024	7,217
DOSSETT JEFFREY JOHN Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	22 Feb 2024	15,850
DIORIO CHRIS PH.D Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	22 Feb 2024	41,185
BAKER CARY L. Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	22 Feb 2024	12,375
MECKLAI HUSSEIN Chief Operating Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	22 Feb 2024	18,500
PHELAN CATHAL G Officer and Director	Sale at price 98.88 per share.	Direct	252,745	21 Feb 2024	2,556
PHELAN CATHAL G Officer and Director		Direct		20 Feb 2024	5,500
DIORIO CHRIS PH.D Chief Executive Officer	Sale at price 105.00 - 105.32 per share.	Direct	1,051,618	16 Feb 2024	10,000
DIORIO CHRIS PH.D Chief Executive Officer	Conversion of Exercise of derivative security at price 21.81 per share.	Direct	218,100	16 Feb 2024	10,000
PHELAN CATHAL G Officer and Director	Sale at price 106.23 per share.	Direct	1,062,289	15 Feb 2024	10,000
PHELAN CATHAL G Officer and Director	Conversion of Exercise of derivative security at price 25.78 per share.	Direct	257,800	15 Feb 2024	10,000
BAKER CARY L. Chief Financial Officer	Sale at price 101.10 - 102.67 per share.	Direct	2,042,755	14 Feb 2024	20,000
BAKER CARY L. Chief Financial Officer	Conversion of Exercise of derivative security at price 26.84 - 33.73 per share.	Direct	638,793	14 Feb 2024	20,000
MECKLAI HUSSEIN Chief Operating Officer	Sale at price 104.38 - 105.10 per share.	Direct	3,143,865	12 Feb 2024	30,000
MECKLAI HUSSEIN Chief Operating Officer	Conversion of Exercise of derivative security at price 17.75 - 36.20 per share.	Direct	595,960	12 Feb 2024	30,000
DOSSETT JEFFREY JOHN Officer	Sale at price 81.13 - 81.54 per share.	Direct	30,115	16 Jan 2024	371
DIORIO CHRIS PH.D Chief Executive Officer	Sale at price 81.07 - 81.54 per share.	Direct	69,394	16 Jan 2024	855
BAKER CARY L. Chief Financial Officer	Sale at price 81.16 - 81.61 per share.	Direct	22,572	16 Jan 2024	278
MECKLAI HUSSEIN Chief Operating Officer	Sale at price 81.10 - 81.54 per share.	Direct	26,368	16 Jan 2024	325
DOSSETT JEFFREY JOHN Officer		Direct		12 Jan 2024	1,250
DIORIO CHRIS PH.D Chief Executive Officer		Direct		12 Jan 2024	3,125
BAKER CARY L. Chief Financial Officer		Direct		12 Jan 2024	937
MECKLAI HUSSEIN Chief Operating Officer		Direct		12 Jan 2024	1,094
DOSSETT JEFFREY JOHN Officer	Sale at price 89.75 per share.	Direct	32,488	26 Dec 2023	362
DIORIO CHRIS PH.D Chief Executive Officer	Sale at price 89.76 per share.	Direct	89,846	26 Dec 2023	1,001
BAKER CARY L. Chief Financial Officer	Sale at price 89.64 per share.	Direct	27,071	26 Dec 2023	302
MECKLAI HUSSEIN Chief Operating Officer	Sale at price 89.73 per share.	Direct	54,109	26 Dec 2023	603
DOSSETT JEFFREY JOHN Officer		Direct		22 Dec 2023	937
DIORIO CHRIS PH.D Chief Executive Officer		Direct		22 Dec 2023	2,594
BAKER CARY L. Chief Financial Officer		Direct		22 Dec 2023	781
MECKLAI HUSSEIN Chief Operating Officer		Direct		22 Dec 2023	1,562
DOSSETT JEFFREY JOHN Officer	Sale at price 88.83 per share.	Direct	65,644	18 Dec 2023	739
DOSSETT JEFFREY JOHN Officer	Conversion of Exercise of derivative security at price 22.40 per share.	Direct	74,592	18 Dec 2023	5,205
DIORIO CHRIS PH.D Chief Executive Officer	Sale at price 88.79 - 89.34 per share.	Direct	54,726	18 Dec 2023	616
BAKER CARY L. Chief Financial Officer	Sale at price 88.84 per share.	Direct	27,364	18 Dec 2023	308
MECKLAI HUSSEIN Chief Operating Officer	Sale at price 88.80 - 89.34 per share.	Direct	43,979	18 Dec 2023	495
DIORIO CHRIS PH.D Chief Executive Officer		Direct		15 Dec 2023	1,563
BAKER CARY L. Chief Financial Officer		Direct		15 Dec 2023	781
MECKLAI HUSSEIN Chief Operating Officer		Direct		15 Dec 2023	1,250
DIORIO CHRIS PH.D Chief Executive Officer	Stock Gift at price 0.00 per share.	Direct	0	08 Dec 2023	12,500
BAKER CARY L. Chief Financial Officer	Sale at price 82.94 per share.	Direct	121,749	27 Nov 2023	1,468
BAKER CARY L. Chief Financial Officer		Direct		24 Nov 2023	3,750
SYLEBRA CAPITAL LTD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 82.91 per share.	Indirect	3,110,203	20 Nov 2023	37,513
SYLEBRA CAPITAL LTD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 81.01 per share.	Indirect	3,341,825	17 Nov 2023	41,252
SYLEBRA CAPITAL LTD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 79.61 per share.	Indirect	2,826,951	16 Nov 2023	35,510
SYLEBRA CAPITAL LTD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 79.97 per share.	Indirect	4,199,864	15 Nov 2023	52,518
SYLEBRA CAPITAL LTD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 79.44 per share.	Indirect	3,837,826	14 Nov 2023	48,311
SYLEBRA CAPITAL LTD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 73.16 per share.	Indirect	2,464,175	13 Nov 2023	33,682
DIORIO CHRIS PH.D Chief Executive Officer	Stock Gift at price 0.00 per share.	Direct	0	30 Oct 2023	43,000
DOSSETT JEFFREY JOHN Officer	Sale at price 62.08 per share.	Direct	62,080	26 Oct 2023	1,000
DOSSETT JEFFREY JOHN Officer	Sale at price 52.37 per share.	Direct	26,080	13 Oct 2023	498
DIORIO CHRIS PH.D Chief Executive Officer	Sale at price 52.39 per share.	Direct	65,227	13 Oct 2023	1,245
BAKER CARY L. Chief Financial Officer	Sale at price 52.26 per share.	Direct	19,596	13 Oct 2023	375
MECKLAI HUSSEIN Chief Operating Officer	Sale at price 52.40 per share.	Direct	22,846	13 Oct 2023	436
DOSSETT JEFFREY JOHN Officer		Direct		12 Oct 2023	1,250
DIORIO CHRIS PH.D Chief Executive Officer		Direct		12 Oct 2023	3,125
BAKER CARY L. Chief Financial Officer		Direct		12 Oct 2023	938
MECKLAI HUSSEIN Chief Operating Officer		Direct		12 Oct 2023	1,094
PHELAN CATHAL G Officer and Director	Sale at price 52.79 - 53.91 per share.	Direct	57,657	02 Oct 2023	1,082
PHELAN CATHAL G Officer and Director		Direct		29 Sept 2023	2,000
DOSSETT JEFFREY JOHN Officer	Sale at price 55.15 per share.	Direct	20,187	25 Sept 2023	366
DIORIO CHRIS PH.D Chief Executive Officer	Sale at price 55.20 per share.	Direct	55,753	25 Sept 2023	1,010
BAKER CARY L. Chief Financial Officer	Sale at price 55.21 per share.	Direct	16,839	25 Sept 2023	305
MECKLAI HUSSEIN Chief Operating Officer	Sale at price 55.15 per share.	Direct	33,589	25 Sept 2023	609
DOSSETT JEFFREY JOHN Officer		Direct		22 Sept 2023	938
DIORIO CHRIS PH.D Chief Executive Officer		Direct		22 Sept 2023	2,594
BAKER CARY L. Chief Financial Officer		Direct		22 Sept 2023	781
MECKLAI HUSSEIN Chief Operating Officer		Direct		22 Sept 2023	1,563
DOSSETT JEFFREY JOHN Officer	Sale at price 63.21 per share.	Direct	47,156	18 Sept 2023	746
DIORIO CHRIS PH.D Chief Executive Officer	Sale at price 63.22 per share.	Direct	39,324	18 Sept 2023	622
BAKER CARY L. Chief Financial Officer	Sale at price 63.26 per share.	Direct	19,674	18 Sept 2023	311
MECKLAI HUSSEIN Chief Operating Officer	Sale at price 63.25 per share.	Direct	31,563	18 Sept 2023	499
DOSSETT JEFFREY JOHN Officer		Direct		15 Sept 2023	1,875
DIORIO CHRIS PH.D Chief Executive Officer		Direct		15 Sept 2023	1,562
BAKER CARY L. Chief Financial Officer		Direct		15 Sept 2023	781
MECKLAI HUSSEIN Chief Operating Officer		Direct		15 Sept 2023	1,249
DOSSETT JEFFREY JOHN Officer	Sale at price 70.00 per share.	Direct	140,000	06 Sept 2023	2,000
DOSSETT JEFFREY JOHN Officer	Sale at price 67.79 per share.	Direct	67,790	01 Sept 2023	1,000
SYLEBRA CAPITAL LTD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 66.11 per share.	Indirect	5,247,151	31 Aug 2023	79,370
SYLEBRA CAPITAL LTD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 63.32 per share.	Indirect	8,005,358	30 Aug 2023	126,427
SYLEBRA CAPITAL LTD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 63.27 per share.	Indirect	1,808,193	29 Aug 2023	28,579
BAKER CARY L. Chief Financial Officer	Sale at price 60.21 per share.	Direct	89,409	25 Aug 2023	1,485
BAKER CARY L. Chief Financial Officer		Direct		24 Aug 2023	3,750
SYLEBRA CAPITAL LTD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 59.49 per share.	Indirect	4,448,127	22 Aug 2023	74,771
SYLEBRA CAPITAL LTD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 58.45 per share.	Indirect	2,815,595	21 Aug 2023	48,171
SYLEBRA CAPITAL LTD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 60.02 per share.	Indirect	11,437,951	16 Aug 2023	190,569
SYLEBRA CAPITAL LTD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 61.20 per share.	Indirect	13,781,138	15 Aug 2023	225,182
SYLEBRA CAPITAL LTD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 60.51 per share.	Indirect	3,852,793	14 Aug 2023	63,672
SYLEBRA CAPITAL LTD Beneficial Owner of more than 10% of a Class of Security	Purchase at price 58.26 per share.	Indirect	15,365,492	11 Aug 2023	263,740
DOSSETT JEFFREY JOHN Officer	Sale at price 65.27 - 65.50 per share.	Direct	106,492	01 Aug 2023	1,628
MECKLAI HUSSEIN Chief Operating Officer	Sale at price 65.31 per share.	Direct	16,393	01 Aug 2023	251
DOSSETT JEFFREY JOHN Officer		Direct		31 Jul 2023	1,563
MECKLAI HUSSEIN Chief Operating Officer		Direct		31 Jul 2023	625
DOSSETT JEFFREY JOHN Officer	Sale at price 89.83 per share.	Direct	43,299	13 Jul 2023	482
DIORIO CHRIS PH.D Chief Executive Officer	Sale at price 89.74 per share.	Direct	108,048	13 Jul 2023	1,204
BAKER CARY L. Chief Financial Officer	Sale at price 89.86 per share.	Direct	32,441	13 Jul 2023	361
MECKLAI HUSSEIN Chief Operating Officer	Sale at price 89.77 per share.	Direct	37,793	13 Jul 2023	421
DOSSETT JEFFREY JOHN Officer		Direct		12 Jul 2023	1,250
DIORIO CHRIS PH.D Chief Executive Officer		Direct		12 Jul 2023	3,125
BAKER CARY L. Chief Financial Officer		Direct		12 Jul 2023	937
MECKLAI HUSSEIN Chief Operating Officer		Direct		12 Jul 2023	1,093
PHELAN CATHAL G Officer and Director	Sale at price 90.04 - 90.69 per share.	Direct	93,928	03 Jul 2023	1,042
DOSSETT JEFFREY JOHN Officer	Sale at price 89.70 per share.	Direct	313,950	03 Jul 2023	3,500
DIORIO CHRIS PH.D Chief Executive Officer	Sale at price 89.59 - 90.28 per share.	Direct	137,886	03 Jul 2023	1,536
PHELAN CATHAL G Officer and Director		Direct		30 Jun 2023	2,000

FTSE 1008,213.49+41.34(+0.51%)

FTSE 25020,164.54+112.24(+0.56%)

AIM771.53+3.42(+0.45%)

GBP/EUR1.1679+0.0027(+0.23%)

GBP/USD1.2579+0.0032(+0.26%)

Bitcoin GBP51,944.12+1,314.22(+2.60%)

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Insider transactions

Insider transactions reported - last two years

FTSE 100
8,213.49
+41.34(+0.51%)

FTSE 250
20,164.54
+112.24(+0.56%)

AIM
771.53
+3.42(+0.45%)

GBP/EUR
1.1679
+0.0027(+0.23%)

GBP/USD
1.2579
+0.0032(+0.26%)

Bitcoin GBP
51,944.12
+1,314.22(+2.60%)