Insider	Transaction	Type	Value	Date	Shares
BRAUNSTEIN SCOTT N. Chief Executive Officer	Conversion of Exercise of derivative security at price 4.28 per share.	Direct	214,000	27 Mar 2024	50,000
MANNING MARTHA E General Counsel	Sale at price 9.57 per share.	Direct	18,126	20 Feb 2024	1,894
SHAFER CHRISTINA Officer	Sale at price 9.56 per share.	Direct	20,583	20 Feb 2024	2,153
BRAUNSTEIN SCOTT N. Chief Executive Officer	Sale at price 9.94 per share.	Direct	117,789	16 Feb 2024	11,850
HULIHAN JOSEPH M.D. Officer	Sale at price 9.98 per share.	Direct	28,084	16 Feb 2024	2,814
PFANSTIEL STEVEN Chief Operating Officer	Sale at price 9.97 per share.	Direct	30,827	16 Feb 2024	3,092
MANNING MARTHA E General Counsel	Stock Award(Grant) at price 0.00 per share.	Direct	0	18 Jan 2024	21,835
MAYLEBEN TIMOTHY M Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	18 Jan 2024	4,600
EZICKSON ELAN Z Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	18 Jan 2024	4,600
FISCHER SETH H Z Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	18 Jan 2024	4,600
BRAUNSTEIN SCOTT N. Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	18 Jan 2024	74,600
NOONBERG SARAH B Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	18 Jan 2024	4,600
SILVERSTEIN CHRISTINE BERNI Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	18 Jan 2024	4,600
HULIHAN JOSEPH M.D. Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	18 Jan 2024	21,835
AUSTIN CHARLES Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	18 Jan 2024	4,600
JOHNSON MARVIN H. Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	18 Jan 2024	4,600
NOCHUR SARASWATHY V. PH.D. Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	18 Jan 2024	4,600
PFANSTIEL STEVEN Chief Operating Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	18 Jan 2024	25,465
SHAFER CHRISTINA Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	18 Jan 2024	21,835
MANNING MARTHA E General Counsel	Sale at price 8.93 - 9.54 per share.	Direct	20,790	08 Aug 2023	2,180
BRAUNSTEIN SCOTT N. Chief Executive Officer	Sale at price 8.94 - 9.55 per share.	Direct	61,512	08 Aug 2023	6,443
HULIHAN JOSEPH M.D. Officer	Sale at price 8.93 - 9.55 per share.	Direct	27,706	08 Aug 2023	2,902
PFANSTIEL STEVEN Chief Operating Officer	Sale at price 8.93 - 9.54 per share.	Direct	26,742	08 Aug 2023	2,804
SHAFER CHRISTINA Officer	Sale at price 8.93 - 9.52 per share.	Direct	22,803	08 Aug 2023	2,396
NOONBERG SARAH B Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	16 May 2023	7,200
JOHNSON MARVIN H. Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	17 Apr 2023	7,200
EZICKSON ELAN Z Director	Sale at price 6.56 per share.	Direct	4,920	06 Feb 2023	750
FISCHER SETH H Z Director	Sale at price 6.54 per share.	Direct	6,658	06 Feb 2023	1,018
AUSTIN CHARLES Director	Sale at price 6.49 per share.	Direct	6,964	06 Feb 2023	1,073
MANNING MARTHA E General Counsel	Stock Award(Grant) at price 0.00 per share.	Direct	0	26 Jan 2023	16,548
MAYLEBEN TIMOTHY M Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	26 Jan 2023	3,600
EZICKSON ELAN Z Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	26 Jan 2023	3,600
FISCHER SETH H Z Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	26 Jan 2023	3,600
BRAUNSTEIN SCOTT N. Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	26 Jan 2023	80,000
SILVERSTEIN CHRISTINE BERNI Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	26 Jan 2023	7,200
HULIHAN JOSEPH M.D. Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	26 Jan 2023	25,648
AUSTIN CHARLES Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	26 Jan 2023	3,600
NOCHUR SARASWATHY V. PH.D. Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	26 Jan 2023	3,600
PFANSTIEL STEVEN Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	26 Jan 2023	28,130
SHAFER CHRISTINA Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	26 Jan 2023	17,375
MANNING MARTHA E General Counsel	Stock Award(Grant) at price 0.00 per share.	Direct	0	24 May 2022	5,790
BRAUNSTEIN SCOTT N. Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	24 May 2022	19,305
HULIHAN JOSEPH M.D. Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	24 May 2022	7,718
PFANSTIEL STEVEN Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	24 May 2022	7,448
DOUGHERTY MICHAEL R Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	04 Feb 2022	2,750
MANNING MARTHA E General Counsel	Stock Award(Grant) at price 0.00 per share.	Direct	0	04 Feb 2022	12,867
VITULLO NICOLE Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	04 Feb 2022	2,750
MAYLEBEN TIMOTHY M Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	04 Feb 2022	2,750
EZICKSON ELAN Z Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	04 Feb 2022	2,750
FISCHER SETH H Z Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	04 Feb 2022	2,750
BRAUNSTEIN SCOTT N. Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	04 Feb 2022	42,900
ARROYO SANTIAGO Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	04 Feb 2022	2,750
HULIHAN JOSEPH M.D. Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	04 Feb 2022	17,150
AUSTIN CHARLES Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	04 Feb 2022	2,750
NOCHUR SARASWATHY V. PH.D. Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	04 Feb 2022	2,750
PFANSTIEL STEVEN Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	04 Feb 2022	16,550
VITULLO NICOLE Director	Sale at price 15.87 per share.	Indirect	67,448	15 Mar 2021	4,250
SMITH EDWARD F Former	Sale at price 17.80 per share.	Direct	718,337	09 Mar 2021	40,356
SMITH EDWARD F Former	Conversion of Exercise of derivative security at price 4.16 per share.	Direct	149,456	09 Mar 2021	35,927
SMITH EDWARD F Chief Financial Officer	Sale at price 2.05 per share.	Direct	4,879	30 Jan 2020	2,380
BRAUNSTEIN SCOTT N. Chief Executive Officer	Purchase at price 1.62 per share.	Direct	162,000	13 Dec 2019	100,000
SMITH EDWARD F Chief Financial Officer	Sale at price 5.03 per share.	Direct	121,781	16 May 2019	24,211
CASHMAN CHRISTOPHER MICHAEL Chief Executive Officer	Conversion of Exercise of derivative security at price 1.04 per share.	Direct	32,928	18 Mar 2019	31,662
SMITH EDWARD F Chief Financial Officer	Sale at price 3.06 per share.	Direct	7,626	29 Jan 2019	2,492
CASHMAN CHRISTOPHER MICHAEL Chief Executive Officer	Sale at price 3.13 per share.	Direct	25,484	28 Jan 2019	8,142
SMITH EDWARD F Chief Financial Officer	Sale at price 7.91 per share.	Direct	23,730	29 Jan 2018	3,000
CASHMAN CHRISTOPHER MICHAEL Chief Executive Officer	Sale at price 6.28 per share.	Direct	60,074	18 Jan 2018	9,566
BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC Beneficial Owner of more than 10% of a Class of Security	Sale at price 7.11 - 8.64 per share.	Indirect	10,024,801	19 Dec 2017	1,272,547
VITULLO NICOLE Director and Beneficial Owner of more than 10% of a Class of Security	Stock Award(Grant) at price 0.00 per share.	Direct	0	17 Jan 2017	4,500
SMITH EDWARD F Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	17 Jan 2017	25,200
MAYLEBEN TIMOTHY M Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	17 Jan 2017	4,500
CARRAZANA ENRIQUE J Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	17 Jan 2017	28,500
CASHMAN CHRISTOPHER MICHAEL Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	17 Jan 2017	60,600
MEHRA ANAND Beneficial Owner of more than 10% of a Class of Security	Sale at price 1.39 per share.	Indirect	1,042,699	20 Oct 2016	750,683
CANAAN VII L P Beneficial Owner of more than 10% of a Class of Security	Sale at price 1.50 per share.	Indirect	223,731	08 Aug 2016	149,154
CANAAN VII L P Beneficial Owner of more than 10% of a Class of Security	Sale at price 1.50 per share.	Indirect	218,374	04 Aug 2016	145,583
VITULLO NICOLE Director and Beneficial Owner of more than 10% of a Class of Security	Stock Award(Grant) at price 0.00 per share.	Direct	0	03 Aug 2016	3,300
SMITH EDWARD F Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	03 Aug 2016	27,600
MAYLEBEN TIMOTHY M Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	03 Aug 2016	3,300
CARRAZANA ENRIQUE J Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	03 Aug 2016	3,300
CASHMAN CHRISTOPHER MICHAEL Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	03 Aug 2016	56,100
CANAAN VII L P Beneficial Owner of more than 10% of a Class of Security	Sale at price 1.71 per share.	Indirect	41,963	29 Jul 2016	24,540
CANAAN VII L P Beneficial Owner of more than 10% of a Class of Security	Sale at price 1.80 - 1.81 per share.	Indirect	37,264	27 Jul 2016	20,589
CANAAN VII L P Beneficial Owner of more than 10% of a Class of Security	Sale at price 1.86 - 1.94 per share.	Indirect	514,246	25 Jul 2016	270,750
CASHMAN CHRISTOPHER MICHAEL Chief Executive Officer	Conversion of Exercise of derivative security at price 1.04 per share.	Direct	25,671	09 Feb 2016	24,684
CASHMAN CHRISTOPHER MICHAEL Chief Executive Officer	Purchase at price 5.61 per share.	Direct	19,977	06 Nov 2015	3,561
BLOCH STEPHEN M Director	Conversion of Exercise of derivative security at price 1.04 per share.	Direct	41,132	28 Sept 2015	39,550
BLOCH STEPHEN M Director	Conversion of Exercise of derivative security at price 1.04 per share.	Direct	41,132	28 Sept 2015	39,550
MAYLEBEN TIMOTHY M Director	Conversion of Exercise of derivative security at price 1.04 per share.	Direct	44,252	16 Jul 2015	42,550
CASHMAN CHRISTOPHER MICHAEL Chief Executive Officer	Conversion of Exercise of derivative security at price 1.04 per share.	Direct	14,649	01 Jul 2015	14,086
BLOCH STEPHEN M Director	Stock Gift at price 0.00 per share.	Direct	0	10 Jun 2015	3,000
BLOCH STEPHEN M Director	Conversion of Exercise of derivative security at price 1.04 per share.	Direct	3,120	10 Jun 2015	3,000
FARFEL GAIL M Officer	Sale at price 9.48 per share.	Direct	284,511	21 Apr 2015	30,000
FARFEL GAIL M Officer	Conversion of Exercise of derivative security at price 1.04 per share.	Direct	31,200	21 Apr 2015	30,000
CASHMAN CHRISTOPHER MICHAEL Chief Executive Officer	Conversion of Exercise of derivative security at price 1.04 per share.	Direct	18,312	06 Mar 2015	17,608
CASHMAN CHRISTOPHER MICHAEL Chief Executive Officer	Conversion of Exercise of derivative security at price 1.04 per share.	Direct	84,063	08 Oct 2014	80,830
DOMAIN PARTNERS VI, L.P. Beneficial Owner of more than 10% of a Class of Security	Purchase at price 8.00 per share.	Indirect	3,357,952	05 Aug 2014	419,744
DOMAIN PARTNERS VI, L.P. Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 0.00 per share.	Indirect	0	05 Aug 2014	2,057,140
DP VI ASSOCIATES L P Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 0.00 per share.	Indirect	0	05 Aug 2014	17,000
BLOCH STEPHEN M Director	Purchase at price 8.00 per share.	Indirect	5,000,000	05 Aug 2014	625,000
BLOCH STEPHEN M Director	Conversion of Exercise of derivative security at price 0.00 per share.	Indirect	0	05 Aug 2014	1,836,400
CANAAN VII L P Director and Beneficial Owner of more than 10% of a Class of Security	Purchase at price 8.00 per share.	Indirect	5,000,000	05 Aug 2014	625,000
CANAAN VII L P Director and Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 0.00 per share.	Indirect	0	05 Aug 2014	1,836,398
MEHRA ANAND Director and Beneficial Owner of more than 10% of a Class of Security	Purchase at price 8.00 per share.	Indirect	6,005,464	05 Aug 2014	750,683
MEHRA ANAND Director and Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 0.00 per share.	Indirect	0	05 Aug 2014	1,375,166

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Insider transactions

Insider transactions reported - last two years

FTSE 100
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