Insider	Transaction	Type	Value	Date	Shares
FAIRMOUNT FUNDS MANAGEMENT LLC Beneficial Owner of more than 10% of a Class of Security	Purchase at price 21.00 per share.	Indirect	9,999,990	22 Jan 2024	476,190
MEISNER LARA Officer	Sale at price 28.02 - 28.35 per share.	Direct	64,343	16 Jun 2023	2,296
MEISNER LARA Officer	Conversion of Exercise of derivative security at price 23.03 per share.	Direct	52,900	16 Jun 2023	2,297
MEISNER LARA Officer	Sale at price 24.21 - 25.03 per share.	Direct	186,136	06 Jun 2023	7,500
MEISNER LARA Officer	Conversion of Exercise of derivative security at price 14.00 - 18.51 per share.	Direct	130,369	06 Jun 2023	7,500
MYERS SCOTT DUNSETH Chief Executive Officer	Purchase at price 25.37 per share.	Direct	101,479	12 Apr 2023	4,000
MYERS SCOTT DUNSETH Chief Executive Officer	Purchase at price 29.15 per share.	Direct	160,324	13 Mar 2023	5,500
MEISNER LARA General Counsel	Sale at price 29.07 per share.	Direct	871,257	09 Mar 2023	29,971
MYERS SCOTT DUNSETH Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	06 Feb 2023	250,000
VIOLIN JONATHAN Chief Executive Officer	Sale at price 36.80 per share.	Direct	1,840,000	02 Feb 2023	50,000
VIOLIN JONATHAN Chief Executive Officer	Sale at price 36.80 per share.	Direct	1,840,000	02 Feb 2023	50,000
VIOLIN JONATHAN Chief Executive Officer	Conversion of Exercise of derivative security at price 0.15 per share.	Direct	7,500	02 Feb 2023	50,000
MEISNER LARA General Counsel	Sale at price 35.66 per share.	Direct	244,021	23 Jan 2023	6,843
MEISNER LARA General Counsel	Conversion of Exercise of derivative security at price 14.00 - 23.03 per share.	Direct	140,690	23 Jan 2023	6,843
KATZ BARRETT Officer	Sale at price 37.01 - 37.21 per share.	Direct	1,078,261	17 Jan 2023	29,000
KATZ BARRETT Officer	Conversion of Exercise of derivative security at price 23.03 per share.	Direct	667,870	17 Jan 2023	29,000
KATZ BARRETT Officer	Sale at price 33.04 - 35.30 per share.	Direct	2,089,472	10 Jan 2023	60,000
KATZ BARRETT Officer	Conversion of Exercise of derivative security at price 23.03 per share.	Direct	1,381,800	10 Jan 2023	60,000
MEISNER LARA General Counsel	Sale at price 28.07 - 29.19 per share.	Direct	493,398	21 Dec 2022	16,926
MEISNER LARA General Counsel	Conversion of Exercise of derivative security at price 23.03 per share.	Direct	389,806	21 Dec 2022	16,926
MEISNER LARA General Counsel	Sale at price 28.08 - 28.44 per share.	Direct	45,311	16 Dec 2022	1,597
MEISNER LARA General Counsel	Conversion of Exercise of derivative security at price 23.03 per share.	Direct	36,779	16 Dec 2022	1,597
MEISNER LARA General Counsel	Sale at price 28.05 - 28.12 per share.	Direct	457,077	14 Dec 2022	16,256
MEISNER LARA General Counsel	Conversion of Exercise of derivative security at price 23.03 per share.	Direct	374,376	14 Dec 2022	16,256
MEISNER LARA General Counsel	Sale at price 22.05 per share.	Direct	179,156	15 Nov 2022	8,125
MEISNER LARA General Counsel	Conversion of Exercise of derivative security at price 14.00 per share.	Direct	113,750	15 Nov 2022	8,125
FAIRMOUNT FUNDS MANAGEMENT LLC Beneficial Owner of more than 10% of a Class of Security	Purchase at price 23.50 per share.	Indirect	9,999,978	17 Aug 2022	425,531
VIOLIN JONATHAN Chief Executive Officer	Sale at price 12.20 per share.	Direct	366,000	01 Jun 2022	30,000
VIOLIN JONATHAN Chief Executive Officer	Sale at price 13.04 per share.	Direct	391,200	02 May 2022	30,000
VIOLIN JONATHAN Chief Executive Officer	Sale at price 18.92 - 18.93 per share.	Direct	567,636	04 Apr 2022	30,000
VIOLIN JONATHAN Chief Executive Officer	Sale at price 17.36 - 17.82 per share.	Direct	529,491	02 Mar 2022	30,000
VIOLIN JONATHAN Chief Executive Officer	Sale at price 18.47 - 19.55 per share.	Direct	572,818	03 Feb 2022	30,000
VIOLIN JONATHAN Chief Executive Officer		Direct		08 Dec 2021	627,564
FRAZIER LIFE SCIENCES PUBLIC FUND, L.P. Beneficial Owner of more than 10% of a Class of Security	Purchase at price 14.39 per share.	Direct	2,878,000	23 Sept 2021	200,000
FAIRMOUNT FUNDS MANAGEMENT LLC Beneficial Owner of more than 10% of a Class of Security	Purchase at price 11.00 per share.	Indirect	9,999,000	21 Sept 2021	909,000
LOGOS GLOBAL MANAGEMENT LLC Beneficial Owner of more than 10% of a Class of Security	Purchase at price 1.05 - 1.16 per share.	Direct	524,139	13 Nov 2020	476,667
LOGOS GLOBAL MASTER FUND, L.P. Beneficial Owner of more than 10% of a Class of Security	Purchase at price 1.05 - 1.16 per share.	Direct	524,139	13 Nov 2020	476,667
LEVERONE JASON A. CPA Chief Financial Officer	Conversion of Exercise of derivative security at price 0.57 per share.	Direct	6,412	13 Mar 2020	11,249
LEVERONE JASON A. CPA Chief Financial Officer	Conversion of Exercise of derivative security at price 0.57 per share.	Direct	1,763	23 Aug 2019	3,093
MARSHALL WILLIAM STUART PH.D. Chief Executive Officer	Stock Award(Grant) at price 1.14 - 2.46 per share.	Direct	4,494	21 Aug 2019	2,500
HUGHES THOMAS E Director	Purchase at price 4.77 per share.	Direct	47,697	11 Oct 2018	10,000
LEVERONE JASON A. CPA Chief Financial Officer	Conversion of Exercise of derivative security at price 0.57 per share.	Direct	16,832	07 Aug 2018	29,530
ATLAS VENTURE FUND LP Director	Purchase at price 5.50 per share.	Indirect	2,999,997	13 Feb 2018	545,454
MARSHALL WILLIAM STUART PH.D. Chief Executive Officer	Conversion of Exercise of derivative security at price 0.57 per share.	Direct	66,016	13 Feb 2018	115,818
LEVY ADAM SCOTT Officer	Purchase at price 5.50 per share.	Direct	49,995	13 Feb 2018	9,090
HUGHES THOMAS E Director	Sale at price 8.00 per share.	Direct	96,000	20 Dec 2017	12,000
LEVY ADAM SCOTT Officer	Purchase at price 7.55 per share.	Direct	1,510	22 Jun 2017	200
HUGHES THOMAS E Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	24 Mar 2017	778
LEFKOFF KYLE A Director	Sale at price 14.31 - 14.38 per share.	Indirect	83,190	10 Mar 2017	5,800
LEFKOFF KYLE A Director	Sale at price 14.70 - 16.24 per share.	Indirect	230,977	08 Mar 2017	15,000
LEFKOFF KYLE A Director	Sale at price 13.54 - 14.04 per share.	Indirect	142,519	28 Feb 2017	10,258
LEFKOFF KYLE A Director	Sale at price 13.65 - 14.36 per share.	Indirect	83,452	23 Feb 2017	5,902
LEBOW BENNETT S Director and Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 5.39 per share.	Direct	1,504,171	13 Feb 2017	279,067
GONYER DAVID A Director	Conversion of Exercise of derivative security at price 7.65 per share.	Direct	9,180	08 Feb 2017	1,200
LEBOW BENNETT S Director and Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 7.65 per share.	Direct	9,180	03 Feb 2017	1,200
SEYMOUR TAMARA A Chief Financial Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Indirect	0	31 Oct 2016	146,000
RICCITELLI SAMUEL D Chief Executive Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	31 Oct 2016	200,000
SEYMOUR TAMARA A Chief Financial Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Indirect	0	08 Aug 2016	23,000
RICCITELLI SAMUEL D Chief Executive Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	28 Jun 2016	124,251
RICCITELLI SAMUEL D Chief Executive Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	11 Feb 2016	124,252
RICCITELLI SAMUEL D Chief Executive Officer	Purchase at price 0.78 - 0.80 per share.	Direct	11,060	20 Nov 2015	14,000
LEBOW BENNETT S Director and Beneficial Owner of more than 10% of a Class of Security	Stock Award(Grant) at price 0.00 per share.	Direct	0	06 Aug 2015	5,000
SMITH ROBIN L Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	06 Aug 2015	5,000
SMITH ROBIN L Director	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	06 Aug 2015	4,125
SCHULING DOUGLAS A Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	06 Aug 2015	5,000
SCHULING DOUGLAS A Director	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	06 Aug 2015	4,125
GONYER DAVID A Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	06 Aug 2015	5,000
GONYER DAVID A Director	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	06 Aug 2015	4,125
SEYMOUR TAMARA A Chief Financial Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	04 Aug 2015	23,000
SMITH ROBIN L Director	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	17 Jul 2015	1,375
SCHULING DOUGLAS A Director	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	17 Jul 2015	1,375
GONYER DAVID A Director	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	17 Jul 2015	1,375
RICCITELLI SAMUEL D Chief Executive Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	19 Jun 2015	124,252
RICCITELLI SAMUEL D Chief Executive Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	08 Apr 2015	372,756

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Insider transactions

Insider transactions reported - last two years

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