Insider	Transaction	Type	Value	Date	Shares
SITKO BRADLEY J. Chief Investment Officer	Purchase at price 13.89 - 14.25 per share.	Direct	24,848	03 Oct 2023	1,750
HUGHES OWEN Chief Executive Officer	Purchase at price 13.83 per share.	Direct	13,830	02 Oct 2023	1,000
HUGHES OWEN Chief Executive Officer	Purchase at price 14.43 - 14.65 per share.	Direct	36,075	26 Sept 2023	2,500
SITKO BRADLEY J. Chief Investment Officer	Purchase at price 17.00 - 17.20 per share.	Indirect	25,700	31 May 2023	1,500
SITKO BRADLEY J. Chief Investment Officer	Purchase at price 19.00 per share.	Direct	16,150	23 May 2023	850
SITKO BRADLEY J. Chief Investment Officer	Purchase at price 19.50 per share.	Direct	19,500	19 May 2023	1,000
SITKO BRADLEY J. Chief Investment Officer	Purchase at price 18.66 - 19.00 per share.	Indirect	37,985	12 May 2023	2,000
BVF PARTNERS L.P. Beneficial Owner of more than 10% of a Class of Security	Purchase at price 18.39 - 21.98 per share.	Indirect	420,737	06 Jan 2023	22,249
BVF PARTNERS L P Beneficial Owner of more than 10% of a Class of Security	Purchase at price 16.50 - 16.89 per share.	Indirect	409,309	27 Sept 2022	24,642
BVF PARTNERS L P Beneficial Owner of more than 10% of a Class of Security	Purchase at price 17.25 - 17.96 per share.	Indirect	1,035,418	16 Sept 2022	58,808
NEAL JAMES R Chief Executive Officer	Sale at price 29.55 - 31.86 per share.	Direct	746,104	15 Jul 2022	25,000
NEAL JAMES R Chief Executive Officer	Conversion of Exercise of derivative security at price 4.03 per share.	Direct	100,750	15 Jul 2022	25,000
BURNS THOMAS M Chief Financial Officer	Sale at price 31.66 per share.	Direct	63,321	15 Jul 2022	2,000
BURNS THOMAS M Chief Financial Officer	Conversion of Exercise of derivative security at price 4.03 per share.	Direct	8,060	15 Jul 2022	2,000
NEAL JAMES R Chief Executive Officer	Sale at price 29.00 - 30.02 per share.	Direct	1,553,807	23 Mar 2022	53,450
NEAL JAMES R Chief Executive Officer	Conversion of Exercise of derivative security at price 4.03 per share.	Direct	215,404	23 Mar 2022	53,450
BURNS THOMAS M Chief Financial Officer	Sale at price 29.00 - 30.02 per share.	Direct	423,099	23 Mar 2022	14,500
BURNS THOMAS M Chief Financial Officer	Conversion of Exercise of derivative security at price 4.03 per share.	Direct	58,435	23 Mar 2022	14,500
NEAL JAMES R Chief Executive Officer	Sale at price 33.36 - 35.13 per share.	Direct	303,474	25 Jun 2021	9,027
BVF PARTNERS L P Beneficial Owner of more than 10% of a Class of Security	Sale at price 38.36 per share.	Indirect	24,999,212	31 Mar 2021	651,700
VAN NESS W DENMAN Director	Conversion of Exercise of derivative security at price 4.03 - 19.40 per share.	Direct	59,332	15 Mar 2021	5,699
NEAL JAMES R Chief Executive Officer	Sale at price 41.15 - 42.04 per share.	Direct	1,074,998	15 Dec 2020	26,000
NEAL JAMES R Chief Executive Officer	Conversion of Exercise of derivative security at price 5.50 per share.	Direct	143,000	15 Dec 2020	26,000
BURNS THOMAS M Chief Financial Officer	Sale at price 41.02 - 42.04 per share.	Direct	621,086	15 Dec 2020	15,000
BURNS THOMAS M Chief Financial Officer	Conversion of Exercise of derivative security at price 4.03 per share.	Direct	60,450	15 Dec 2020	15,000
PERRY MATTHEW D Director and Beneficial Owner of more than 10% of a Class of Security	Purchase at price 37.98 per share.	Direct	7,596,000	11 Dec 2020	200,000
NEAL JAMES R Chief Executive Officer	Sale at price 32.46 - 33.35 per share.	Direct	656,184	23 Nov 2020	20,000
NEAL JAMES R Chief Executive Officer	Conversion of Exercise of derivative security at price 5.50 per share.	Direct	110,000	23 Nov 2020	20,000
BURNS THOMAS M Chief Financial Officer	Sale at price 32.46 - 33.35 per share.	Direct	392,308	23 Nov 2020	12,000
BURNS THOMAS M Chief Financial Officer	Conversion of Exercise of derivative security at price 4.03 per share.	Direct	48,360	23 Nov 2020	12,000
NEAL JAMES R Chief Executive Officer	Sale at price 25.90 - 27.50 per share.	Direct	260,205	05 Nov 2020	10,000
NEAL JAMES R Chief Executive Officer	Conversion of Exercise of derivative security at price 5.50 per share.	Direct	55,000	05 Nov 2020	10,000
BURNS THOMAS M Chief Financial Officer	Sale at price 25.98 - 27.50 per share.	Direct	208,908	05 Nov 2020	8,000
BURNS THOMAS M Chief Financial Officer	Conversion of Exercise of derivative security at price 4.03 per share.	Direct	32,240	05 Nov 2020	8,000
BVF PARTNERS L P Beneficial Owner of more than 10% of a Class of Security	Purchase at price 18.20 - 18.45 per share.	Indirect	941,963	23 Sept 2020	51,368
BVF PARTNERS L.P. Beneficial Owner of more than 10% of a Class of Security	Purchase at price 18.77 per share.	Indirect	145,228	04 Sept 2020	7,737
BVF PARTNERS L.P. Beneficial Owner of more than 10% of a Class of Security	Purchase at price 18.48 - 19.17 per share.	Indirect	666,484	01 Sept 2020	35,621
BVF PARTNERS L P Beneficial Owner of more than 10% of a Class of Security	Purchase at price 19.31 - 19.75 per share.	Indirect	546,650	25 Aug 2020	28,175
BVF PARTNERS L P Beneficial Owner of more than 10% of a Class of Security	Purchase at price 19.12 - 19.70 per share.	Indirect	120,004	20 Aug 2020	6,163
BVF PARTNERS L.P. Beneficial Owner of more than 10% of a Class of Security	Purchase at price 17.34 - 18.69 per share.	Indirect	498,736	14 Aug 2020	27,022
BVF PARTNERS L P Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 13.00 per share.	Indirect	16,286,036	15 Apr 2020	1,252,772
BVF PARTNERS L P Beneficial Owner of more than 10% of a Class of Security	Purchase at price 17.20 per share.	Indirect	142,129	25 Mar 2020	8,264
NEAL JAMES R Chief Executive Officer	Purchase at price 14.50 per share.	Direct	14,500	23 Mar 2020	1,000
NEAL JAMES R Chief Executive Officer	Purchase at price 16.41 per share.	Direct	16,410	20 Mar 2020	1,000
BVF PARTNERS L P Beneficial Owner of more than 10% of a Class of Security	Purchase at price 14.52 per share.	Indirect	64,475	18 Mar 2020	4,439
BVF PARTNERS L P Beneficial Owner of more than 10% of a Class of Security	Purchase at price 15.73 - 18.34 per share.	Indirect	2,121,654	17 Mar 2020	118,277
NEAL JAMES R Chief Executive Officer	Conversion of Exercise of derivative security at price 22.00 per share.	Direct	25,960	23 Dec 2019	1,180
BVF PARTNERS L P Beneficial Owner of more than 10% of a Class of Security	Purchase at price 22.00 per share.	Indirect	8,210,290	19 Dec 2019	373,195
BVF PARTNERS L P Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 22.00 per share.	Indirect	10,389,896	18 Dec 2019	472,268
NEAL JAMES R Chief Executive Officer	Sale at price 22.00 per share.	Direct	95,656	06 Nov 2019	4,348
NEAL JAMES R Chief Executive Officer	Conversion of Exercise of derivative security at price 5.50 per share.	Direct	23,914	06 Nov 2019	4,348
NEAL JAMES R Chief Executive Officer	Sale at price 20.23 - 21.96 per share.	Direct	328,928	20 Sept 2019	15,652
NEAL JAMES R Chief Executive Officer	Conversion of Exercise of derivative security at price 5.50 per share.	Direct	86,086	20 Sept 2019	15,652
BURNS THOMAS M Chief Financial Officer	Sale at price 21.35 - 21.96 per share.	Direct	173,387	19 Sept 2019	8,000
BURNS THOMAS M Chief Financial Officer	Conversion of Exercise of derivative security at price 4.03 per share.	Direct	32,240	19 Sept 2019	8,000
BVF PARTNERS L P Beneficial Owner of more than 10% of a Class of Security	Purchase at price 14.36 - 14.74 per share.	Indirect	408,228	14 May 2019	27,913
VAN NESS W DENMAN Director	Sale at price 14.71 per share.	Indirect	1,912	10 May 2019	130
VAN NESS W DENMAN Director	Conversion of Exercise of derivative security at price 13.00 per share.	Direct	10,400	20 Dec 2018	800
NEAL JAMES R Chief Executive Officer	Conversion of Exercise of derivative security at price 13.00 per share.	Direct	8,814	20 Dec 2018	678
BVF PARTNERS L P Beneficial Owner of more than 10% of a Class of Security	Purchase at price 14.19 per share.	Indirect	354,792	17 Dec 2018	25,000
BVF PARTNERS L P Beneficial Owner of more than 10% of a Class of Security	Purchase at price 14.41 - 14.75 per share.	Indirect	527,242	13 Dec 2018	36,463
BVF PARTNERS L P Beneficial Owner of more than 10% of a Class of Security	Purchase at price 14.54 - 14.80 per share.	Indirect	897,448	10 Dec 2018	61,023
BVF PARTNERS L P Beneficial Owner of more than 10% of a Class of Security	Purchase at price 14.85 - 14.99 per share.	Direct	146,139	04 Dec 2018	9,800
BVF PARTNERS L P Beneficial Owner of more than 10% of a Class of Security	Purchase at price 14.93 - 15.24 per share.	Indirect	448,484	29 Nov 2018	29,700
BVF PARTNERS L P Beneficial Owner of more than 10% of a Class of Security	Purchase at price 13.68 - 15.00 per share.	Direct	1,023,658	21 Nov 2018	72,253
BVF PARTNERS L P Beneficial Owner of more than 10% of a Class of Security	Purchase at price 13.31 - 13.82 per share.	Indirect	431,348	16 Nov 2018	31,990
VAN NESS W DENMAN Director	Sale at price 12.67 per share.	Direct	70,040	15 Nov 2018	5,528
VAN NESS W DENMAN Director	Conversion of Exercise of derivative security at price 4.03 - 11.20 per share.	Direct	52,699	15 Nov 2018	7,693
NEAL JAMES R Chief Executive Officer	Purchase at price 13.26 per share.	Direct	53,056	13 Nov 2018	4,000
NEAL JAMES R Chief Executive Officer	Sale at price 24.42 - 24.69 per share.	Direct	588,285	27 Apr 2018	24,000
NEAL JAMES R Chief Executive Officer	Conversion of Exercise of derivative security at price 5.50 per share.	Direct	132,000	27 Apr 2018	24,000
BURNS THOMAS M Chief Financial Officer	Sale at price 24.69 - 24.77 per share.	Direct	271,807	27 Apr 2018	11,000
BURNS THOMAS M Chief Financial Officer	Conversion of Exercise of derivative security at price 5.50 per share.	Direct	60,500	27 Apr 2018	11,000
NEAL JAMES R Chief Executive Officer	Sale at price 27.00 - 31.77 per share.	Direct	1,307,187	15 Nov 2017	46,296
NEAL JAMES R Chief Executive Officer	Conversion of Exercise of derivative security at price 4.03 per share.	Direct	186,573	15 Nov 2017	46,296
BURNS THOMAS M Chief Financial Officer	Sale at price 27.04 - 31.77 per share.	Direct	637,450	15 Nov 2017	22,222
BURNS THOMAS M Chief Financial Officer	Conversion of Exercise of derivative security at price 4.03 per share.	Direct	89,555	15 Nov 2017	22,222
VARIAN JOHN W Director	Sale at price 6.24 per share.	Direct	246,919	16 May 2017	39,540
NEAL JAMES R Officer and Director	Sale at price 5.40 per share.	Direct	27,569	21 Mar 2017	5,105
BURNS THOMAS M Chief Financial Officer	Sale at price 5.40 per share.	Direct	14,030	21 Mar 2017	2,598
PERRY MATTHEW D Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	02 Mar 2017	11,799
NEAL JAMES R Officer	Sale at price 4.50 - 4.53 per share.	Direct	880	01 Feb 2017	195
NEAL JAMES R Officer	Sale at price 5.15 per share.	Direct	644	09 Jan 2017	125
VARIAN JOHN W Director	Sale at price 5.75 per share.	Direct	77,907	21 Dec 2016	13,549
SCANNON PATRICK J M.D., PH.D. Officer	Sale at price 5.75 per share.	Direct	18,572	21 Dec 2016	3,230
NEAL JAMES R Officer	Sale at price 5.25 per share.	Direct	788	01 Nov 2016	150
NEAL JAMES R Officer	Sale at price 0.45 per share.	Direct	1,120	07 Oct 2016	2,500
WYSZOMIERSKI JACK L Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	21 Jul 2016	48,246
LIMBER JOSEPH M Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	21 Jul 2016	48,246
VAN NESS W DENMAN Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	21 Jul 2016	48,246
WALBERT TIMOTHY P Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	21 Jul 2016	48,246
WYSZOMIERSKI JACK L Director	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	27 May 2016	2,800
LIMBER JOSEPH M Director	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	27 May 2016	2,800
VAN NESS W DENMAN Director	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	27 May 2016	3,150
WALBERT TIMOTHY P Director	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	27 May 2016	2,800
VARIAN JOHN W Chief Executive Officer	Sale at price 0.78 per share.	Direct	63,578	22 Mar 2016	81,022
SCANNON PATRICK J M.D., PH.D. Officer and Director	Sale at price 0.78 per share.	Direct	11,602	22 Mar 2016	14,785
RUBIN PAUL D Officer	Sale at price 0.78 per share.	Direct	18,985	22 Mar 2016	24,194
NEAL JAMES R Officer	Sale at price 0.78 per share.	Direct	15,547	22 Mar 2016	19,813
BURNS THOMAS M Chief Financial Officer	Sale at price 0.78 per share.	Direct	15,105	22 Mar 2016	19,249
VARIAN JOHN W Chief Executive Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	18 Mar 2016	36,907
SCANNON PATRICK J M.D., PH.D. Officer and Director	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	18 Mar 2016	9,500
RUBIN PAUL D Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	18 Mar 2016	12,141
VARIAN JOHN W Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	25 Feb 2016	541,600
SCANNON PATRICK J M.D., PH.D. Officer and Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	25 Feb 2016	140,000
RUBIN PAUL D Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	25 Feb 2016	198,330
NEAL JAMES R Divisional Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	25 Feb 2016	248,954
BURNS THOMAS M Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	25 Feb 2016	108,560
SCANNON PATRICK J M.D., PH.D. Officer and Director	Sale at price 1.01 per share.	Direct	8,080	01 Feb 2016	8,000
SCANNON PATRICK J M.D., PH.D. Officer and Director	Sale at price 1.37 per share.	Direct	10,937	28 Dec 2015	8,000
LIMBER JOSEPH M Director	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	11 Dec 2015	5,600
SCANNON PATRICK J M.D., PH.D. Officer and Director	Sale at price 1.35 per share.	Direct	10,800	23 Nov 2015	8,000
SCANNON PATRICK J M.D., PH.D. Officer and Director	Sale at price 1.04 per share.	Direct	8,358	26 Oct 2015	8,000
VARIAN JOHN W Chief Executive Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	14 Aug 2015	94,573
SCANNON PATRICK J M.D., PH.D. Officer and Director	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	14 Aug 2015	16,264
RUBIN PAUL D Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	14 Aug 2015	26,748
BAKER BROTHERS LIFE SCIENCES L P Unknown	Sale at price 1.09 per share.	Indirect	12,017,496	22 Jul 2015	10,999,996
VARIAN JOHN W Chief Executive Officer	Sale at price 4.49 per share.	Direct	44,869	15 Jul 2015	10,000
VARIAN JOHN W Chief Executive Officer	Conversion of Exercise of derivative security at price 1.24 per share.	Direct	12,400	15 Jul 2015	10,000
RUBIN PAUL D Officer	Sale at price 4.60 per share.	Direct	22,992	15 Jul 2015	5,000
RUBIN PAUL D Officer	Conversion of Exercise of derivative security at price 3.04 per share.	Direct	15,200	15 Jul 2015	5,000
RUBIN PAUL D Officer	Sale at price 4.55 per share.	Direct	152,005	10 Jul 2015	33,400
RUBIN PAUL D Officer	Conversion of Exercise of derivative security at price 3.04 per share.	Direct	101,536	10 Jul 2015	33,400
VARIAN JOHN W Chief Executive Officer	Sale at price 3.64 per share.	Direct	36,362	15 Jun 2015	10,000
VARIAN JOHN W Chief Executive Officer	Conversion of Exercise of derivative security at price 1.24 per share.	Direct	12,400	15 Jun 2015	10,000
WYSZOMIERSKI JACK L Director	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	28 May 2015	5,600
LIMBER JOSEPH M Director	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	28 May 2015	2,800
BOWES WILLIAM K JR Director	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	28 May 2015	5,600
RUBIN PAUL D Officer	Sale at price 3.60 per share.	Direct	6,437	28 May 2015	1,788
RUBIN PAUL D Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	28 May 2015	4,666
VAN NESS W DENMAN Director	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	28 May 2015	6,300
WALBERT TIMOTHY P Director	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	28 May 2015	5,600
WYSZOMIERSKI JACK L Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	21 May 2015	36,873
LIMBER JOSEPH M Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	21 May 2015	36,873
BOWES WILLIAM K JR Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	21 May 2015	36,873
VAN NESS W DENMAN Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	21 May 2015	36,873
WALBERT TIMOTHY P Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	21 May 2015	36,873
VARIAN JOHN W Chief Executive Officer	Sale at price 3.34 per share.	Direct	33,400	15 May 2015	10,000
VARIAN JOHN W Chief Executive Officer	Conversion of Exercise of derivative security at price 1.24 per share.	Direct	12,400	15 May 2015	10,000
VARIAN JOHN W Chief Executive Officer	Sale at price 3.86 per share.	Direct	38,606	15 Apr 2015	10,000
VARIAN JOHN W Chief Executive Officer	Conversion of Exercise of derivative security at price 1.24 per share.	Direct	12,400	15 Apr 2015	10,000
KURLAND FRED F Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	06 Apr 2015	29,938
RUBIN PAUL D Officer	Sale at price 3.94 per share.	Direct	128,879	23 Mar 2015	32,742
VARIAN JOHN W Chief Executive Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	18 Mar 2015	36,907
SCANNON PATRICK J M.D., PH.D. Officer and Director	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	18 Mar 2015	9,500
RUBIN PAUL D Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	18 Mar 2015	30,346
KURLAND FRED F Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	18 Mar 2015	10,875
KLEIN THOMAS Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	18 Mar 2015	80,667
VARIAN JOHN W Chief Executive Officer	Sale at price 3.72 per share.	Direct	37,223	16 Mar 2015	10,000
VARIAN JOHN W Chief Executive Officer	Conversion of Exercise of derivative security at price 1.24 per share.	Direct	12,400	16 Mar 2015	10,000

NIKKEI 22538,202.37-632.73(-1.63%)

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Bitcoin GBP48,799.98-1,248.82(-2.50%)

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XOMA Corporation (0M26.L)

Insider transactions

Insider transactions reported - last two years

NIKKEI 225
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HANG SENG
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CRUDE OIL
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GOLD FUTURES
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