Insider	Transaction	Type	Value	Date	Shares
ALLOWAY PAUL President		Direct		25 Mar 2024	23,530
ALLOWAY PAUL Officer	Sale at price 0.05 per share.	Direct	14	25 Mar 2024	268
MICHAUD CHARLES JR. Officer and Treasurer		Direct		25 Mar 2024	6,448
MICHAUD CHARLES JR. Officer	Sale at price 0.05 per share.	Direct	4	25 Mar 2024	75
TZIANABOS ARTHUR Director	Sale at price 0.57 per share.	Direct	7,445	09 Jan 2024	13,037
ALLOWAY PAUL President	Sale at price 0.57 per share.	Direct	4,120	03 Jan 2024	7,280
MICHAUD CHARLES JR. Officer and Treasurer	Sale at price 0.57 per share.	Direct	975	03 Jan 2024	1,708
TZIANABOS ARTHUR Director		Direct		29 Dec 2023	33,420
ALLOWAY PAUL President		Direct		29 Dec 2023	18,610
MICHAUD CHARLES JR. Officer and Treasurer		Direct		29 Dec 2023	4,240
SEYMOUR ALBERT B Chief Executive Officer	Sale at price 1.15 per share.	Direct	1,665	06 Sept 2023	1,448
SEYMOUR ALBERT B Chief Executive Officer		Direct		06 Sept 2023	4,620
JORDAN JULIE Officer	Sale at price 1.39 per share.	Direct	2,576	03 Aug 2023	1,853
JORDAN JULIE Officer		Direct		03 Aug 2023	6,579
JORDAN JULIE Officer	Sale at price 1.31 per share.	Direct	130	02 Aug 2023	99
JORDAN JULIE Officer		Direct		02 Aug 2023	350
ALLOWAY PAUL Officer	Sale at price 1.45 per share.	Direct	15,863	02 Mar 2023	10,965
SMITH W BRADFORD Chief Financial Officer	Sale at price 1.39 per share.	Direct	5,188	09 Jan 2023	3,729
TZIANABOS ARTHUR Director	Sale at price 1.39 per share.	Direct	14,762	09 Jan 2023	10,616
SEYMOUR ALBERT B Chief Executive Officer	Sale at price 1.39 per share.	Direct	5,033	09 Jan 2023	3,620
ALLOWAY PAUL Officer	Sale at price 1.39 per share.	Direct	4,296	09 Jan 2023	3,090
BLUM MICHAEL LEE Officer	Sale at price 1.39 per share.	Direct	3,412	09 Jan 2023	2,454
SMITH W BRADFORD Chief Financial Officer		Direct		30 Dec 2022	13,530
TZIANABOS ARTHUR Director		Direct		30 Dec 2022	33,000
SEYMOUR ALBERT B Chief Executive Officer		Direct		30 Dec 2022	11,220
ALLOWAY PAUL Officer		Direct		30 Dec 2022	9,570
BLUM MICHAEL LEE Officer		Direct		30 Dec 2022	7,590
SMITH W BRADFORD Chief Financial Officer	Sale at price 3.78 per share.	Direct	8,248	05 Jan 2022	2,182
TZIANABOS ARTHUR Chief Executive Officer	Sale at price 3.78 per share.	Direct	20,239	05 Jan 2022	5,354
SEYMOUR ALBERT B Officer	Sale at price 3.78 per share.	Direct	6,279	05 Jan 2022	1,661
KELLY TIMOTHY P Chief Operating Officer	Sale at price 3.78 per share.	Direct	5,315	05 Jan 2022	1,406
COHN GABRIEL Officer	Sale at price 3.78 per share.	Direct	6,279	05 Jan 2022	1,661
SMITH W BRADFORD Chief Financial Officer		Direct		31 Dec 2021	6,600
TZIANABOS ARTHUR Chief Executive Officer		Direct		31 Dec 2021	13,860
SEYMOUR ALBERT B Officer		Direct		31 Dec 2021	4,290
KELLY TIMOTHY P Chief Operating Officer		Direct		31 Dec 2021	3,630
COHN GABRIEL Officer		Direct		31 Dec 2021	4,290
KELLY TIMOTHY P Chief Operating Officer	Sale at price 7.70 per share.	Direct	416	03 Sept 2021	54
KELLY TIMOTHY P Officer	Sale at price 11.16 per share.	Direct	69,563	01 Mar 2021	6,232
KELLY TIMOTHY P Officer	Conversion of Exercise of derivative security at price 2.89 - 6.63 per share.	Direct	19,052	01 Mar 2021	4,000
SMITH W BRADFORD Chief Financial Officer	Sale at price 14.25 per share.	Direct	192,425	08 Feb 2021	13,500
SMITH W BRADFORD Chief Financial Officer	Conversion of Exercise of derivative security at price 0.64 per share.	Direct	8,640	08 Feb 2021	13,500
KELLY TIMOTHY P Chief Technology Officer	Sale at price 13.00 per share.	Direct	6,500	02 Feb 2021	500
KELLY TIMOTHY P Chief Technology Officer	Conversion of Exercise of derivative security at price 6.63 per share.	Direct	3,316	02 Feb 2021	500
KELLY TIMOTHY P Chief Technology Officer	Sale at price 12.37 per share.	Direct	49,460	01 Feb 2021	4,000
KELLY TIMOTHY P Chief Technology Officer	Conversion of Exercise of derivative security at price 2.89 - 6.63 per share.	Direct	19,052	01 Feb 2021	4,000
KELLY TIMOTHY P Chief Technology Officer	Sale at price 13.00 per share.	Direct	6,500	12 Jan 2021	500
KELLY TIMOTHY P Chief Technology Officer	Conversion of Exercise of derivative security at price 6.63 per share.	Direct	3,316	12 Jan 2021	500
SEYMOUR ALBERT B Officer	Sale at price 12.05 - 12.06 per share.	Direct	180,865	07 Jan 2021	15,000
SEYMOUR ALBERT B Officer	Sale at price 11.44 per share.	Direct	114,422	05 Jan 2021	10,000
KELLY TIMOTHY P Chief Technology Officer	Sale at price 11.50 per share.	Direct	45,983	04 Jan 2021	4,000
KELLY TIMOTHY P Chief Technology Officer	Conversion of Exercise of derivative security at price 2.89 - 6.63 per share.	Direct	19,052	04 Jan 2021	4,000
PARMAR KUSH M Director	Sale at price 12.82 per share.	Indirect	6,410,000	22 Dec 2020	500,000
5AM VENTURES IV, L.P. Beneficial Owner of more than 10% of a Class of Security	Sale at price 12.82 per share.	Indirect	6,410,000	22 Dec 2020	500,000
PARMAR KUSH M Director	Sale at price 11.88 - 13.06 per share.	Indirect	6,125,915	14 Dec 2020	500,000
5AM VENTURES IV, L.P. Beneficial Owner of more than 10% of a Class of Security	Sale at price 11.88 - 13.06 per share.	Indirect	6,125,915	14 Dec 2020	500,000
KELLY TIMOTHY P Chief Technology Officer	Sale at price 13.01 per share.	Direct	17,109	17 Mar 2020	1,315
SMITH W BRADFORD Chief Financial Officer	Sale at price 16.16 per share.	Direct	193,866	03 Feb 2020	12,000
SMITH W BRADFORD Chief Financial Officer	Conversion of Exercise of derivative security at price 0.64 per share.	Direct	7,680	03 Feb 2020	12,000
TZIANABOS ARTHUR Chief Executive Officer	Sale at price 16.16 per share.	Direct	202,021	03 Feb 2020	12,500
FLYNN JAMES E Beneficial Owner of more than 10% of a Class of Security	Sale at price 15.45 per share.	Indirect	8,015,844	30 Jan 2020	518,827
FLYNN JAMES E Beneficial Owner of more than 10% of a Class of Security	Sale at price 15.51 - 15.77 per share.	Indirect	10,036,536	28 Jan 2020	639,506
SMITH W BRADFORD Chief Financial Officer	Sale at price 20.50 per share.	Direct	122,984	02 Jan 2020	6,000
SMITH W BRADFORD Chief Financial Officer	Conversion of Exercise of derivative security at price 0.64 per share.	Direct	3,840	02 Jan 2020	6,000
TZIANABOS ARTHUR Chief Executive Officer	Sale at price 20.50 per share.	Direct	256,191	02 Jan 2020	12,500
SEYMOUR ALBERT B Officer	Sale at price 20.50 per share.	Direct	187,216	02 Jan 2020	9,133
FLYNN JAMES E Beneficial Owner of more than 10% of a Class of Security	Sale at price 21.95 per share.	Indirect	7,682,535	24 Dec 2019	350,000
FLYNN JAMES E Beneficial Owner of more than 10% of a Class of Security	Sale at price 21.50 - 21.83 per share.	Indirect	3,587,060	23 Dec 2019	164,730
SMITH W BRADFORD Chief Financial Officer	Sale at price 16.00 - 16.21 per share.	Direct	193,266	02 Dec 2019	12,000
SMITH W BRADFORD Chief Financial Officer	Conversion of Exercise of derivative security at price 0.64 per share.	Direct	7,680	02 Dec 2019	12,000
TZIANABOS ARTHUR Chief Executive Officer	Sale at price 16.04 - 16.25 per share.	Direct	403,735	02 Dec 2019	25,000
SEYMOUR ALBERT B Officer	Sale at price 16.06 - 16.23 per share.	Direct	300,359	02 Dec 2019	18,600
GREGORY RICHARD J Director	Conversion of Exercise of derivative security at price 0.03 per share.	Direct	324	18 Nov 2019	10,806
SMITH W BRADFORD Chief Financial Officer	Sale at price 17.38 - 18.23 per share.	Direct	104,367	01 Oct 2019	6,000
SMITH W BRADFORD Chief Financial Officer	Conversion of Exercise of derivative security at price 0.64 per share.	Direct	3,840	01 Oct 2019	6,000
TZIANABOS ARTHUR Chief Executive Officer	Sale at price 17.39 - 18.23 per share.	Direct	217,468	01 Oct 2019	12,500
SEYMOUR ALBERT B Officer	Sale at price 17.38 - 18.23 per share.	Direct	161,759	01 Oct 2019	9,300
KELLY TIMOTHY P Chief Technology Officer	Sale at price 19.94 per share.	Direct	23,251	05 Sept 2019	1,166
SMITH W BRADFORD Chief Financial Officer	Sale at price 18.74 per share.	Direct	112,419	03 Sept 2019	6,000
SMITH W BRADFORD Chief Financial Officer	Conversion of Exercise of derivative security at price 0.64 per share.	Direct	3,840	03 Sept 2019	6,000
TZIANABOS ARTHUR Chief Executive Officer	Sale at price 18.75 per share.	Direct	234,320	03 Sept 2019	12,500
SEYMOUR ALBERT B Officer	Sale at price 18.74 per share.	Direct	174,284	03 Sept 2019	9,300
SMITH W BRADFORD Chief Financial Officer	Sale at price 17.37 per share.	Direct	104,191	01 Aug 2019	6,000
SMITH W BRADFORD Chief Financial Officer	Conversion of Exercise of derivative security at price 0.64 per share.	Direct	3,840	01 Aug 2019	6,000
TZIANABOS ARTHUR Chief Executive Officer	Sale at price 17.37 per share.	Direct	217,111	01 Aug 2019	12,500
SEYMOUR ALBERT B Officer	Sale at price 17.37 per share.	Direct	161,523	01 Aug 2019	9,300
RASTY SIYAMAK Chief Operating Officer	Sale at price 20.00 per share.	Direct	160,000	09 Jul 2019	8,000
SMITH W BRADFORD Chief Financial Officer	Sale at price 19.00 per share.	Direct	113,971	01 Jul 2019	6,000
SMITH W BRADFORD Chief Financial Officer	Conversion of Exercise of derivative security at price 0.64 per share.	Direct	3,840	01 Jul 2019	6,000
TZIANABOS ARTHUR Chief Executive Officer	Sale at price 18.98 per share.	Direct	237,300	01 Jul 2019	12,500
SEYMOUR ALBERT B Officer	Sale at price 18.98 - 19.56 per share.	Direct	176,539	01 Jul 2019	9,300
SMITH W BRADFORD Chief Financial Officer	Sale at price 19.94 per share.	Direct	119,664	03 Jun 2019	6,000
SMITH W BRADFORD Chief Financial Officer	Conversion of Exercise of derivative security at price 0.64 per share.	Direct	3,840	03 Jun 2019	6,000
TZIANABOS ARTHUR Chief Executive Officer	Sale at price 19.86 per share.	Direct	248,262	03 Jun 2019	12,500
RASTY SIYAMAK Chief Operating Officer	Sale at price 20.22 per share.	Direct	161,778	03 Jun 2019	8,000
SEYMOUR ALBERT B Officer	Sale at price 19.90 per share.	Direct	185,093	03 Jun 2019	9,300
KELLY TIMOTHY P Officer	Sale at price 20.00 per share.	Direct	25,765	03 Jun 2019	1,288
PARMAR KUSH M Director and Beneficial Owner of more than 10% of a Class of Security	Sale at price 21.47 per share.	Indirect	13,204,050	16 May 2019	615,000
5AM VENTURES IV, L.P. Beneficial Owner of more than 10% of a Class of Security	Sale at price 21.47 per share.	Indirect	13,204,050	16 May 2019	615,000
FLYNN JAMES E Director and Beneficial Owner of more than 10% of a Class of Security	Purchase at price 22.50 per share.	Indirect	11,999,992	12 Apr 2019	533,333
PARMAR KUSH M Director and Beneficial Owner of more than 10% of a Class of Security	Sale at price 26.01 per share.	Indirect	405,029	10 Dec 2018	15,575
5AM VENTURES IV, L.P. Beneficial Owner of more than 10% of a Class of Security	Sale at price 26.01 per share.	Indirect	405,029	10 Dec 2018	15,575
PARMAR KUSH M Director and Beneficial Owner of more than 10% of a Class of Security	Sale at price 20.04 per share.	Indirect	594,709	23 Nov 2018	29,682
5AM VENTURES IV, L.P. Beneficial Owner of more than 10% of a Class of Security	Sale at price 20.04 per share.	Indirect	594,709	23 Nov 2018	29,682
PARMAR KUSH M Director and Beneficial Owner of more than 10% of a Class of Security	Sale at price 20.20 per share.	Indirect	10,623,180	16 Nov 2018	525,900
5AM VENTURES IV, L.P. Beneficial Owner of more than 10% of a Class of Security	Sale at price 20.20 per share.	Indirect	10,623,180	16 Nov 2018	525,900
SHAH MAHENDRA G Director	Stock Award(Grant) at price 16.00 per share.	Indirect	8,000,000	02 Apr 2018	500,000
SHAH MAHENDRA G Director		Indirect		02 Apr 2018	659,742
SHAH MAHENDRA G Director	Stock Award(Grant) at price 16.00 per share.	Indirect	4,000,000	02 Apr 2018	250,000
SHAH MAHENDRA G Director		Indirect		02 Apr 2018	659,742
GILLIS STEVEN Director		Indirect		02 Apr 2018	6,068,695
FLYNN JAMES E Director and Beneficial Owner of more than 10% of a Class of Security	Purchase at price 16.00 per share.	Indirect	20,000,000	02 Apr 2018	1,250,000
FLYNN JAMES E Director and Beneficial Owner of more than 10% of a Class of Security		Indirect		02 Apr 2018	3,977,035
ROCK SPRINGS CAPITAL MANAGEMENT, L P. Beneficial Owner of more than 10% of a Class of Security	Purchase at price 16.00 per share.	Indirect	4,000,000	02 Apr 2018	250,000
ROCK SPRINGS CAPITAL MANAGEMENT, L P. Beneficial Owner of more than 10% of a Class of Security		Indirect		02 Apr 2018	395,845
NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. Beneficial Owner of more than 10% of a Class of Security		Indirect		02 Apr 2018	1,979,226
PARMAR KUSH M Director and Beneficial Owner of more than 10% of a Class of Security		Indirect		02 Apr 2018	5,392,037
PARMAR KUSH M Director and Beneficial Owner of more than 10% of a Class of Security		Indirect		02 Apr 2018	5,392,037
TEMASEK HOLDINGS PRIVATE LIMITED Beneficial Owner of more than 10% of a Class of Security	Purchase at price 16.00 per share.	Indirect	10,000,000	02 Apr 2018	625,000
TEMASEK HOLDINGS PRIVATE LIMITED Beneficial Owner of more than 10% of a Class of Security		Indirect		02 Apr 2018	2,595,293
ARCH VENTURE FUND VIII, L.P. Beneficial Owner of more than 10% of a Class of Security		Indirect		02 Apr 2018	6,068,695
VIDA VENTURES, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Purchase at price 16.00 per share.	Indirect	6,000,000	02 Apr 2018	375,000
VIDA VENTURES, L.L.C. Beneficial Owner of more than 10% of a Class of Security		Indirect		02 Apr 2018	395,845
5AM VENTURES IV, L.P. Beneficial Owner of more than 10% of a Class of Security		Indirect		02 Apr 2018	5,392,037

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Insider transactions

Insider transactions reported - last two years

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