Insider	Transaction	Type	Value	Date	Shares
GRYSKA DAVID W Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	11 Jun 2020	1,750
MCGRAW BENJAMIN F III Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	11 Jun 2020	1,750
CAGLE GERALD D Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	11 Jun 2020	1,750
MCHUGH JULIE H Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	11 Jun 2020	1,750
CROARKIN RICHARD Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	11 Jun 2020	1,750
DU TOIT MICHAEL Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	11 Jun 2020	1,750
GOLDBERG MURRAY A Director	Conversion of Exercise of derivative security at price 3.15 per share.	Direct	88,200	18 May 2020	28,000
CAGLE GERALD D Director	Sale at price 15.27 per share.	Direct	76,350	08 May 2020	5,000
FORESITE CAPITAL MANAGEMENT II, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Sale at price 17.07 per share.	Indirect	17,070,000	27 Feb 2020	1,000,000
ANIDO VICENTE JR., PH.D. Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	06 Feb 2020	28,000
MITRO THOMAS A President	Stock Award(Grant) at price 0.00 per share.	Direct	0	06 Feb 2020	14,000
RUBINO RICHARD J Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	06 Feb 2020	11,750
KOPCZYNSKI CASEY C Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	06 Feb 2020	10,000
LAROCCA JOHN General Counsel	Stock Award(Grant) at price 0.00 per share.	Direct	0	06 Feb 2020	3,500
FORESITE CAPITAL MANAGEMENT, IV, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 30.00 per share.	Indirect	867,000	20 Dec 2019	28,900
KOPCZYNSKI CASEY C Officer	Conversion of Exercise of derivative security at price 0.41 per share.	Direct	47,385	03 Dec 2019	117,000
FORESITE CAPITAL MANAGEMENT, IV, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 30.00 per share.	Indirect	930,000	03 Dec 2019	31,000
FORESITE CAPITAL MANAGEMENT, IV, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 30.00 per share.	Indirect	768,000	15 Nov 2019	25,600
HOLLANDER DAVID A Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	11 Nov 2019	25,000
FORESITE CAPITAL MANAGEMENT, IV, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 30.00 per share.	Indirect	4,500	07 Nov 2019	150
LAROCCA JOHN General Counsel	Stock Award(Grant) at price 0.00 per share.	Direct	0	14 Aug 2019	8,000
GRYSKA DAVID W Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	23 May 2019	1,750
GOLDBERG MURRAY A Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	23 May 2019	1,750
MCGRAW BENJAMIN F III Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	23 May 2019	1,750
CAGLE GERALD D Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	23 May 2019	1,750
MCHUGH JULIE H Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	23 May 2019	1,750
CROARKIN RICHARD Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	23 May 2019	1,750
DU TOIT MICHAEL Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	23 May 2019	1,750
ANIDO VICENTE JR., PH.D. Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	16 May 2019	32,171
MITRO THOMAS A President	Stock Award(Grant) at price 0.00 per share.	Direct	0	16 May 2019	13,559
RUBINO RICHARD J Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	16 May 2019	13,559
ANIDO VICENTE JR., PH.D. Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	07 Feb 2019	25,413
MITRO THOMAS A President	Stock Award(Grant) at price 0.00 per share.	Direct	0	07 Feb 2019	12,778
RUBINO RICHARD J Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	07 Feb 2019	10,667
KOPCZYNSKI CASEY C Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	07 Feb 2019	8,000
LAROCCA JOHN General Counsel	Stock Award(Grant) at price 0.00 per share.	Direct	0	07 Feb 2019	7,000
KOPCZYNSKI CASEY C Officer	Sale at price 46.03 - 47.02 per share.	Direct	507,844	01 Feb 2019	11,000
KOPCZYNSKI CASEY C Officer	Sale at price 35.21 per share.	Direct	387,313	02 Jan 2019	11,000
KOPCZYNSKI CASEY C Officer	Sale at price 39.79 - 40.55 per share.	Direct	437,894	03 Dec 2018	11,000
KOPCZYNSKI CASEY C Officer	Sale at price 52.99 - 54.22 per share.	Direct	592,521	01 Nov 2018	11,000
KOPCZYNSKI CASEY C Officer	Sale at price 60.43 - 61.34 per share.	Direct	666,204	01 Oct 2018	11,000
RUBINO RICHARD J Chief Financial Officer	Sale at price 60.18 - 61.01 per share.	Direct	4,011,831	27 Sep 2018	66,605
RUBINO RICHARD J Chief Financial Officer	Sale at price 60.00 per share.	Direct	120	14 Sep 2018	2
RUBINO RICHARD J Chief Financial Officer	Sale at price 60.17 per share.	Direct	2,076,608	13 Sep 2018	34,512
KOPCZYNSKI CASEY C Officer	Sale at price 60.00 - 61.00 per share.	Direct	661,024	04 Sep 2018	11,000
MITRO THOMAS A President	Sale at price 60.27 - 61.01 per share.	Direct	11,451,006	27 Aug 2018	190,000
MITRO THOMAS A President	Conversion of Exercise of derivative security at price 3.15 per share.	Direct	598,500	27 Aug 2018	190,000
KOPCZYNSKI CASEY C Officer	Sale at price 68.00 - 68.69 per share.	Direct	751,298	01 Aug 2018	11,000
KOPCZYNSKI CASEY C Officer	Sale at price 66.15 - 67.09 per share.	Direct	730,064	02 Jul 2018	11,000
ANIDO VICENTE JR., PH.D. Chief Executive Officer	Sale at price 61.90 - 62.92 per share.	Direct	3,100,295	11 Jun 2018	50,000
ANIDO VICENTE JR., PH.D. Chief Executive Officer	Conversion of Exercise of derivative security at price 3.15 per share.	Direct	157,500	11 Jun 2018	50,000
ANIDO VICENTE JR., PH.D. Chief Executive Officer	Sale at price 60.44 - 64.52 per share.	Direct	9,342,381	08 Jun 2018	150,000
ANIDO VICENTE JR., PH.D. Chief Executive Officer	Conversion of Exercise of derivative security at price 2.90 - 3.15 per share.	Direct	441,535	08 Jun 2018	150,000
GOLDBERG MURRAY A Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	07 Jun 2018	1,750
MCGRAW BENJAMIN F III Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	07 Jun 2018	1,750
CAGLE GERALD D Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	07 Jun 2018	1,750
MCHUGH JULIE H Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	07 Jun 2018	1,750
CROARKIN RICHARD Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	07 Jun 2018	1,750
DU TOIT MICHAEL Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	07 Jun 2018	1,750
KOPCZYNSKI CASEY C Officer	Sale at price 58.57 - 59.21 per share.	Direct	646,237	06 Jun 2018	11,000
KOPCZYNSKI CASEY C Officer	Sale at price 50.15 per share.	Direct	135,806	29 May 2018	2,708
KOPCZYNSKI CASEY C Officer	Conversion of Exercise of derivative security at price 5.00 per share.	Direct	15,000	24 May 2018	3,000
ANIDO VICENTE JR., PH.D. Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	12 Apr 2018	21,448
MITRO THOMAS A President	Stock Award(Grant) at price 0.00 per share.	Direct	0	12 Apr 2018	9,040
RUBINO RICHARD J Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	12 Apr 2018	9,040
LAROCCA JOHN General Counsel	Stock Award(Grant) at price 0.00 per share.	Direct	0	19 Feb 2018	18,000
KOPCZYNSKI CASEY C Officer	Conversion of Exercise of derivative security at price 0.40 per share.	Direct	1,284	09 Feb 2018	3,251
ANIDO VICENTE JR., PH.D. Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	08 Feb 2018	25,413
MITRO THOMAS A President	Stock Award(Grant) at price 0.00 per share.	Direct	0	08 Feb 2018	12,778
RUBINO RICHARD J Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	08 Feb 2018	10,667
KOPCZYNSKI CASEY C Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	08 Feb 2018	8,000
GOLDBERG MURRAY A Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	08 Jun 2017	1,150
MCGRAW BENJAMIN F III Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	08 Jun 2017	1,150
CAGLE GERALD D Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	08 Jun 2017	1,150
MCHUGH JULIE H Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	08 Jun 2017	1,150
CROARKIN RICHARD Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	08 Jun 2017	1,150
DU TOIT MICHAEL Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	08 Jun 2017	1,150
FORESITE CAPITAL MANAGEMENT II, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Sale at price 55.95 per share.	Indirect	1,119,000	26 May 2017	20,000
DUYK GEOFFREY M Director	Sale at price 46.46 - 46.81 per share.	Direct	1,939,497	15 Feb 2017	41,591
DUYK GEOFFREY M Director	Conversion of Exercise of derivative security at price 3.15 - 32.30 per share.	Direct	778,132	14 Feb 2017	58,167
FORESITE CAPITAL MANAGEMENT II, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Sale at price 40.34 per share.	Indirect	2,016,995	06 Oct 2016	50,000
FORESITE CAPITAL MANAGEMENT II, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Sale at price 40.34 per share.	Indirect	2,016,995	06 Oct 2016	50,000
GOLDBERG MURRAY A Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	08 Jun 2016	1,700
MCGRAW BENJAMIN F III Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	08 Jun 2016	1,700
DUYK GEOFFREY M Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	08 Jun 2016	1,700
CAGLE GERALD D Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	08 Jun 2016	1,700
MCHUGH JULIE H Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	08 Jun 2016	1,700
CROARKIN RICHARD Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	08 Jun 2016	1,700
DU TOIT MICHAEL Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	08 Jun 2016	1,700
ANIDO VICENTE JR., PH.D. Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	24 Feb 2016	25,085
MITRO THOMAS A President	Stock Award(Grant) at price 0.00 per share.	Direct	0	24 Feb 2016	11,875
RUBINO RICHARD J Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	24 Feb 2016	10,000
KOPCZYNSKI CASEY C Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	24 Feb 2016	9,000
GRYSKA DAVID W Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	10 Apr 2015	1,700
GOLDBERG MURRAY A Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	10 Apr 2015	1,700
MCGRAW BENJAMIN F III Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	10 Apr 2015	1,700
DUYK GEOFFREY M Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	10 Apr 2015	1,700
CAGLE GERALD D Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	10 Apr 2015	1,700
MEHRA ANAND Director	Stock Award(Grant) at price 0.00 per share.	Direct	0	10 Apr 2015	1,700
ANIDO VICENTE JR., PH.D. Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	25 Feb 2015	22,188
RUBINO RICHARD J Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	25 Feb 2015	9,063
CLARUS LIFESCIENCES II L P Beneficial Owner of more than 10% of a Class of Security	Sale at price 31.11 per share.	Indirect	5,444,250	08 Jan 2015	175,000
CLARUS LIFESCIENCES II L P Beneficial Owner of more than 10% of a Class of Security	Sale at price 30.67 - 31.11 per share.	Indirect	728,913	05 Jan 2015	23,620
CLARUS LIFESCIENCES II L P Beneficial Owner of more than 10% of a Class of Security	Sale at price 30.03 - 30.05 per share.	Indirect	2,425,632	29 Dec 2014	80,724
CLARUS LIFESCIENCES II L P Beneficial Owner of more than 10% of a Class of Security	Sale at price 30.00 - 30.36 per share.	Indirect	1,508,919	23 Dec 2014	49,704
TPG GROUP HOLDINGS SBS ADVISORS INC Unknown	Sale at price 25.97 per share.	Indirect	33,761,000	25 Nov 2014	1,300,000
MEHRA ANAND Director	Sale at price 26.00 per share.	Indirect	20,800,000	25 Nov 2014	800,000
TPG GROUP HOLDINGS SBS ADVISORS, INC. Unknown	Sale at price 25.97 per share.	Indirect	33,761,000	25 Nov 2014	1,300,000
SOFINNOVA VENTURE PARTNERS VII L P Beneficial Owner of more than 10% of a Class of Security	Sale at price 24.00 - 25.81 per share.	Indirect	24,208,330	10 Jul 2014	1,008,022
TPG GROUP HOLDINGS SBS ADVISORS INC Beneficial Owner of more than 10% of a Class of Security	Sale at price 25.05 - 25.28 per share.	Indirect	25,165,000	10 Jul 2014	1,000,000
MEHRA ANAND Beneficial Owner of more than 10% of a Class of Security	Sale at price 24.00 - 25.81 per share.	Indirect	24,208,330	10 Jul 2014	1,008,022
TPG GROUP HOLDINGS SBS ADVISORS, INC. Beneficial Owner of more than 10% of a Class of Security	Sale at price 25.05 - 25.28 per share.	Indirect	25,165,000	10 Jul 2014	1,000,000
ACP IV L P Beneficial Owner of more than 10% of a Class of Security	Sale at price 16.00 per share.	Indirect	4,800,000	22 May 2014	300,000
MEHRA ANAND Director and Beneficial Owner of more than 10% of a Class of Security	Sale at price 16.00 per share.	Indirect	5,182,912	22 May 2014	323,932
TPG GROUP HOLDINGS SBS ADVISORS, INC. Beneficial Owner of more than 10% of a Class of Security		Indirect		30 Oct 2013	3,595,314
CLARUS LIFESCIENCES II L P Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 0.00 per share.	Indirect	0	25 Oct 2013	3,147,492

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Insider transactions

Insider transactions reported - last two years

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