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Deinove SA (ALDEI.PA)

Paris - Paris Delayed price. Currency in EUR
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0.6160-0.0240 (-3.75%)
At close: 5:28PM CEST
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Previous close0.6400
Open0.6130
Bid0.0000 x 0
Ask0.0000 x 0
Day's range0.6110 - 0.6290
52-week range0.4600 - 1.2500
Volume78,980
Avg. volume155,619
Market cap17.077M
Beta (5Y monthly)0.85
PE ratio (TTM)N/A
EPS (TTM)-0.4400
Earnings dateN/A
Forward dividend & yieldN/A (N/A)
Ex-dividend dateN/A
1y target est3.90
  • Globe Newswire

    DEINOVE- Second convening to a Combined General Meeting on June 21, 2021

    DEINOVE- Second convening to a Combined General Meeting on June 21, 2021 DEINOVE (Euronext Growth Paris: ALDEI), a French biotech company, pioneer in the exploration and exploitation of bacterial biodiversity to address the urgent, global challenge of antibiotic resistance, informs its shareholders that the combined Annual General Meeting (AGM) held on May 27, 2021 was unable to deliberate, as the required quorum was not reached, and that a new AGM will be held on June 21, 2021 at 2 pm CEST, in the premises of Fieldfisher, 48 rue Cambon, 75001 Paris, to deliberate on the same agenda. DEINOVE’s combined AGM was held yesterday. The shareholders who were present, duly represented or who had voted remotely owned collectively 2,724,731 actions, representing 9.84 % of the share capital. Therefore, in the absence of the quorum required to rule on the ordinary and extraordinary resolutions, none of the proposed resolutions as listed in the meeting notice published in the French official legal bulletin Bulletin des Annonces Légales Obligatoires (BALO) no 48, dated April 21, 2021, has been put to the vote of the shareholders. The shareholders are hereby invited to a second AGM held on Monday, June 21, 2021 at 2 pm CEST in the premises of Fieldfisher, 48 rue Cambon, 75001 Paris, to deliberate on the same agenda. A second convening notice will be published on June 2, 2021 in the BALO and in a legal newspaper. All the documents regarding this AGM will be available on the Company’s website as from June 2, 2021: https://www.deinove.com/en/investor-room/documentation-center/general-shareholders-meeting-preparatory-documents As a precaution, DEINOVE’s shareholders are encouraged to anticipate their votes and to favor the use of postal votes or proxy votes to take part in the AGM. The shareholders’ vote for the first AGM remains valid and counted for the second AGM. The shareholders are strongly encouraged to vote in advance via email. Forms for postal vote or proxy vote: Available on request to the Company (assemblee-generale@deinove.com)Downloadable on the Company’s website: https://www.deinove.com/en/investor-room/documentation-center/general-shareholders-meeting-preparatory-documents Deadline for considering voting forms: Friday, June 28, 2021 at 0:00 AM CEST. Sending methods: By post: DEINOVE – A l’attention de Monsieur Mario ALCARAZ, 1682, rue de la Valsière - CAP SIGMA, ZAC EUROMEDECINE II - 34790 GrabelsBy email: assemblee-generale@deinove.com Supporting documents: Registered shareholders: noneBearer shareholders: certificate of account registration delivered by their account-holding institution. Our investor relations team is available for any additional question: assemblee-generale@deinove.com ABOUT DEINOVE DEINOVE is a French biotechnology company pioneering the exploration of a new domain of life, unexplored at 99.9%: the “microbial dark matter”. By revealing the metabolic potential of rare bacteria or still classified as uncultivable, it tackles a global health and economic challenge: antimicrobial resistance. The new therapies discovered and developed by DEINOVE target superbugs (microbes that have become resistant to one or more antimicrobials) that cause life-threatening infections which are now spreading at high speed. This breakthrough approach gave rise to one of the world’s first specialized micro-biotechnology platforms and a unique collection of nearly 10,000 rare strains and thousands of bacterial extracts. Today, DEINOVE is conducting several development programs, of which its first antibiotic candidate is currently evaluated in a Phase II clinical trial in severe Clostridioides difficile infections, one of the world’s first emergencies. The Company has also developed new bacterial micro-factories that address the other issue in the race against antimicrobial resistance: the industrial production of these rare and low concentrated compounds with often too complex chemical structures to be generated by chemical synthesis. Located at the heart of the Euromedecine park in Montpellier, DEINOVE has been listed on EURONEXT GROWTH® (ALDEI - code ISIN FR0010879056) since 2010. The Company has over 50 employees and relies on a network of world-class academic, technological, industrial and institutional partners. CONTACTS InvestorsMario AlcarazChief Financial and Administrative Officer +33 (0)4 48 19 01 00ir@deinove.comMediaATCG Partners – Marie PUVIEUX+33 (0)9 81 87 46 72 / +33 (0)6 10 54 36 72communication@deinove.com Attachment PR in English

  • Globe Newswire

    DEINOVE, ESPCI Paris and INRAE awarded grant following the call for proposals of the French “Antibiotic resistance” Priority Research Program

    DEINOVE, ESPCI Paris and INRAE awarded grant following the call for proposals of the French“Antibiotic resistance” Priority Research Program The Microflu4AMR project, based on microfluidic technology and the exploitation of soil microbial diversity, will enable the search and selection of active molecules to meet the challenges of antibiotic resistanceThe French ANR will fund the project's academic partners with a €2M grant DEINOVE (Euronext Growth Paris: ALDEI), a French biotech company pioneering the exploration and exploitation of bacterial biodiversity to address the urgent and global challenge of antimicrobial resistance, announces that it has been selected with ESPCI Paris1 and INRAE2 for a project financed by the French National Agency for Research (ANR) through a 2 million-euros grant, following an extremely competitive selection process. The Microflu4AMR project is one of the 11 winners selected - out of over 130 applications - within the national priority research program (PRP) on antibiotic resistance by an international jury chaired by Professors Herman Goossens, Benedikt Huttner, Rafael Canton and comprising 25 world-class experts3. Microflu4AMR is complementary to DEINOVE’s Deinodrop and Boost-ID projects, the latter of which was recently selected as part of the France Relance call for proposals (where 10% of industrial projects were selected)4. Boost-ID and Microflu4AMR were submitted under separate calls for proposals, with independent, demanding, and highly selective evaluation processes. The evaluations reached the same conclusion: the microfluidic technology developed by DEINOVE is considered by the scientific and industrial community as a major asset for the screening and identification of new therapeutic solutions from bacterial biodiversity. Antibiotic resistance has become a major public health emergency that is now mobilizing the entire international community5, and of course France. Discovery of new antibiotics is therefore crucial to address this urgent challenge. In this regard, the Microflu4AMR project will actually: Increase knowledge on soil microbial communities allowing the analysis and selection of soil samples based on their potential for the discovery of new active antibiotic molecules,Develop and implement a high-throughput system at the single-cell level for the sorting of antibiotic-producing bacteria from the aforementioned pre-selected soil samples. “We are delighted to have been selected as part of the highly demanding Antibiotic resistance program and to be able to pursue our technological developments in microfluidics with the prestigious teams at ESPCI Paris and INRAE”, said Alexis Rideau, CEO of DEINOVE. “Combined with DEINOVE’s cutting-edge expertise in synthetic biology, microfluidics open up tremendous opportunities for screening at an unprecedented rate (with a throughput of up to one million bacteria tested per hour), whilst drastically reducing costs (reagents) and environmental impact (plastics)”. ABOUT DEINOVE DEINOVE is a French biotechnology company pioneering the exploration of a new domain of life, unexplored at 99.9%: the “microbial dark matter”. By revealing the metabolic potential of rare bacteria or still classified as uncultivable, it tackles a global health and economic challenge: antimicrobial resistance. The new therapies discovered and developed by DEINOVE target superbugs (microbes that have become resistant to one or more antimicrobials) that cause life-threatening infections which are now spreading at high speed. This breakthrough approach gave rise to one of the world’s first specialized micro-biotechnology platforms and a unique collection of nearly 10,000 rare strains and thousands of bacterial extracts. Today, DEINOVE is conducting several development programs, of which its first antibiotic candidate is currently evaluated in a Phase II clinical trial in severe Clostridioides difficile infections, one of the world’s first emergencies. The Company has also developed new bacterial micro-factories that address the other issue in the race against antimicrobial resistance: the industrial production of these rare and low concentrated compounds with often too complex chemical structures to be generated by chemical synthesis.Located at the heart of the Euromedecine park in Montpellier, DEINOVE has been listed on EURONEXT GROWTH® (ALDEI – code ISIN FR0010879056) since 2010. The Company has over 50 employees and relies on a network of world-class academic, technological, industrial and institutional partners. ABOUT THE ANTIOBIOTICS RESISTANCE CALL FOR PROJECTS: “UNDERSTAND, INNOVATE, ACT” Launched in January 2020 for a 10-year6 period, the priority research program (PRP) on antibiotic resistance has the following objectives: to set up an ambitious research program bringing together all French forces, to propose new public health strategies and control measures aiming to reduce and optimize the use of antibiotics in human and veterinary medicine and ultimately reverse the resistance curve, in line with international policies. The Antibiotic resistance “understand, innovate, act” call for proposals7 launched under the guidance of ANR is the operational component of this PRP. It aims to support “very ambitious, structuring, long-term (3 to 6 years) research projects favoring interdisciplinarity and contributing to the emergence of synergies between different types of research (fundamental, environmental, clinical, translational), with the goal of stimulating and supporting the emergence of diagnostic, preventive and therapeutic innovations, and ultimately leading to a better use of antibiotics”. CONTACTS InvestorsMario AlcarazChief Financial and Administrative Officer +33 (0)4 48 19 01 00ir@deinove.comMediaATCG Partners – Marie PUVIEUX+33 (0)9 81 87 46 72 / +33 (0)6 10 54 36 72communication@deinove.com 1 Advanced School of Industrial Physics and Chemistry in Paris2 National Research Institute for agriculture, food and nutrition, and the environment3 https://anr.fr/fileadmin/aap/2020/selection/ia-aap-ppr-amr-2020-jury.pdf 4 See press release March 10, 20215 Carlet Report https://solidarites-sante.gouv.fr/IMG/pdf/rapport_antibiotiques.pdf 6 https://solidarites-sante.gouv.fr/actualites/presse/communiques-de-presse/article/coup-d-envoi-du-programme-prioritaire-de-recherche-sur-l-antibioresistance-429001 7 https://anr.fr/fr/detail/call/antibioresistance-comprendre-innover-agir-appel-a-projets-2020/ Attachment PR in English

  • Globe Newswire

    DEINOVE presents its financial results and the advancement of its programs for 2020

    DEINOVE presents its financial results and the advancement of its programs for 2020 ·Phase II of the antibiotic candidate DNV3837 ongoing – end of the first part of the trial (DSMB) expected mid-2021 ·Signature of an Evaluation and Technology Development license with DSM on a non-therapeutic active substance ·Management evolution: two experienced profiles have joined DEINOVE to strengthen the business development and strategic partnerships activities ·Group net income 2020 of -€7.3M compared to -€10.2M in 2019, mainly thanks to lower operating expenses • Restructuring of operations with a 30% decrease in operating expenses (€9.0M vs. €12.8M in 2019), still 80% dedicated to R&D ·Group cash position: • Balance of +€2.9M at December 31, 2020, compared to +€1.1M at 31 December 31, 2019 • On January 20, 2021, the 5th tranche of OCA was subscribed by the ESGO Fund, for an amount of €3M DEINOVE (Euronext Growth Paris: ALDEI), a French biotech company, pioneer in the exploration and exploitation of bacterial biodiversity to address the urgent, global challenge of antibiotic resistance, announces that its Board of Directors has approved the consolidated financial statements for the year 2020. “The Board of Directors and I renewed our confidence in Alexis RIDEAU, by appointing him CEO of DEINOVE at the beginning of 2021. The transformations he has led with the management team have already streamlined operational expenses and will position DEINOVE at the forefront of the exploration and exploitation of microbial dark matter, to become a major player in the generation of new antimicrobials”, says Dr. Charles WOLER, Chairman of DEINOVE’s Board of Directors. “We were delighted to announce that DEINOVE has received support from the French government as part of the “France Relance” plan, to set up a platform for screening bacteria at very high throughput based on breakthrough technology, droplet-based microfluidics. The goal is to be operational by the end of 2021. This new technology will dramatically increase the platform’s current performance, while reducing its costs.” “We have strengthened our team with the arrival of a new CFO, Mario ALCARAZ, who has successfully restructured the operational expenses necessary to sustain the platform. At the beginning of 2021, the Business Development team was strengthened with the arrival of Hervé ANSANAY, as Director, and Corentin CHABOUD, to the new position of Grant Officer. Both of these hires are strategic to intensify the establishment of new partnerships, such as the one signed with the Dutch company DSM, as well as to access non-dilutive funding to support the development of new antimicrobials”, adds Alexis RIDEAU, CEO of DEINOVE. *** DEINOVE will organize a webinar for its shareholders on May 4, 2020 at 5:30 pm to make an update on its activity and perspective and in order to prepare its upcoming Annual General Meeting (to be held on May 27, probably in closed session due to the pandemic) To sign up for the May 4 webinar (to be held in French) please follow this link *** SUMMARY OF CONSOLIDATED FINANCIAL DATA The DEINOVE Group’s consolidated financial statements as of December 31, 2020 were certified by the Group’s Statutory Auditors, the firm PwC (PricewaterhouseCoopers). PROFIT AND LOSS ACCOUNT (in thousands of euros)31/12/2031/12/19Operating revenues 836637Of which operating grants392397Operating costs8,96112,838Of which Research & Development costs7,16810,459Of which Administrative and General costs1,7922,379OPERATING PROFIT/LOSS (8,125)(12,201)PROFIT/LOSS(21)(34)PROFIT/LOSS FROM NON-RECURRING ACTIVITIES365Income tax and deferred taxes(1,354)(2,433)Goodwill amortization511511Results from equity affiliates (MEQ)--CONSOLIDATED GROUP PROFIT/LOSS (7,300)(10,247) (in thousands of euros)(7,300)(10,247)Term deposit--Provision for impairment of marketable securities--Cash on hand2,8991,095ICNE & bank overdrafts- -CASH & CASH EQUIVALENTS2,8991,095 OPERATIONAL PROGRESS DURING THE PERIOD AND POST-CLOSING Phase II testing the antibiotic candidate DNV3837 in severe Clostrioides difficile infections This clinical trial aims to evaluate the efficacy and the pharmacokinetics of DNV3837 in patients with Clostridioides difficile gastrointestinal infection (CDI). This trial is being conducted in the United States, according to a sequential protocol: The first step aims to treat a cohort of 10 patients with moderate to severe CDI with DNV3837. At the end of this phase, the DSMB1 will review the interim results and issue an opinion on the benefit-risk balance of the treatment.The second step aims to treat 30 patients with severe CDI in a randomized open-label trial testing DNV3837 (2/3 of patients) against an approved standard treatment2 (1/3 of patients) for comparison. In November 2020, at the annual conference of the C Diff Foundation, in the “Research in Progress” session, DEINOVE presented the phase I results, the protocol of the ongoing multicentric phase II in the United States, including clinical centers, the team in France and across the Atlantic, as well as the main advantages of DNV3837: its intravenous administration, precise targeting at the site of infection, its ability to eliminate Clostridioides difficile bacteria while having a limited impact on the intestinal microbiota. Patient enrollment in this phase II trial continues, despite the disruption caused by the COVID-19 pandemic. DEINOVE is a winner of the “France Relance” plan The Boost-ID project (Bacteria Optimum Output Screening Tool for treating Infectious Diseases) is one of 105 projects selected by the French government, out of nearly 1,000 presented, as part of the call for resilience projects within the framework of the “France Relance” plan, a recognition of its strategic positioning. Boost-ID is an accelerator in the identification of antimicrobials and molecules of natural origin with high added value. It consists of setting up a platform for screening bacteria at very high throughput based on breakthrough technology: droplet-based microfluidics. With a major gain in efficiency upstream of the process, Boost-ID will accelerate the development of new antimicrobials and molecules of natural origin with high added value. It is one of six projects in the strategic health sector selected by the French government in the Occitania region. DEINOVE signs an evaluation and technology development license with DSM In November 2020, DEINOVE announced the signing of an evaluation and technology development license with DSM, a global science-based company in Nutrition, Health and Sustainable Living. Under the agreement, DSM will evaluate the potential of a microbial strain from DEINOVE as a feed additive; selected and characterized during the Color-2B program. The evaluation and technology development program is undertaken and supervised by DSM. For the exclusive purpose of the performance of the collaboration activities, DSM is granted a temporary exclusive license to use DEINOVE’s proprietary strain, as well as the background intellectual property related to the strain and required for the collaboration activities. In consideration of these provisions, DEINOVE will receive an upfront payment and milestone payments during program execution (undisclosed amount). Upon DSM’s decision that the collaboration activities are successful, DEINOVE and DSM will pursue negotiations for a commercial license agreement. CORPORATE BOARD OF DIRECTORS The Ordinary and Extraordinary Shareholders’ Meeting of June 16, 2020, renewed, for a period of three years, the mandates of Anne ABRIAT, Charles WOLER and Hervé BRAILLY, which had expired. It also ratified the appointment of Emmanuel PETIOT as Administrator, made on a provisional basis by the Board of Directors at its meeting of December 3, 2019. EXECUTIVE COMMITTEE Alexis RIDEAU, Deputy Chief Executive Officer of DEINOVE since May 2020, was appointed Chief Executive Officer of the Company in January 2021. Prior to joining DEINOVE, Alexis RIDEAU was in charge of developing industrial relations and coordinating the strategic partnership team at BIOASTER (Lyon/Paris), a Technology Research Institute in applied microbiology, which specializes in the design and use of technology innovations in the field of microbiology, to accelerate the development of medical and nutritional industrial solutions for animal and human health. In appointing him as CEO, the Board of Directors recognized his achievements, vision and action plan to make DEINOVE a major actor in the race against antimicrobial resistance. As of July 2020, Mario ALCARAZ joined DEINOVE as Chief Financial and Administrative Officer, also in charge of investor relations and financial communication. An experienced financial director, mastering at the same time the financial, legal, accounting and strategic aspects of the function, he is a key asset in ensuring DEINOVE’s economic performance. Since his arrival, he has successfully carried out the necessary restructuring of operational expenses to ensure the platform’s sustainability. Post period-end, Hervé ANSANAY, PhD, former Director of Technology Transfer and Business Development at SATT AxLR in Montpellier, was appointed Director of Business Development. He brings 20 years’ experience in supporting innovative companies and technology transfer. From 2013 to 2015, he was Business Developer at SATT Nord. After his PhD and post-doc in biochemistry and molecular biology, Hervé was R&D project manager for over 10 years at Cisbio Bioassays, in charge of market-driven developments. Corentin CHABOUD, previously in charge of European affairs and competitive funding at IRT BIOASTER, became Grant Officer at DEINOVE. These two hires, in January 2021, will intensify the setting up of remunerative strategic partnerships and access to non-dilutive funding, to support the development of therapeutic solutions in the field of next-generation antimicrobials. FINANCIAL RESULTS FOR THE PERIOD 2020 OPERATING REVENUE The Group recorded €836K in operating revenue for the period (compared to €637K in 2019), including €392K of the grant paid by Bpifrance corresponding to the completion of the second key milestone of the AGIR program (€397K in 2019, for the first key milestone of the same program) and, on the other hand, €323K of revenue (compared to €163K in 2019) in the framework of collaborative research agreements with industrial partners in non-therapeutic fields. During the fiscal year 2020, the Group’s operating expenses reached €9.0M, of which 80% was spent on R&D activities. The net change in operating expenses between 2019 and 2020 amounts to -€3.8M (-30%). Subcontracting and external research expenses decreased significantly (-72%), due to the internalization of the sequencing activity and a decrease in costs related to analyses. Personnel expenses also decreased, in line with the evolution of the workforce: 57.0 average full-time equivalents (FTE) in 2020 compared to 60.0 in 2019. NET INCOME The consolidated net loss for the period amounts to €7.3M, negligibly impacted by exceptional items (positive exceptional result of €3K). The negative financial result of -€21K is mainly due to financial expenses related to the pre-financing of the Research Tax Credit (-€12K) and interest expenses on loans (-€6K). Income tax comprises almost exclusively the Research Tax Credit. The Group’s receivable for the fiscal year 2020 has been estimated at €1,354K (compared to €2,491K in 2019). NET RESULT In 2020, 6,494,493 new shares were issued, including 5,994,492 shares under the convertible bond agreement3. At its meeting on November 3, 2020, the Board of Directors, implementing an authorization granted by the Extraordinary Shareholders’ Meeting of December 11, 2019, decided to reduce the share capital by reducing the nominal value of the ordinary shares comprising the capital. The nominal value is thus reduced by 0.40 to 0.02 euro per share. This capital reduction was carried out by offsetting losses carried forward. The 24,090,739 shares with a nominal value of 0.02 euro making up the capital as of December 31, 2020, are broken down as follows: Year ended December 31, 2020 – non-diluted basis ShareholdersNumber of shares% of holdingVoting rights%Funds managed by Truffle Capital1,385,6375.75%2,553,3259.96%Funds managed by TVM Capital1,557,4146.46%1,557,4146.07%Scientific founders20,0000.08%40,0000.16%Free float21,127,68887.70%21,493,74183.81%TOTAL24,090,739100.00%25,644,480100.00% ABOUT DEINOVE DEINOVE is a French biotechnology company pioneering the exploration of a new domain of life, unexplored at 99.9%: the “microbial dark matter”. By revealing the metabolic potential of rare bacteria or still classified as uncultivable, it tackles a global health and economic challenge: antimicrobial resistance. The new therapies discovered and developed by DEINOVE target superbugs (microbes that have become resistant to one or more antimicrobials) that cause life-threatening infections which are now spreading at high speed. This breakthrough approach gave rise to one of the world’s first specialized micro-biotechnology platforms and a unique collection of nearly 10,000 rare strains and thousands of bacterial extracts. Today, DEINOVE is conducting several development programs, of which its first antibiotic candidate is currently evaluated in a Phase II clinical trial in severe Clostridioides difficile infections, one of the world’s first emergencies. The Company has also developed new bacterial micro-factories that address the other issue in the race against antimicrobial resistance: the industrial production of these rare and low concentrated compounds with often too complex chemical structures to be generated by chemical synthesis. Located at the heart of the Euromedecine park in Montpellier, DEINOVE has been listed on EURONEXT GROWTH® (ALDEI - code ISIN FR0010879056) since 2010. The Company has over 50 employees and relies on a network of world-class academic, technological, industrial and institutional partners. CONTACTS Investors Mario Alcaraz Chief Financial and Administrative Officer +33 (0)4 48 19 01 00 ir@deinove.com Media ATCG Partners – Marie PUVIEUX +33 (0)9 81 87 46 72 / +33 (0)6 10 54 36 72 communication@deinove.com 1 DSMB: Data Safety Monitoring Board (Data Monitoring and Tracking Committee). An independent panel of experts to review the data generated and make recommendations on patient safety, validity and relevance of the trial. 2 Standard therapies approved in the United States for the treatment of CDI include vancomycin, fidaxomicin, and metronidazole (all three antibiotics). The choice will be at the discretion of the investigating physicians. 3 Press release issued April 3, 2020, June 17, 2020 and December 3, 2020 Attachment PR in English