Insider	Transaction	Type	Value	Date	Shares
THOMPSON JOHN CRAIG Chief Executive Officer	Purchase at price 1.32 per share.	Direct	11,286	20 Sept 2017	8,550
TRUEX PAUL F Director	Purchase at price 1.34 per share.	Indirect	6,700	07 Sept 2017	5,000
THOMPSON JOHN CRAIG Chief Executive Officer	Conversion of Exercise of derivative security at price 1.43 per share.	Direct	14,893	07 Sept 2017	10,400
THOMPSON JOHN CRAIG Chief Executive Officer	Purchase at price 1.43 per share.	Direct	14,893	07 Sept 2017	10,400
THOMPSON JOHN CRAIG Chief Executive Officer	Stock Award(Grant) at price 0.55 per share.	Direct	3,954	11 Jan 2017	7,190
OLSON CHARLES V Chief Technology Officer	Stock Award(Grant) at price 0.55 - 2.63 per share.	Direct	8,977	11 Jan 2017	9,556
TRUEX PAUL F Chief Executive Officer	Stock Gift at price 0.00 per share.	Direct	0	20 Sept 2016	5,008
TRUEX PAUL F Chief Executive Officer	Conversion of Exercise of derivative security at price 2.08 per share.	Direct	10,417	20 Sept 2016	5,008
MUELLER BRIAN R Director	Conversion of Exercise of derivative security at price 2.89 per share.	Direct	28,900	23 Dec 2015	10,000
HISLOP COLIN Officer	Sale at price 5.38 per share.	Direct	26,900	11 Nov 2015	5,000
ODINK DEBRA A Chief Technology Officer	Sale at price 6.15 per share.	Direct	7,411	12 Oct 2015	1,205
TRUEX PAUL F Chief Executive Officer	Stock Award(Grant) at price 8.62 per share.	Direct	107,750	30 Jun 2015	12,500
TRUEX PAUL F Chief Executive Officer	Stock Gift at price 0.00 per share.	Indirect	0	30 Jun 2015	12,500
DICKINSON-EASON KLARA A Officer	Stock Award(Grant) at price 8.62 per share.	Direct	107,750	30 Jun 2015	12,500
LIU MAY Officer	Stock Award(Grant) at price 8.62 per share.	Direct	107,750	30 Jun 2015	12,500
TRUEX PAUL F Chief Executive Officer	Stock Gift at price 0.00 per share.	Direct	0	31 Dec 2014	12,500
ODINK DEBRA A Chief Technology Officer	Stock Gift at price 0.00 per share.	Direct	0	30 Dec 2014	1,364
TRUEX PAUL F Chief Executive Officer	Stock Gift at price 0.00 per share.	Indirect	0	30 Jun 2014	16,500
TRUEX PAUL F Chief Executive Officer	Conversion of Exercise of derivative security at price 2.08 per share.	Direct	4,160	30 Jun 2014	2,000
TRUEX PAUL F Chief Executive Officer	Stock Award(Grant) at price 0.00 - 3.30 per share.	Indirect	20,625	25 Mar 2014	10,114
TRUEX PAUL F Chief Executive Officer	Stock Award(Grant) at price 0.00 - 3.30 per share.	Indirect	20,625	25 Mar 2014	10,114
ODINK DEBRA A Chief Technology Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	25 Mar 2014	3,864
HISLOP COLIN Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	25 Mar 2014	3,864
LIU MAY Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	25 Mar 2014	3,625
THOMPSON DAVID E Director	Purchase at price 0.53 per share.	Indirect	53,000	24 Jun 2013	100,000
DZIURZYNSKI BOGDAN Director	Purchase at price 0.59 per share.	Direct	11,800	31 May 2013	20,000
TRUEX PAUL F Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	25 Mar 2013	135,644
LOWE CHRISTOPHER P Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	25 Mar 2013	67,579
ODINK DEBRA A Chief Technology Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	25 Mar 2013	49,519
HISLOP COLIN Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	25 Mar 2013	59,132
ORBIMED ADVISORS, L.L.C. Unknown	Purchase at price 0.66 per share.	Indirect	3,762,000	30 Jan 2013	5,700,000
ORBIMED ADVISORS, L.L.C. Unknown	Purchase at price 0.65 per share.	Indirect	1,142,481	25 Jan 2013	1,762,000
ODINK DEBRA A Chief Technology Officer	Stock Gift at price 0.00 per share.	Direct	0	10 Jan 2013	4,009
TRUEX PAUL F Chief Executive Officer	Stock Gift at price 0.00 per share.	Direct	0	07 Jan 2013	66,412
HENNEY CHRISTOPHER S Director	Purchase at price 0.75 per share.	Indirect	149,860	29 Jun 2012	200,000
ORBIMED ADVISORS, L.L.C. Unknown	Sale at price 0.73 per share.	Indirect	942,071	29 Jun 2012	1,283,300
TRUEX PAUL F Chief Executive Officer	Purchase at price 0.76 per share.	Indirect	15,200	29 Jun 2012	20,000
ORBIMED ADVISORS, L.L.C. Unknown	Sale at price 2.40 - 2.90 per share.	Indirect	3,837,082	22 Mar 2012	1,548,500
ODINK DEBRA A Chief Technology Officer	Sale at price 6.57 per share.	Direct	13,140	01 Mar 2012	2,000
HISLOP COLIN Officer	Conversion of Exercise of derivative security at price 0.26 per share.	Direct	10,400	23 Feb 2012	40,000
TRUEX PAUL F Chief Executive Officer	Sale at price 7.84 per share.	Indirect	117,600	15 Feb 2012	15,000
TRUEX PAUL F Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	06 Feb 2012	37,984
LOWE CHRISTOPHER P Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	06 Feb 2012	18,845
ODINK DEBRA A Chief Technology Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	06 Feb 2012	7,418
HISLOP COLIN Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	06 Feb 2012	9,923
KILFOIL GEORGINA H Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	06 Feb 2012	5,243
HISLOP COLIN Officer	Sale at price 8.20 per share.	Direct	246,000	03 Feb 2012	30,000
LOWE CHRISTOPHER P Chairman of the Board	Sale at price 7.66 per share.	Direct	114,900	01 Feb 2012	15,000
ODINK DEBRA A Chief Technology Officer	Sale at price 7.67 per share.	Direct	15,340	01 Feb 2012	2,000
TRUEX PAUL F Chief Executive Officer	Conversion of Exercise of derivative security at price 0.26 per share.	Indirect	5,200	31 Jan 2012	20,000
HEALY JAMES I Director	Conversion of Exercise of derivative security at price 4.19 per share.	Direct	50,280	27 Jan 2012	12,000
TRUEX PAUL F Chief Executive Officer	Stock Gift at price 0.00 per share.	Indirect	0	27 Jan 2012	7,000
TRUEX PAUL F Chief Executive Officer	Sale at price 6.75 per share.	Indirect	101,250	17 Jan 2012	15,000
ODINK DEBRA A Chief Technology Officer	Sale at price 6.51 per share.	Direct	5,205	10 Jan 2012	800
ODINK DEBRA A Chief Technology Officer	Sale at price 6.50 per share.	Direct	7,800	06 Jan 2012	1,200
HEALY JAMES I Director and Beneficial Owner of more than 10% of a Class of Security	Sale at price 6.22 per share.	Indirect	155,625	30 Dec 2011	25,000
SOFINNOVA VENTURE PARTNERS VI L P Beneficial Owner of more than 10% of a Class of Security	Sale at price 6.22 per share.	Indirect	155,625	30 Dec 2011	25,000
HEALY JAMES I Director and Beneficial Owner of more than 10% of a Class of Security	Sale at price 6.22 - 6.51 per share.	Indirect	318,375	22 Dec 2011	50,000
SOFINNOVA VENTURE PARTNERS VI L P Beneficial Owner of more than 10% of a Class of Security	Sale at price 6.22 - 6.51 per share.	Indirect	318,375	22 Dec 2011	50,000
TRUEX PAUL F Chief Executive Officer	Sale at price 6.34 per share.	Indirect	95,066	15 Dec 2011	15,000
ORBIMED ADVISORS, L.L.C. Unknown	Sale at price 6.50 - 6.75 per share.	Indirect	375,300	13 Dec 2011	56,200
ORBIMED ADVISORS, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Sale at price 6.50 - 6.87 per share.	Indirect	351,330	18 Nov 2011	52,000
ORBIMED ADVISORS, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Sale at price 6.93 - 7.14 per share.	Indirect	416,950	15 Nov 2011	60,000
TRUEX PAUL F Chief Executive Officer	Stock Gift at price 0.00 per share.	Direct	0	15 Nov 2011	50,000
TRUEX PAUL F Chief Executive Officer	Sale at price 6.96 per share.	Indirect	208,704	15 Nov 2011	30,000
HISLOP COLIN Officer	Sale at price 6.74 per share.	Direct	101,163	08 Nov 2011	15,000
HISLOP COLIN Officer	Conversion of Exercise of derivative security at price 0.26 per share.	Direct	3,900	08 Nov 2011	15,000
THOMPSON DAVID E Director	Stock Gift at price 0.00 per share.	Indirect	0	07 Nov 2011	3,800
LOWE CHRISTOPHER P Chairman of the Board	Sale at price 6.88 per share.	Direct	103,236	03 Nov 2011	15,000
LOWE CHRISTOPHER P Chief Financial Officer	Sale at price 7.07 per share.	Indirect	32,784	25 Oct 2011	4,637
TRUEX PAUL F Chief Executive Officer	Sale at price 6.25 per share.	Indirect	145,219	21 Oct 2011	23,235
TRUEX PAUL F Chief Executive Officer	Sale at price 6.25 per share.	Indirect	42,156	18 Oct 2011	6,745
TRUEX PAUL F Chief Executive Officer	Conversion of Exercise of derivative security at price 0.26 per share.	Direct	13,000	08 Aug 2011	50,000
LOWE CHRISTOPHER P Chairman of the Board	Conversion of Exercise of derivative security at price 1.34 per share.	Direct	13,400	08 Aug 2011	10,000
LOWE CHRISTOPHER P Chief Financial Officer	Sale at price 6.88 - 7.93 per share.	Indirect	137,003	03 Aug 2011	19,600
TRUEX PAUL F Chief Executive Officer	Sale at price 7.95 per share.	Indirect	119,258	15 Jul 2011	15,000
HISLOP COLIN Officer	Conversion of Exercise of derivative security at price 0.26 per share.	Direct	3,900	12 Jul 2011	15,000
VANTAGEPOINT VENTURE ASSOCIATES IV L L C Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 1.34 - 4.19 per share.	Indirect	47,264	07 Jul 2011	19,563
HISLOP COLIN Officer	Conversion of Exercise of derivative security at price 0.26 per share.	Direct	2,600	29 Jun 2011	10,000
LOWE CHRISTOPHER P Chief Financial Officer	Conversion of Exercise of derivative security at price 0.14 - 1.51 per share.	Direct	26,200	21 Jun 2011	20,000
VANTAGEPOINT VENTURE ASSOCIATES IV L L C Beneficial Owner of more than 10% of a Class of Security	Sale at price 8.67 per share.	Indirect	26,877	16 Jun 2011	3,100
TRUEX PAUL F Chief Executive Officer	Sale at price 8.30 per share.	Indirect	124,539	15 Jun 2011	15,000
VANTAGEPOINT VENTURE ASSOCIATES IV L L C Beneficial Owner of more than 10% of a Class of Security	Sale at price 8.80 - 8.81 per share.	Indirect	17,598	14 Jun 2011	1,999
ORBIMED ADVISORS, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Sale at price 8.02 - 8.18 per share.	Indirect	810,130	10 Jun 2011	100,000
TRUEX PAUL F Chief Executive Officer	Stock Gift at price 0.00 per share.	Direct	0	31 May 2011	5,122
ORBIMED ADVISORS, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Sale at price 8.53 - 8.65 per share.	Indirect	333,246	26 May 2011	39,000
VANTAGEPOINT VENTURE ASSOCIATES IV L L C Beneficial Owner of more than 10% of a Class of Security	Sale at price 8.60 per share.	Indirect	41,280	26 May 2011	4,800
VANTAGEPOINT VENTURE ASSOCIATES IV L L C Beneficial Owner of more than 10% of a Class of Security	Sale at price 8.18 - 8.67 per share.	Indirect	941,863	25 May 2011	111,649
VANTAGEPOINT VENTURE ASSOCIATES IV L L C Beneficial Owner of more than 10% of a Class of Security	Sale at price 8.03 - 8.29 per share.	Indirect	1,118,981	19 May 2011	138,900
ORBIMED ADVISORS, L.L.C. Director and Beneficial Owner of more than 10% of a Class of Security	Sale at price 7.20 - 8.32 per share.	Indirect	1,475,152	18 May 2011	181,334
TRUEX PAUL F Chief Executive Officer	Sale at price 7.16 per share.	Indirect	107,338	16 May 2011	15,000
ORBIMED ADVISORS, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Sale at price 7.22 - 7.26 per share.	Indirect	935,732	11 May 2011	129,400
TRUEX PAUL F Chief Executive Officer	Stock Gift at price 0.00 per share.	Indirect	0	09 May 2011	39,000
VANTAGEPOINT VENTURE ASSOCIATES IV L L C Beneficial Owner of more than 10% of a Class of Security	Sale at price 7.00 - 7.01 per share.	Indirect	4,817,777	05 May 2011	687,700
TRUEX PAUL F Chief Executive Officer	Conversion of Exercise of derivative security at price 0.26 per share.	Direct	7,800	13 Apr 2011	30,000
ODINK DEBRA A Officer and Director	Conversion of Exercise of derivative security at price 1.51 per share.	Direct	5,000	13 Apr 2011	3,311
TRUEX PAUL F Chief Executive Officer	Stock Gift at price 0.00 per share.	Indirect	0	07 Apr 2011	700,503
LOWE CHRISTOPHER P Officer	Sale at price 3.85 per share.	Indirect	311,838	11 Feb 2011	80,997
THOMPSON DAVID E Director	Conversion of Exercise of derivative security at price 1.34 - 1.51 per share.	Indirect	16,067	03 Jan 2011	11,558
ORBIMED ADVISORS, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Purchase at price 4.08 per share.	Indirect	81,192	30 Sept 2010	19,900
LOWE CHRISTOPHER P Officer	Purchase at price 4.18 per share.	Direct	20,900	24 Sept 2010	5,000
ODINK DEBRA A Officer	Purchase at price 4.20 per share.	Direct	4,200	24 Sept 2010	1,000
HISLOP COLIN Officer	Conversion of Exercise of derivative security at price 0.26 per share.	Indirect	3,818	21 Sept 2010	14,683
TRIAS JOAQUIM Officer	Conversion of Exercise of derivative security at price 1.51 per share.	Direct	6,614	21 Sept 2010	4,380
HISLOP COLIN Officer	Purchase at price 4.80 per share.	Indirect	2,400	18 Aug 2010	500
TRUEX PAUL F Chief Executive Officer	Stock Gift at price 0.00 per share.	Direct	0	13 Jul 2010	23,364
TRUEX PAUL F Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	30 Jun 2010	86,000
ODINK DEBRA A Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	30 Jun 2010	25,000
HISLOP COLIN Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	30 Jun 2010	40,000
LAU STEPHEN Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	30 Jun 2010	7,000
TRIAS JOAQUIM Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	30 Jun 2010	20,000
FRITSCH URSULA Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	30 Jun 2010	10,500
KILFOIL GEORGINA H Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	30 Jun 2010	22,500
TRUEX PAUL F Chief Executive Officer	Conversion of Exercise of derivative security at price 0.14 per share.	Direct	3,271	07 Apr 2010	23,364
HENNEY CHRISTOPHER S Director	Conversion of Exercise of derivative security at price 0.26 - 1.51 per share.	Direct	49,473	01 Apr 2010	40,887
LOWE CHRISTOPHER P Chief Financial Officer	Conversion of Exercise of derivative security at price 0.14 - 0.26 per share.	Indirect	2,155	31 Mar 2010	9,637
HENNEY CHRISTOPHER S Director	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	04 Mar 2010	46,940
HEALY JAMES I Director	Stock Award(Grant) at price 6.58 - 7.00 per share.	Indirect	8,462,757	04 Mar 2010	1,253,635
HEALY JAMES I Director	Conversion of Exercise of derivative security at price 0.00 - 6.58 per share.	Indirect	4,097,698	04 Mar 2010	2,818,568
TRUEX PAUL F Chief Executive Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	04 Mar 2010	29,286
VANTAGEPOINT VENTURE ASSOCIATES IV L L C Beneficial Owner of more than 10% of a Class of Security	Stock Award(Grant) at price 6.58 - 7.00 per share.	Indirect	12,967,378	04 Mar 2010	1,921,656
VANTAGEPOINT VENTURE ASSOCIATES IV L L C Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 0.00 - 6.58 per share.	Indirect	6,344,222	04 Mar 2010	4,364,460
LOWE CHRISTOPHER P Chief Financial Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Indirect	0	04 Mar 2010	98,520
SOFINNOVA VENTURE PARTNERS VI L P Beneficial Owner of more than 10% of a Class of Security	Stock Award(Grant) at price 7.00 per share.	Indirect	622,811	04 Mar 2010	88,973
SOFINNOVA VENTURE PARTNERS VI L P Beneficial Owner of more than 10% of a Class of Security	Stock Award(Grant) at price 6.58 - 7.00 per share.	Indirect	8,462,757	04 Mar 2010	1,253,635
SOFINNOVA VENTURE PARTNERS VI L P Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 0.00 per share.	Indirect	0	04 Mar 2010	2,818,569
ODINK DEBRA A Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Indirect	0	04 Mar 2010	17,523
TRIAS JOAQUIM Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	04 Mar 2010	17,523
FRITSCH URSULA Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	04 Mar 2010	17,523
LEHENY A RACHEL Director	Stock Award(Grant) at price 6.58 - 7.00 per share.	Indirect	2,577,332	04 Mar 2010	381,120
LEHENY A RACHEL Director	Conversion of Exercise of derivative security at price 0.00 - 6.58 per share.	Indirect	1,347,021	04 Mar 2010	815,797
TRUEX PAUL F Chief Executive Officer	Purchase at price 7.05 - 7.19 per share.	Direct	7,117	01 Mar 2010	1,000

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Insider transactions

Insider transactions reported - last two years

NIKKEI 225
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HANG SENG
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