Insider	Transaction	Type	Value	Date	Shares
Odey Asset Management Group, Ltd.	Bought at price 0.28 per share.	Direct	6,791,999	21 Oct 2022	24,000,000
Glatz (Philippe)		Direct		17 Aug 2022	0
Plowman (Piers Nicholas)	Bought at price 0.31 per share.	Direct	48,960	10 Aug 2022	160,000
Bradfield (Michael Stephen)	Bought at price 0.31 per share.	Direct	90,576	10 Aug 2022	296,000
Sinclair (Michael Jeffrey)	Bought at price 0.31 per share.	Direct	131,580	10 Aug 2022	430,000
Van Celsing (Hans)	Bought at price 0.31 per share.	Direct	89,759	10 Aug 2022	293,332
Vanni (Enrico Cipro)	Bought at price 0.31 per share.	Direct	153,000	10 Aug 2022	500,000
Yantai CIPU Medical Technology co Ltd	Bought at price 0.31 per share.	Direct	77,519	10 Aug 2022	253,332
Cross (Lori J)	Bought at price 0.31 per share.	Direct	71,399	10 Aug 2022	233,332
Odey Asset Management Group, Ltd.		Direct		01 Jul 2022	18,000,000
Odey Asset Management Group, Ltd.		Direct		26 May 2022	0
Mulligan (Seamus)		Direct		16 Mar 2022	0
Myers (Steve)		Direct		16 Mar 2022	0
Plowman (Piers Nicholas)		Direct		16 Mar 2022	0
Celeste Management SA		Direct		16 Mar 2022	0
Cross (Lori J)		Direct		16 Mar 2022	0
DNCA Finance		Direct		16 Mar 2022	0
Glatz (Philippe)		Direct		16 Mar 2022	0
Bradfield (Michael Stephen)		Direct		16 Mar 2022	0
Van Celsing (Hans)		Direct		16 Mar 2022	0
Vanni (Enrico Cipro)		Direct		16 Mar 2022	0
Yantai CIPU Medical Technology co Ltd		Direct		16 Mar 2022	0
Serandour (Nicolas)		Direct		16 Mar 2022	0
Sinclair (Michael Jeffrey)		Direct		16 Mar 2022	0
Sinclair (Michael Jeffrey)	Bought at price 0.38 per share.	Direct	37,500	02 Mar 2022	100,000
Myers (Steve)	Bought at price 0.35 per share.	Direct	8,700	02 Mar 2022	25,000
Myers (Steve)	Bought at price 0.38 per share.	Direct	43,125	02 Mar 2022	115,000
Vanni (Enrico Cipro)	Bought at price 0.36 per share.	Direct	36,200	02 Mar 2022	100,000
DNCA Finance		Direct		24 Feb 2022	0
Glatz (Philippe)		Direct		10 Dec 2021	30,000,000
DNCA Finance		Direct		03 Dec 2021	7,500,000
Mulligan (Seamus)		Direct		04 Nov 2021	0
Celeste Management SA		Direct		24 Sept 2021	0
Celeste Management SA		Direct		12 Jul 2021	0
DNCA Finance		Direct		12 Jul 2021	0
Glatz (Philippe)		Direct		12 Jul 2021	0
Hargreaves Lansdown Asset Management Ltd.		Direct		12 Jul 2021	0
Lombard Odier Asset Management (Europe) Ltd		Direct		12 Jul 2021	0
Van Celsing (Hans)		Direct		12 Jul 2021	0
Vanni (Enrico Cipro)		Direct		12 Jul 2021	0
Yantai CIPU Medical Technology co Ltd		Direct		12 Jul 2021	0
Serandour (Nicolas)		Direct		12 Jul 2021	0
Sinclair (Michael Jeffrey)		Direct		12 Jul 2021	0
Mulligan (Seamus)		Direct		12 Jul 2021	0
Myers (Steve)		Direct		12 Jul 2021	0
Plowman (Piers Nicholas)		Direct		12 Jul 2021	0
Bradfield (Michael Stephen)		Direct		12 Jul 2021	0
Yantai CIPU Medical Technology co Ltd		Direct		31 May 2021	0
Celeste Management SA		Direct		31 May 2021	0
DNCA Finance		Direct		31 May 2021	0
Glatz (Philippe)		Direct		31 May 2021	0
Hargreaves Lansdown Asset Management Ltd.		Direct		31 May 2021	0
Lombard Odier Asset Management (Europe) Ltd		Direct		31 May 2021	0
Mulligan (Seamus)		Direct		31 May 2021	0
Yantai CIPU Medical Technology co Ltd		Direct		05 Feb 2021	0
Van Celsing (Hans)		Direct		31 Dec 2020	0
Vanni (Enrico Cipro)		Direct		31 Dec 2020	0
Yantai CIPU Medical Technology co Ltd		Direct		31 Dec 2020	0
Myers (Steve)		Direct		31 Dec 2020	0
Plowman (Piers Nicholas)		Direct		31 Dec 2020	0
Serandour (Nicolas)		Direct		31 Dec 2020	0
Bradfield (Michael Stephen)		Direct		31 Dec 2020	0
Sinclair (Michael Jeffrey)		Direct		31 Dec 2020	0
Plowman (Piers Nicholas)	Bought at price 0.39 per share.	Direct	97,000	30 Oct 2020	250,000
Van Celsing (Hans)	Bought at price 0.39 per share.	Direct	97,000	30 Oct 2020	250,000
Vanni (Enrico Cipro)	Bought at price 0.39 per share.	Direct	97,000	30 Oct 2020	250,000
Yantai CIPU Medical Technology co Ltd		Direct		30 Oct 2020	0
Celeste Management SA		Direct		30 Oct 2020	8,333,333
Bradfield (Michael Stephen)	Bought at price 0.39 per share.	Direct	97,000	30 Oct 2020	250,000
Glatz (Philippe)		Direct		30 Oct 2020	0
Sinclair (Michael Jeffrey)	Bought at price 0.42 per share.	Direct	60,755	17 Aug 2020	145,000
Mulligan (Seamus)		Direct		17 Jun 2020	0
Mulligan (Seamus)		Direct		09 Jun 2020	0
Plowman (Piers Nicholas)		Direct		09 Jun 2020	0
Serandour (Nicolas)		Direct		09 Jun 2020	0
Sinclair (Michael Jeffrey)		Direct		09 Jun 2020	0
UBS Asset Management		Direct		09 Jun 2020	0
Urwitz (Gabriel)		Direct		09 Jun 2020	0
Van Celsing (Hans)		Direct		09 Jun 2020	0
Vanni (Enrico Cipro)		Direct		09 Jun 2020	0
Yantai CIPU Medical Technology co Ltd		Direct		09 Jun 2020	0
Hargreaves Lansdown Asset Management Ltd.		Direct		09 Jun 2020	0
Lombard Odier Asset Management (Europe) Ltd		Direct		09 Jun 2020	0
Baltisches Haus		Direct		09 Jun 2020	0
Bradfield (Michael Stephen)		Direct		09 Jun 2020	0
Brahma AG		Direct		09 Jun 2020	0
Celeste Management SA		Direct		09 Jun 2020	0
DNCA Finance		Direct		09 Jun 2020	0
Glatz (Philippe)		Direct		09 Jun 2020	0
Brahma AG		Direct		29 May 2020	0
Celeste Management SA		Direct		29 May 2020	0
DNCA Finance		Direct		29 May 2020	0
Glatz (Philippe)		Direct		29 May 2020	0
Yantai CIPU Medical Technology co Ltd		Direct		29 May 2020	0
Mulligan (Seamus)		Direct		29 May 2020	0
Sinclair (Michael Jeffrey)		Direct		29 May 2020	0
Baltisches Haus		Direct		29 May 2020	0
Lombard Odier Asset Management (Europe) Ltd		Direct		29 May 2020	0
Myers (Steve)	Bought at price 0.30 per share.	Direct	60,600	15 May 2020	200,000
Plowman (Piers Nicholas)	Bought at price 0.30 per share.	Direct	36,360	15 May 2020	120,000
Van Celsing (Hans)	Bought at price 0.30 per share.	Direct	36,360	15 May 2020	120,000
Vanni (Enrico Cipro)	Bought at price 0.30 per share.	Direct	90,900	15 May 2020	300,000
Vanni (Enrico Cipro)	Bought at price 0.30 per share.	Direct	36,360	15 May 2020	120,000
Sinclair (Michael Jeffrey)	Bought at price 0.30 per share.	Direct	121,200	15 May 2020	400,000
Sinclair (Michael Jeffrey)	Bought at price 0.30 per share.	Direct	80,581	15 May 2020	265,944
Urwitz (Gabriel)	Bought at price 0.30 per share.	Direct	18,180	15 May 2020	60,000
Brahma AG		Direct		13 May 2020	0
Celeste Management SA		Direct		13 May 2020	0
Brahma AG		Direct		08 Jan 2020	0
DNCA Finance		Direct		08 Jan 2020	0
Glatz (Philippe)		Direct		08 Jan 2020	0
Sinclair (Michael Jeffrey)		Direct		08 Jan 2020	0
UBS Asset Management		Direct		08 Jan 2020	0
Urwitz (Gabriel)		Direct		08 Jan 2020	0
Myers (Steve)		Direct		08 Jan 2020	0
Peter Gyllenhammar AB		Direct		08 Jan 2020	0
Plowman (Piers Nicholas)		Direct		08 Jan 2020	0
Serandour (Nicolas)		Direct		08 Jan 2020	0
Handelsbanken Asset Management		Direct		08 Jan 2020	0
Hargreaves Lansdown Asset Management Ltd.		Direct		08 Jan 2020	0
Kambara International KK		Direct		08 Jan 2020	0
Khattar (Navin)		Direct		08 Jan 2020	0
Lombard Odier Asset Management (Europe) Ltd		Direct		08 Jan 2020	0
M3T Pte. Ltd.		Direct		08 Jan 2020	0
Miola (Adriano)		Direct		08 Jan 2020	0
Mulligan (Seamus)		Direct		08 Jan 2020	0
Van Celsing (Hans)		Direct		08 Jan 2020	0
Vanni (Enrico Cipro)		Direct		08 Jan 2020	0
Yantai CIPU Medical Technology co Ltd		Direct		08 Jan 2020	0
Baltisches Haus		Direct		08 Jan 2020	0
Bradfield (Michael Stephen)		Direct		08 Jan 2020	0
Baltisches Haus		Direct		31 Dec 2019	0
Bradfield (Michael Stephen)		Direct		31 Dec 2019	0
Mulligan (Seamus)		Direct		31 Dec 2019	0
Myers (Steve)		Direct		31 Dec 2019	0
Plowman (Piers Nicholas)		Direct		31 Dec 2019	0
Serandour (Nicolas)		Direct		31 Dec 2019	0
Brahma AG		Direct		31 Dec 2019	0
DNCA Finance		Direct		31 Dec 2019	0
Glatz (Philippe)		Direct		31 Dec 2019	0
Sinclair (Michael Jeffrey)		Direct		31 Dec 2019	0
Urwitz (Gabriel)		Direct		31 Dec 2019	0
Van Celsing (Hans)		Direct		31 Dec 2019	0
Vanni (Enrico Cipro)		Direct		31 Dec 2019	0
Yantai CIPU Medical Technology co Ltd		Direct		31 Dec 2019	0
Lombard Odier Asset Management (Europe) Ltd		Direct		31 Dec 2019	0
Handelsbanken Asset Management		Direct		05 Dec 2019	0
Hargreaves Lansdown Asset Management Ltd.		Direct		05 Dec 2019	0
Kambara International KK		Direct		05 Dec 2019	0
Lombard Odier Asset Management (Europe) Ltd		Direct		05 Dec 2019	0

FTSE 1008,305.54+92.05(+1.12%)

FTSE 25020,373.42+208.88(+1.04%)

AIM777.35+5.82(+0.75%)

GBP/EUR1.1648-0.0012(-0.10%)

GBP/USD1.2539-0.0025(-0.20%)

Bitcoin GBP51,309.75-845.66(-1.62%)

The retirement income gap no-one is talking about

Advanced Oncotherapy plc (AVO.L)

Insider transactions

Insider transactions reported - last two years

FTSE 100
8,305.54
+92.05(+1.12%)

FTSE 250
20,373.42
+208.88(+1.04%)

AIM
777.35
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GBP/EUR
1.1648
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GBP/USD
1.2539
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Bitcoin GBP
51,309.75
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