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AstraZeneca PLC (AZN.L)

LSE - LSE Delayed price. Currency in GBp
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8,109.00-108.00 (-1.31%)
At close: 4:37PM BST
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  • S
    Soopa
    DoD IMMEDIATE RELEASE

    Trump Administration Expands Collaboration With AstraZeneca to Develop and Manufacture an Investigational Monoclonal Antibody to Prevent COVID-19
    OCT. 14, 2020
    To meet the Trump Administration’s Operation Warp Speed goals, the U.S. Department of Health and Human Services (HHS) and Department of Defense (DOD) today announced an agreement with AstraZeneca for late-stage development and large-scale manufacturing of the company’s COVID-19 investigational product AZD7442, a cocktail of two monoclonal antibodies, that may help treat or prevent infection with SARS-CoV-2, the coronavirus that causes COVID-19.

    The goal of AstraZeneca’s partnership with the U.S. Government is to develop a monoclonal antibody cocktail that can help prevent infection. An effective monoclonal antibody that can prevent COVID-19, particularly one that is long-lasting and delivered by intramuscular injection, may be of particular use in certain groups. This includes people who have compromised immune function, those who are over 80 years old, and people undergoing medical treatments that preclude them from receiving a COVID-19 vaccine. If the FDA authorizes use of AZD7442 for prevention of SARS-CoV-2, as outlined in agency guidance, the federal government will distribute the doses at no cost. As is customary with government-purchased medical products, healthcare professionals could charge for the cost of administering the product.

    The Biomedical Advanced Research and Development Authority (BARDA), part of the HHS Office of the Assistant Secretary for Preparedness and Response, collaborated with the DoD Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense and Army Contracting Command, to provide approximately $486 million to AstraZeneca for two Phase 3 clinical trials and related development activities, including a large-scale manufacturing demonstration project and supply of AZD7442 doses in the United States.

    One of the Phase 3 clinical trials of AZD7442 will evaluate safety and efficacy of the product to prevent infection for up to 12 months in approximately 5,000 volunteers. An additional Phase 3 clinical study will evaluate if AZD7442 can help prevent infection in people who have come in contact with someone with COVID-19 in a post-exposure prophylaxis setting. This second study will enroll approximately 1,100 volunteers. The company estimates 100,000 doses of AZD 7442 could be available from this project for the nation’s high-risk population that may not benefit from a vaccine by December 2020.

    “In addition to Operation Warp Speed’s historic progress on vaccines, we are supporting promising monoclonal antibodies for prevention and treatment all the way through to supply, allowing faster distribution if trials are successful,” said HHS Secretary Alex Azar. “More good news about COVID-19 treatments is constantly emerging, and President Trump’s commitment to supporting lifesaving measures, like AstraZeneca’s antibody candidate which may help deliver these products to our nation’s most vulnerable populations.”

    Working in parallel across clinical development and manufacturing supply will accelerate the traditional product development timeline, should clinical trials prove successful and the U.S. Food and Drug Administration (FDA) authorize use of the medicine.

    AZD7442 is a combination of two monoclonal antibodies discovered by Vanderbilt University, licensed to AstraZeneca and modified using AstraZeneca’s proprietary half-life extension technology to extend their duration of action (the amount of time that the antibodies remain in the body). Monoclonal antibodies synthesized in the laboratory aim to mimic natural antibodies and are delivered by injection or infusion. The antibodies bind to the SARS-CoV-2 virus spike protein, reducing the ability of the virus to infect human cells. The long-acting monoclonal antibody combination neutralizes the SARS-CoV-2, and has the potential to increase effectiveness and durability of the prevention of infection.

    Preclinical and clinical development for this antiviral has been supported in part through an existing partnership among BARDA, the Defense Advanced Research Projects Agency, Vanderbilt University and AstraZeneca
  • S
    Scott
    You buy the "dips" and hold for an easy Triple if AZN coronavirus is approved. And in a week or so AZN should restart trials in U.S. thus pushing it over $70 a share. MRNA is a one trick pony and JNJ and Eli Lilly have both been halted. Pfe and BnTx have to supper freeze their vaccine and no one is set up to handle that on a mass quantity. Heck there are not enough deep freezer to store Bntx vaccine, much less enough dry ice to ship it. In other words Pfizer can't distribute, even if has the goods.

    AZN stock is cheap right now but you need to buy before it pops over $65 a share this month, if not sooner.
  • J
    Juan
    All Aboard -
    AstraZeneca gets $486M to test if COVID-19 antibodies can provide 12 months of protection

    https://www.fiercebiotech.com/biotech/astrazeneca-gets-486m-to-test-if-covid-19-antibodies-can-provide-12-months-protection
  • L
    Leee
    PUBLISHED 9 October 2020
    9 October 2020 21:30 BST

    Two trials of AZD7442 will enrol over 6,000 adults for the prevention of COVID-19 with additional trials enrolling ~4,000 adults for the treatment of SARS-CoV-2 infections
    US Government to invest ~$486m for development and supply of up to 100,000 doses and can acquire another one million doses
  • S
    Steve
    Breaking News - Jerry will not only lose his house "shorting AZN" but also his 2003 dented Camry. Wife left several months ago due to his "short stock" gambling habit and now he's just weeks away from home foreclosure. Keep posting Jerry, since everyone knows you'll be gone by next week if not sooner.
  • w
    win
    "Overall, AZN scores a Strong Buy consensus from the analyst community with 4 unanimous Buy ratings. Looking ahead, the $77.38 average analyst price target puts the upside potential at a promising 41% in the coming 12 months."
  • G
    Green Machine
    This is an awesome buy in point now to get a good deal on some AstraZenca stock. We are below the 50 day moving average, and the RSI is at 21 signaling that this is Oversold. Good luck all!
  • G
    Green Machine
    I think we'll erase this 1/2 percent loss and close in the green today. This is a good entry price right now. I don't think it will be too much longer before this goes on a several day run and gets up over $60 again. Good luck all!
  • G
    Green Machine
    This is a HUGE company, which is a slow but steady gainer over time. And, it also pays a good dividend while you wait for your gains. It doesn't move up super fast usually, but at the same time, it doesn't take large quick dips either. Plus, it has the potential to jump up a little bit once the results of the phase 2/3 vaccine trial are released. Good luck to all!
  • V
    Vlad
    A full vaccine roll-out programme could take six months or less after approval, said UK government sources quoted in the report.
    A full vaccine roll-out programme could take six months or less after approval, said UK government sources quoted in the report.
    theprint.in
  • M
    Mary Williams
    Not Good - One month to turn over data to FDA??? Something smells fishy here.

    https://www.cnn.com/2020/10/14/health/astrazeneca-covid-vaccine-trial/index.html
  • G
    Green Machine
    Cup and handle forming in the chart. We should be set up for a decent wave up next week. This is a good time to get in. Good luck everyone!
  • B
    Birwa
    FYI.... AZN IS NOT A COVID STOCK. So all you shorts, who are only interested in quick money, please get the hell out of here. AstraZeneca is huge and very successful pharmaceutical company. It is a long term investment stock.
    Whoever is not interested in staying long, should go and find your lottery stock which will make you rich overnight. 🙏🏽🙏🏽
  • S
    Scott
    Boom - AstraZeneca agrees to provide 100 million doses of its vaccine candidate to Indonesia by the first half of 2021, the country's foreign minister said Wednesday.

    Sure sound like AZN's phase 3 trial is going very well for Indonesia to want 100 million doses first half of 2021. Thus time to buy hand over fist.
  • G
    Green Machine
    I'm guessing that this will trade in the $55.50 to $57 range next week since we had this nice increase today. Good luck to all!
  • L
    Leee
    BOOM...AZN gets 486 million from USA. Two Phase 3 studies going on too. Up next week. Monoclonal antibody booyah for longs !!!!!!!!!!!!!!