Insider	Transaction	Type	Value	Date	Shares
AFEYAN NOUBAR BOGHOS Director and Beneficial Owner of more than 10% of a Class of Security	Sale at price 0.56 per share.	Indirect	26,005	09 Dec 2015	46,438
AFEYAN NOUBAR BOGHOS Director and Beneficial Owner of more than 10% of a Class of Security	Sale at price 2.27 per share.	Indirect	11,305	27 Jul 2015	4,980
AFEYAN NOUBAR BOGHOS Director and Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 0.14 per share.	Indirect	11,072	27 Jul 2015	79,087
AFEYAN NOUBAR BOGHOS Director and Beneficial Owner of more than 10% of a Class of Security	Sale at price 2.27 per share.	Indirect	686	27 Jul 2015	302
AFEYAN NOUBAR BOGHOS Director and Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 0.14 per share.	Indirect	669	27 Jul 2015	4,780
AFEYAN NOUBAR BOGHOS Director and Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 0.00 per share.	Indirect	0	14 Jul 2015	183,971
KANIA EDWIN M JR Beneficial Owner of more than 10% of a Class of Security	Sale at price 0.30 - 0.36 per share.	Indirect	200,537	11 Dec 2014	634,390
AFEYAN NOUBAR BOGHOS Director and Beneficial Owner of more than 10% of a Class of Security	Sale at price 0.46 per share.	Indirect	31	03 Dec 2014	68
AFEYAN NOUBAR BOGHOS Director and Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 0.02 - 0.04 per share.	Indirect	139	03 Dec 2014	6,483
AFEYAN NOUBAR BOGHOS Director and Beneficial Owner of more than 10% of a Class of Security	Sale at price 0.46 per share.	Indirect	120	03 Dec 2014	260
AFEYAN NOUBAR BOGHOS Director and Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 0.02 - 0.04 per share.	Indirect	141	03 Dec 2014	6,536
AFEYAN NOUBAR BOGHOS Director and Beneficial Owner of more than 10% of a Class of Security	Sale at price 0.46 per share.	Indirect	1,133	03 Dec 2014	2,463
AFEYAN NOUBAR BOGHOS Director and Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 0.02 - 0.04 per share.	Indirect	1,332	03 Dec 2014	54,558
AFEYAN NOUBAR BOGHOS Director and Beneficial Owner of more than 10% of a Class of Security	Sale at price 0.46 per share.	Indirect	850	03 Dec 2014	1,848
AFEYAN NOUBAR BOGHOS Director and Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 0.02 per share.	Indirect	1,025	03 Dec 2014	51,240
SOHMER PAUL R Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	16 Oct 2014	327,900
HALL STEPHEN P Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	16 Oct 2014	190,200
ADOURIAN ARAM S Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	16 Oct 2014	157,800
ADOURIAN ARAM S Officer	Conversion of Exercise of derivative security at price 0.90 per share.	Direct	10,800	14 Apr 2014	12,000
PAPADOPOULOS STELIOS B Director	Purchase at price 2.00 per share.	Direct	500,000	30 Jan 2013	250,000
AFEYAN NOUBAR BOGHOS Director and Beneficial Owner of more than 10% of a Class of Security	Purchase at price 2.00 per share.	Indirect	4,000,000	30 Jan 2013	2,000,000
POSNER BRIAN S. Director	Purchase at price 1.17 per share.	Direct	11,650	19 Nov 2012	10,000
BANCEL STEPHANE J Officer and Director	Purchase at price 1.26 per share.	Direct	126,000	15 Nov 2012	100,000
BANCEL STEPHANE J Chairman of the Board	Purchase at price 3.70 per share.	Direct	5,110	13 Sept 2012	1,381
AFEYAN NOUBAR BOGHOS Director and Beneficial Owner of more than 10% of a Class of Security	Sale at price 5.83 per share.	Indirect	478	20 Aug 2012	82
AFEYAN NOUBAR BOGHOS Director and Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 0.02 - 0.03 per share.	Indirect	456	20 Aug 2012	21,619
MUNTENDAM PIETER Officer	Sale at price 5.29 - 5.50 per share.	Direct	186,090	08 Jun 2012	33,986
MUNTENDAM PIETER Officer	Conversion of Exercise of derivative security at price 0.90 per share.	Direct	90,000	30 May 2012	100,000
BOUVIER ERIC Chief Executive Officer	Purchase at price 3.95 per share.	Direct	39,500	23 May 2012	10,000
POSNER BRIAN S. Director	Purchase at price 4.04 per share.	Direct	40,400	22 May 2012	10,000
AFEYAN NOUBAR BOGHOS Director and Beneficial Owner of more than 10% of a Class of Security	Sale at price 3.95 per share.	Indirect	557	21 May 2012	141
AFEYAN NOUBAR BOGHOS Director and Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 0.02 - 0.03 per share.	Indirect	547	21 May 2012	26,080
BANCEL STEPHANE J Officer and Director	Purchase at price 3.84 per share.	Direct	19,231	17 May 2012	5,008
BANCEL STEPHANE J Officer and Director	Purchase at price 3.84 per share.	Direct	19,231	17 May 2012	5,008
VAN DER MEER PIETER Beneficial Owner of more than 10% of a Class of Security	Sale at price 6.60 per share.	Indirect	1,320,000	17 Apr 2012	200,000
ADOURIAN ARAM S Officer	Conversion of Exercise of derivative security at price 0.90 per share.	Direct	6,308	19 Mar 2012	7,009
BANCEL STEPHANE J Officer and Director	Purchase at price 7.84 per share.	Direct	21,780	22 Feb 2012	2,778
PAPADOPOULOS STELIOS B Director	Sale at price 4.01 per share.	Direct	4,323	29 Nov 2011	1,078
PAPADOPOULOS STELIOS B Director	Conversion of Exercise of derivative security at price 0.02 - 0.03 per share.	Direct	4,303	29 Nov 2011	151,616
PAPADOPOULOS STELIOS B Director	Conversion of Exercise of derivative security at price 0.90 per share.	Direct	302,797	09 Nov 2011	336,441
BANCEL STEPHANE J Officer and Director	Purchase at price 3.63 - 4.40 per share.	Direct	56,567	12 Sept 2011	14,000
MUNTENDAM PIETER Chief Executive Officer	Sale at price 4.73 per share.	Direct	66	01 Sept 2011	14
MUNTENDAM PIETER Chief Executive Officer	Conversion of Exercise of derivative security at price 0.03 per share.	Direct	84	01 Sept 2011	2,803
PAPADOPOULOS STELIOS B Director	Purchase at price 7.00 per share.	Direct	525,000	09 Feb 2011	75,000
PAPADOPOULOS STELIOS B Director	Conversion of Exercise of derivative security at price 0.00 - 7.00 per share.	Direct	265,349	09 Feb 2011	375,734
AFEYAN NOUBAR BOGHOS Director and Beneficial Owner of more than 10% of a Class of Security	Purchase at price 7.00 per share.	Indirect	7,999,999	09 Feb 2011	1,142,857
AFEYAN NOUBAR BOGHOS Director and Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 0.00 - 7.00 per share.	Indirect	2,119,607	09 Feb 2011	3,588,126
MUNTENDAM PIETER Chief Executive Officer	Conversion of Exercise of derivative security at price 0.00 per share.	Direct	0	09 Feb 2011	9,680
AGTC PARTNERS L P Beneficial Owner of more than 10% of a Class of Security	Purchase at price 7.00 per share.	Indirect	1,999,998	09 Feb 2011	285,714
AGTC PARTNERS L P Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 0.00 - 7.00 per share.	Indirect	322	09 Feb 2011	2,205,751
VAN DER MEER PIETER Director and Beneficial Owner of more than 10% of a Class of Security	Purchase at price 7.00 per share.	Indirect	999,999	09 Feb 2011	142,857
VAN DER MEER PIETER Director and Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security at price 0.00 - 7.00 per share.	Indirect	1,060,150	09 Feb 2011	1,692,580

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Insider transactions

Insider transactions reported - last two years

NIKKEI 225
38,385.73
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HANG SENG
19,073.71
-41.35(-0.22%)

CRUDE OIL
78.81
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GOLD FUTURES
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DOW
39,842.04
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