| 0.00% | % of shares held by all insiders |
| 46.27% | % of shares held by institutions |
| 46.27% | % of float held by institutions |
| 69 | Number of institutions holding shares |
| Holder | Shares | Date reported | % out | Value |
|---|---|---|---|---|
| Baker Brothers Advisors, LLC | 5,509,560 | 29 Jun 2019 | 7.62% | 45,288,583 |
| Boxer Capital, LLC | 5,300,000 | 29 Jun 2019 | 7.33% | 43,566,000 |
| Morgan Stanley | 3,871,340 | 29 Jun 2019 | 5.35% | 31,822,414 |
| ArrowMark Colorado Holdings LLC | 3,693,327 | 29 Jun 2019 | 5.11% | 30,359,147 |
| Perceptive Advisors Llc | 3,609,084 | 29 Jun 2019 | 4.99% | 29,666,670 |
| Deerfield Management Company, L.P. (Series C) | 3,201,222 | 29 Jun 2019 | 4.43% | 26,314,044 |
| FMR, LLC | 1,141,119 | 29 Jun 2019 | 1.58% | 9,379,998 |
| First Midwest Bank Trust Division | 1,076,997 | 29 Jun 2019 | 1.49% | 8,852,915 |
| Invesco Ltd. | 797,417 | 29 Jun 2019 | 1.10% | 6,554,767 |
| Jennison Associates LLC | 535,211 | 29 Jun 2019 | 0.74% | 4,399,434 |
| Holder | Shares | Date reported | % out | Value |
|---|---|---|---|---|
| Fidelity OTC Portfolio | 1,038,200 | 30 Jul 2019 | 1.44% | 9,831,754 |
| Vanguard Explorer Fund, Inc. | 749,655 | 30 Jan 2019 | 1.04% | 5,060,171 |
| Meridian Growth Fund | 667,742 | 30 Mar 2019 | 0.92% | 5,148,290 |
| Meridian Small Cap Growth Fund | 620,885 | 30 Mar 2019 | 0.86% | 4,787,023 |
| Invesco Health Care Fund | 578,614 | 29 Jun 2019 | 0.80% | 4,756,207 |
| PGIM Jennison Health Sciences Fd | 401,635 | 29 Jun 2019 | 0.56% | 3,301,439 |
| Fidelity Strategic Advisors Small-Mid Cap Fund | 353,141 | 30 May 2019 | 0.49% | 3,185,331 |
| Vanguard Variable Insurance Fund-Small Company Growth | 326,023 | 30 Dec 2018 | 0.45% | 2,093,067 |
| iShares NASDAQ Biotechnology ETF | 293,621 | 30 Jul 2019 | 0.41% | 2,780,590 |
| John Hancock Small Cap Core Fd | 199,873 | 29 Jun 2019 | 0.28% | 1,642,956 |