| 0.00% | % of shares held by all insiders |
| 46.27% | % of shares held by institutions |
| 46.27% | % of float held by institutions |
| 69 | Number of institutions holding shares |
| Holder | Shares | Date reported | % out | Value |
|---|---|---|---|---|
| Baker Brothers Advisors, LLC | 5,509,560 | 30 Mar 2019 | 7.62% | 42,478,707 |
| Boxer Capital, LLC | 4,200,000 | 30 Mar 2019 | 5.81% | 32,382,000 |
| Morgan Stanley | 3,814,223 | 30 Mar 2019 | 5.27% | 29,407,659 |
| ArrowMark Colorado Holdings LLC | 3,752,573 | 30 Mar 2019 | 5.19% | 28,932,337 |
| Deerfield Management Company, L.P. (Series C) | 1,701,222 | 30 Mar 2019 | 2.35% | 13,116,421 |
| Bank Of New York Mellon Corporation | 1,421,007 | 30 Mar 2019 | 1.97% | 10,955,963 |
| FMR, LLC | 1,141,088 | 30 Mar 2019 | 1.58% | 8,797,788 |
| First Midwest Bank Trust Division | 1,131,884 | 30 Mar 2019 | 1.57% | 8,726,825 |
| Perceptive Advisors Llc | 1,128,524 | 30 Mar 2019 | 1.56% | 8,700,920 |
| Ghost Tree Capital, LLC | 850,000 | 30 Mar 2019 | 1.18% | 6,553,500 |