Insider	Transaction	Type	Value	Date	Shares
Wellcome Trust Ltd		Direct		18 Nov 2022	1,830,590
Vacher (Clive Graham)	Sold at price 1.09 per share.	Direct	49,094	10 Aug 2022	45,124
Vacher (Clive Graham)	Bought at price 1.09 per share.	Direct	49,094	10 Aug 2022	45,124
Vacher (Clive Graham)		Direct		08 Jul 2022	63,700
Vacher (Clive Graham)	Sold at price 0.96 per share.	Direct	29,672	08 Jul 2022	30,845
Euling (Ruth)		Direct		08 Jul 2022	25,669
Euling (Ruth)	Sold at price 0.96 per share.	Direct	11,956	08 Jul 2022	12,429
Harding (Rob)		Direct		08 Jul 2022	17,218
Harding (Rob)	Sold at price 0.96 per share.	Direct	8,022	08 Jul 2022	8,339
Jupiter Asset Management Ltd		Direct		08 Jun 2022	4,082,217
Odey Asset Management LLP		Direct		27 May 2022	0
Vacher (Clive Graham)		Direct		24 May 2022	0
Wellcome Trust Ltd		Direct		24 May 2022	0
Liontrust Asset Management Plc		Direct		24 May 2022	0
Loosemore (Kevin)		Direct		24 May 2022	0
Schroder Investment Management, Ltd.		Direct		24 May 2022	0
Royal London Asset Management Ltd		Direct		24 May 2022	0
Brandes Investment Partners, L.P.		Direct		24 May 2022	0
Bray (Nick)		Direct		24 May 2022	0
Aberforth Partners LLP		Direct		24 May 2022	0
Crystal Amber Fund, Ltd.		Direct		24 May 2022	0
Jupiter Asset Management Ltd		Direct		24 May 2022	0
Euling (Ruth)		Direct		24 May 2022	0
Cunha (Maria Da)		Direct		24 May 2022	0
Cunha (Maria Da)		Direct		26 Mar 2022	0
Euling (Ruth)		Direct		26 Mar 2022	0
Jupiter Asset Management Ltd		Direct		26 Mar 2022	0
Royal London Asset Management Ltd		Direct		26 Mar 2022	0
Schroder Investment Management, Ltd.		Direct		26 Mar 2022	0
Vacher (Clive Graham)		Direct		26 Mar 2022	0
Wellcome Trust Ltd		Direct		26 Mar 2022	0
Liontrust Asset Management Plc		Direct		26 Mar 2022	0
Loosemore (Kevin)		Direct		26 Mar 2022	0
Crystal Amber Fund, Ltd.		Direct		26 Mar 2022	0
Aberforth Partners LLP		Direct		26 Mar 2022	0
Brandes Investment Partners, L.P.		Direct		26 Mar 2022	0
Bray (Nick)		Direct		26 Mar 2022	0
Schroder Investment Management, Ltd.		Direct		09 Mar 2022	9,685,822
Wellcome Trust Ltd		Direct		25 Jan 2022	5,156,647
Crystal Amber Fund, Ltd.		Direct		12 Oct 2021	2,835,000
Crystal Amber Fund, Ltd.		Direct		29 Jul 2021	3,060,892
Euling (Ruth)		Direct		05 Jul 2021	116
Euling (Ruth)	Sold at price 2.59 per share.	Direct	300	05 Jul 2021	116
Jupiter Asset Management Ltd		Direct		25 Jun 2021	0
Crystal Amber Fund, Ltd.		Direct		21 Jun 2021	2,210,796
Bray (Nick)		Direct		25 May 2021	0
Cunha (Maria Da)		Direct		25 May 2021	0
Vacher (Clive Graham)		Direct		25 May 2021	0
Loosemore (Kevin)		Direct		25 May 2021	0
Liontrust Asset Management Plc		Direct		24 May 2021	0
Wellcome Trust Ltd		Direct		24 May 2021	0
Royal London Asset Management Ltd		Direct		24 May 2021	0
Schroder Investment Management, Ltd.		Direct		24 May 2021	0
Brandes Investment Partners, L.P.		Direct		24 May 2021	0
Crystal Amber Fund, Ltd.		Direct		24 May 2021	0
Aberforth Partners LLP		Direct		24 May 2021	0
Aberforth Partners LLP		Direct		27 Mar 2021	0
Crystal Amber Fund, Ltd.		Direct		27 Mar 2021	0
Brandes Investment Partners, L.P.		Direct		27 Mar 2021	0
Bray (Nick)		Direct		27 Mar 2021	0
Schroder Investment Management, Ltd.		Direct		27 Mar 2021	0
Royal London Asset Management Ltd		Direct		27 Mar 2021	0
Liontrust Asset Management Plc		Direct		27 Mar 2021	0
Loosemore (Kevin)		Direct		27 Mar 2021	0
Vacher (Clive Graham)		Direct		27 Mar 2021	0
Wellcome Trust Ltd		Direct		27 Mar 2021	0
Cunha (Maria Da)		Direct		27 Mar 2021	0
Crystal Amber Fund, Ltd.		Direct		19 Mar 2021	2,040,000
Brandes Investment Partners, L.P.		Direct		26 Jan 2021	411,645
Vacher (Clive Graham)	Sold at price 2.02 per share.	Direct	187,581	22 Dec 2020	93,000
Vacher (Clive Graham)	Bought at price 2.02 per share.	Direct	187,581	22 Dec 2020	93,000
Loosemore (Kevin)	Sold at price 2.20 per share.	Direct	1,099,000	30 Nov 2020	500,000
Loosemore (Kevin)	Bought at price 2.20 per share.	Direct	1,120,980	30 Nov 2020	510,000
Crystal Amber Fund, Ltd.		Direct		30 Oct 2020	338,527
Crystal Amber Fund, Ltd.		Direct		16 Oct 2020	12,196,402
Schroder Investment Management, Ltd.		Direct		06 Aug 2020	13,587,002
Brandes Investment Partners, L.P.		Direct		21 Jul 2020	2,118,151
Brandes Investment Partners, L.P.		Direct		13 Jul 2020	452,262
Brandes Investment Partners, L.P.		Direct		10 Jul 2020	272,954
Brandes Investment Partners, L.P.		Direct		08 Jul 2020	537,478
Brandes Investment Partners, L.P.		Direct		07 Jul 2020	16,234,179
Brandes Investment Partners, L.P.		Direct		07 Jul 2020	9,941,576
Brandes Investment Partners, L.P.		Direct		07 Jul 2020	3,165,989
Crystal Amber Fund, Ltd.		Direct		07 Jul 2020	17,439,563
Cunha (Maria Da)	Bought at price 1.37 per share.	Direct	34,072	06 Jul 2020	24,798
Challah (Sabri)	Bought at price 1.37 per share.	Direct	2,043	06 Jul 2020	1,487
Bray (Nick)	Bought at price 1.37 per share.	Direct	11,029	06 Jul 2020	8,027
Loosemore (Kevin)	Bought at price 1.37 per share.	Direct	1,261,112	06 Jul 2020	917,840
Vacher (Clive Graham)	Bought at price 1.37 per share.	Direct	216,664	06 Jul 2020	157,689
Crystal Amber Fund, Ltd.		Direct		01 Jul 2020	5,890,152
Brandes Investment Partners, L.P.		Direct		19 Jun 2020	1,084,492
Brandes Investment Partners, L.P.		Direct		17 Jun 2020	0
Bray (Nick)		Direct		17 Jun 2020	0
Crystal Amber Fund, Ltd.		Direct		17 Jun 2020	0
Cunha (Maria Da)		Direct		17 Jun 2020	0
Challah (Sabri)		Direct		17 Jun 2020	0
Aberforth Partners LLP		Direct		17 Jun 2020	0
Vacher (Clive Graham)		Direct		17 Jun 2020	0
Liontrust Asset Management Plc		Direct		17 Jun 2020	0
Loosemore (Kevin)		Direct		17 Jun 2020	0
Schroder Investment Management, Ltd.		Direct		17 Jun 2020	0
Majedie Asset Management, Ltd.		Direct		17 Jun 2020	0
Royal London Asset Management Ltd		Direct		17 Jun 2020	0
Royal London Asset Management Ltd		Direct		15 Jun 2020	0
Majedie Asset Management, Ltd.		Direct		15 Jun 2020	0
Liontrust Asset Management Plc		Direct		15 Jun 2020	0
Schroder Investment Management, Ltd.		Direct		15 Jun 2020	0
Aberforth Partners LLP		Direct		15 Jun 2020	0
Brandes Investment Partners, L.P.		Direct		15 Jun 2020	0
Crystal Amber Fund, Ltd.		Direct		15 Jun 2020	0
Cunha (Maria Da)		Direct		28 Mar 2020	0
Bray (Nick)		Direct		28 Mar 2020	0
Challah (Sabri)		Direct		28 Mar 2020	0
Loosemore (Kevin)		Direct		28 Mar 2020	0
Vacher (Clive Graham)		Direct		28 Mar 2020	0
Crystal Amber Fund, Ltd.		Direct		24 Mar 2020	475,566
Crystal Amber Fund, Ltd.		Direct		19 Mar 2020	1,455,360
Brandes Investment Partners, L.P.		Direct		05 Mar 2020	11,094
Crystal Amber Fund, Ltd.		Direct		03 Mar 2020	1,279,653
Crystal Amber Fund, Ltd.		Direct		21 Feb 2020	1,795,482
Norges Bank Investment Management (NBIM)		Direct		28 Jan 2020	290,996
Brandes Investment Partners, L.P.		Direct		06 Jan 2020	491,052
Brandes Investment Partners, L.P.		Direct		03 Jan 2020	361,875
Easton (Joanne)	Sold at price 1.75 per share.	Direct	8,864	17 Dec 2019	5,077
Easton (Joanne)	Bought at price 1.76 per share.	Direct	8,828	17 Dec 2019	5,019
Easton (Joanne)	Bought at price 1.66 per share.	Direct	10,146	12 Dec 2019	6,120
Easton (Joanne)		Direct		03 Dec 2019	10,748
Easton (Joanne)	Sold at price 1.83 per share.	Direct	9,288	03 Dec 2019	5,070
Clint (Andrew)		Direct		03 Dec 2019	16,775
Clint (Andrew)	Sold at price 1.83 per share.	Direct	14,496	03 Dec 2019	7,913
Walker (Giles)		Direct		03 Dec 2019	1,397
Walker (Giles)	Sold at price 1.83 per share.	Direct	2,559	03 Dec 2019	1,397
Crystal Amber Fund, Ltd.		Direct		29 Nov 2019	7,493,939
Euling (Ruth)	Bought at price 1.87 per share.	Direct	18,720	28 Nov 2019	10,000
Peppiatt (Edward H. D.)	Bought at price 1.80 per share.	Direct	79,239	27 Nov 2019	44,120
Vacher (Clive Graham)	Bought at price 1.77 per share.	Direct	66,562	26 Nov 2019	37,500
Vacher (Clive Graham)	Bought at price 1.77 per share.	Direct	6,656	26 Nov 2019	3,750
Vacher (Clive Graham)	Bought at price 1.77 per share.	Direct	6,656	26 Nov 2019	3,750
Vacher (Clive Graham)	Bought at price 1.77 per share.	Direct	6,656	26 Nov 2019	3,750
Norges Bank Investment Management (NBIM)		Direct		12 Nov 2019	313,671
Crystal Amber Fund, Ltd.		Direct		31 Oct 2019	911,865
Brandes Investment Partners, L.P.		Direct		04 Oct 2019	1,244,035
Schroder Investment Management, Ltd.		Direct		04 Oct 2019	858,500
Schroder Investment Management, Ltd.		Direct		02 Oct 2019	0
Wellcome Trust Ltd		Direct		10 Sept 2019	0
Majedie Asset Management, Ltd.		Direct		09 Sept 2019	548,311
Sutherland (Martin)		Direct		05 Sept 2019	33,722
Sutherland (Martin)	Sold at price 2.58 per share.	Direct	40,989	05 Sept 2019	15,906
Easton (Joanne)		Direct		05 Sept 2019	2,791
Easton (Joanne)	Sold at price 2.58 per share.	Direct	3,290	05 Sept 2019	1,277

FTSE 1008,213.49+41.34(+0.51%)

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Insider transactions

Insider transactions reported - last two years

FTSE 100
8,213.49
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FTSE 250
20,164.54
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AIM
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GBP/USD
1.2546
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Bitcoin GBP
49,994.56
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