Insider	Transaction	Type	Value	Date	Shares
Vulpes Life Science Fund	Bought at price 0.05 per share.	Direct	76,180	19 Apr 2022	1,465,000
Vulpes Life Science Fund		Direct		30 Mar 2022	0
Vulpes Life Science Fund		Direct		28 Mar 2022	37
Dennis (Richard)		Direct		31 Dec 2021	0
Mc-Dowell (Roger Steven)		Direct		31 Dec 2021	0
Pearce (Christopher Donovan James)		Direct		31 Dec 2021	0
Pike (Ian H)		Direct		31 Dec 2021	0
Mc-Dowell (Roger Steven)	Bought at price 0.07 per share.	Direct	62,100	16 Apr 2021	900,000
Dennis (Richard)	Bought at price 0.07 per share.	Direct	43,125	13 Apr 2021	625,000
Vulpes Life Science Fund		Direct		31 Mar 2021	0
Helium Special Situations Fund		Direct		31 Mar 2021	2,800,000
Helium Special Situations Fund		Direct		31 Mar 2021	0
Pearce (Christopher Donovan James)		Direct		31 Mar 2021	0
Helium Special Situations Fund		Direct		26 Mar 2021	3,359,890
Helium Special Situations Fund		Direct		15 Jan 2021	752,373
Vulpes Life Science Fund		Direct		31 Dec 2020	0
Pearce (Christopher Donovan James)		Direct		31 Dec 2020	0
Pike (Ian H)		Direct		31 Dec 2020	0
Mc-Dowell (Roger Steven)		Direct		31 Dec 2020	0
Vulpes Life Science Fund	Bought at price 0.05 per share.	Direct	18,514	14 Sept 2020	363,037
Helium Special Situations Fund		Direct		24 Jul 2020	150,000
Vulpes Life Science Fund	Bought at price 0.05 per share.	Direct	4,999	03 Jul 2020	99,999
Vulpes Life Science Fund	Bought at price 0.05 per share.	Direct	3,000	01 Jul 2020	60,000
Vulpes Life Science Fund	Bought at price 0.05 per share.	Direct	5,000	30 Jun 2020	100,000
Helium Special Situations Fund		Direct		30 Apr 2020	4,457,013
Helium Special Situations Fund		Direct		09 Apr 2020	0
Vulpes Life Science Fund		Direct		09 Apr 2020	0
Pearce (Christopher Donovan James)		Direct		09 Apr 2020	0
Pearce (Christopher Donovan James)		Direct		03 Mar 2020	0
Pike (Ian H)		Direct		03 Mar 2020	0
Haigh (Jeremy)		Direct		03 Mar 2020	0
Helium Special Situations Fund		Direct		03 Mar 2020	0
Vulpes Life Science Fund		Direct		03 Mar 2020	0
Mc-Dowell (Roger Steven)		Direct		03 Mar 2020	0
Mc-Dowell (Roger Steven)		Direct		31 Dec 2019	0
Pearce (Christopher Donovan James)		Direct		31 Dec 2019	0
Pike (Ian H)		Direct		31 Dec 2019	0
Haigh (Jeremy)		Direct		31 Dec 2019	0
Haigh (Jeremy)		Direct		01 Apr 2019	0
Helium Special Situations Fund		Direct		01 Apr 2019	0
Mc-Dowell (Roger Steven)		Direct		01 Apr 2019	0
Pearce (Christopher Donovan James)		Direct		01 Apr 2019	0
Pike (Ian H)		Direct		01 Apr 2019	0
Vulpes Life Science Fund		Direct		01 Apr 2019	0
Haigh (Jeremy)		Direct		31 Dec 2018	0
Pearce (Christopher Donovan James)		Direct		31 Dec 2018	0
Pike (Ian H)		Direct		31 Dec 2018	0
Mc-Dowell (Roger Steven)		Direct		31 Dec 2018	0
Vulpes Life Science Fund	Bought at price 0.04 per share.	Direct	38,000	23 Nov 2018	1,000,000
Spreadex, Ltd.		Direct		23 Nov 2018	0
Vulpes Life Science Fund	Bought at price 0.04 per share.	Direct	19,500	22 Nov 2018	500,000
Vulpes Life Science Fund	Bought at price 0.04 per share.	Direct	19,500	19 Nov 2018	500,000
Vulpes Life Science Fund	Bought at price 0.04 per share.	Direct	19,500	16 Nov 2018	500,000
Vulpes Life Science Fund	Bought at price 0.05 per share.	Direct	51,000	12 Nov 2018	1,000,000
Vulpes Life Science Fund	Bought at price 0.04 per share.	Direct	12,244	08 Nov 2018	313,957
Vulpes Life Science Fund	Bought at price 0.05 per share.	Direct	9,581	10 Oct 2018	180,790
Vulpes Life Science Fund	Bought at price 0.05 per share.	Direct	5,300	09 Oct 2018	100,000
Vulpes Life Science Fund	Bought at price 0.05 per share.	Direct	23,966	08 Oct 2018	460,899
Vulpes Life Science Fund	Bought at price 0.05 per share.	Direct	2,808	05 Oct 2018	54,000
Vulpes Life Science Fund	Bought at price 0.05 per share.	Direct	1,040	02 Oct 2018	20,000
Vulpes Life Science Fund	Bought at price 0.05 per share.	Direct	47,351	28 Sept 2018	910,608
Vulpes Life Science Fund	Bought at price 0.05 per share.	Direct	4	27 Sept 2018	81
Vulpes Life Science Fund	Bought at price 0.05 per share.	Direct	4,002	20 Sept 2018	75,520
Vulpes Life Science Fund	Bought at price 0.05 per share.	Direct	31,282	11 Sept 2018	601,582
Vulpes Life Science Fund	Bought at price 0.05 per share.	Direct	25,500	13 Aug 2018	500,000
Vulpes Life Science Fund	Bought at price 0.05 per share.	Direct	23,963	13 Aug 2018	469,866
Vulpes Life Science Fund	Bought at price 0.05 per share.	Direct	72,800	07 Aug 2018	1,400,000
Vulpes Life Science Fund	Bought at price 0.05 per share.	Direct	17,056	01 Aug 2018	328,000
Vulpes Life Science Fund	Bought at price 0.04 per share.	Direct	20,475	27 Jul 2018	525,000
Vulpes Life Science Fund	Bought at price 0.05 per share.	Direct	6,136	27 Jul 2018	118,000
Vulpes Life Science Fund	Bought at price 0.04 per share.	Direct	6,840	25 Jul 2018	171,000
Vulpes Life Science Fund		Direct		03 Jul 2018	0
Mc-Dowell (Roger Steven)		Direct		03 Jul 2018	0
Dawson (William)		Direct		03 Jul 2018	0
Pearce (Christopher Donovan James)		Direct		03 Jul 2018	0
Haigh (Jeremy)		Direct		03 Jul 2018	0
Helium Special Situations Fund		Direct		03 Jul 2018	0
Haigh (Jeremy)		Direct		23 Apr 2018	0
Helium Special Situations Fund		Direct		23 Apr 2018	0
Mc-Dowell (Roger Steven)		Direct		23 Apr 2018	0
Vulpes Life Science Fund		Direct		23 Apr 2018	0
Pearce (Christopher Donovan James)		Direct		23 Apr 2018	0
Pike (Ian H)		Direct		23 Apr 2018	0
Dawson (William)		Direct		23 Apr 2018	0
Mc-Dowell (Roger Steven)	Sold at price 0.04 per share.	Direct	21,000	21 Mar 2018	500,000
Mc-Dowell (Roger Steven)	Bought at price 0.04 per share.	Direct	21,000	21 Mar 2018	500,000
Spreadex, Ltd.		Direct		07 Nov 2017	0
Vulpes Life Science Fund	Bought at price 0.04 per share.	Direct	800	06 Nov 2017	20,000
Vulpes Life Science Fund		Direct		25 Oct 2017	184,460
Vulpes Life Science Fund	Bought at price 0.04 per share.	Direct	2,925	24 Oct 2017	75,000
Vulpes Life Science Fund	Bought at price 0.04 per share.	Direct	4,785	20 Oct 2017	119,636
Vulpes Life Science Fund	Bought at price 0.04 per share.	Direct	7,530	19 Oct 2017	193,100
Spreadex, Ltd.		Direct		19 Oct 2017	0
Vulpes Life Science Fund	Bought at price 0.04 per share.	Direct	10,260	18 Oct 2017	256,520
Spreadex, Ltd.		Direct		29 Jun 2017	0
Vulpes Life Science Fund	Bought at price 0.07 per share.	Direct	6,325	10 May 2017	97,314
Vulpes Life Science Fund	Bought at price 0.07 per share.	Direct	6,500	09 May 2017	100,000
Vulpes Life Science Fund	Bought at price 0.07 per share.	Direct	6,500	08 May 2017	100,000
Vulpes Life Science Fund	Bought at price 0.07 per share.	Direct	72	05 May 2017	1,117
Vulpes Life Science Fund	Bought at price 0.06 per share.	Direct	15	03 May 2017	240
Vulpes Life Science Fund	Bought at price 0.07 per share.	Direct	6,500	02 May 2017	100,000
Vulpes Life Science Fund	Bought at price 0.07 per share.	Direct	86	02 May 2017	1,329
Vulpes Life Science Fund	Bought at price 0.07 per share.	Direct	6,500	27 Apr 2017	100,000
Lombard Odier Asset Management (Europe) Limited		Direct		27 Apr 2017	0
Pike (Ian H)		Direct		18 Apr 2017	323,891
Pearce (Christopher Donovan James)		Direct		27 Mar 2017	0
Staveley (Mark)		Direct		27 Mar 2017	0
Vulpes Life Science Fund		Direct		27 Mar 2017	0
Dawson (William)		Direct		27 Mar 2017	0
Haigh (Jeremy)		Direct		27 Mar 2017	0
Helium Special Situations Fund		Direct		27 Mar 2017	0
Henderson Group Plc		Direct		27 Mar 2017	0
Mc-Dowell (Roger Steven)		Direct		27 Mar 2017	0
Mc-Dowell (Roger Steven)		Direct		05 Jan 2017	0
Vulpes Life Science Fund		Direct		05 Jan 2017	0
Pearce (Christopher Donovan James)		Direct		05 Jan 2017	0
Staveley (Mark)		Direct		05 Jan 2017	0
Haigh (Jeremy)		Direct		05 Jan 2017	0
Helium Special Situations Fund		Direct		05 Jan 2017	0
Henderson Group Plc		Direct		05 Jan 2017	0
Dawson (William)		Direct		05 Jan 2017	0
Vulpes Life Science Fund	Bought at price 0.07 per share.	Direct	7,813	04 Jan 2017	105,590
Vulpes Life Science Fund	Bought at price 0.07 per share.	Direct	25,900	30 Dec 2016	350,000
Vulpes Life Science Fund	Bought at price 0.07 per share.	Direct	18,500	29 Dec 2016	250,000
Vulpes Life Science Fund		Direct		28 Dec 2016	265,000
Vulpes Life Science Fund	Bought at price 0.07 per share.	Direct	19,345	28 Dec 2016	265,000
Vulpes Life Science Fund		Direct		14 Dec 2016	16,400,000
Spreadex, Ltd.		Direct		09 Nov 2016	0
Mc-Dowell (Roger Steven)	Bought at price 0.06 per share.	Direct	126,000	04 Nov 2016	2,000,000
Haigh (Jeremy)	Bought at price 0.06 per share.	Direct	25,200	04 Nov 2016	400,000
Henderson Group Plc		Direct		04 Nov 2016	0
Spreadex, Ltd.		Direct		21 Sept 2016	20,000
Pearce (Christopher Donovan James)		Direct		30 Jun 2016	0
Staveley (Mark)		Direct		30 Jun 2016	0
Helium Special Situations Fund		Direct		30 Jun 2016	0
Dawson (William)		Direct		30 Jun 2016	0
Mc-Dowell (Roger Steven)		Direct		30 Jun 2016	0
Vulpes Life Science Fund		Direct		30 Jun 2016	0
Vulpes Life Science Fund		Direct		17 May 2016	0
Helium Special Situations Fund		Direct		17 May 2016	0
Pearce (Christopher Donovan James)		Direct		17 May 2016	0
Staveley (Mark)		Direct		17 May 2016	0
Mc-Dowell (Roger Steven)		Direct		17 May 2016	0
Dawson (William)		Direct		17 May 2016	0
Vulpes Life Science Fund		Direct		05 Jan 2016	25,000
Vulpes Life Science Fund		Direct		14 Dec 2015	0
Vulpes Life Science Fund		Direct		11 Dec 2015	100,000
Vulpes Life Science Fund	Bought at price 0.28 per share.	Direct	728,492	31 Jul 2015	2,592,500
Pearce (Christopher Donovan James)	Bought at price 0.28 per share.	Direct	507,360	31 Jul 2015	1,805,555
Spreadex, Ltd.		Direct		01 Jul 2015	605,321

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Insider transactions reported - last two years

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