Insider	Transaction	Type	Value	Date	Shares
Sofinnova Crossover I SLP		Direct		09 Aug 2022	1,332,230
Amer (Richard)	Sold at price 0.71 per share.	Direct	356,000	05 Aug 2022	500,000
Amer (Richard)	Exercise of Option at price 0.19 per share.	Direct	97,000	27 Jul 2022	500,000
Redmile Group, L.L.C.		Direct		08 Jun 2022	27,461,017
Sofinnova Crossover I SLP		Direct		07 Jun 2022	16,949,153
Wild (Sarah Gordon)	Bought at price 0.74 per share.	Direct	314,830	07 Jun 2022	423,729
Anson (Lisa)	Bought at price 0.74 per share.	Direct	25,186	07 Jun 2022	33,899
Griffiths (Jane Veronica)	Bought at price 0.74 per share.	Direct	62,966	07 Jun 2022	84,746
Polar Capital, L.L.P.		Direct		15 Dec 2021	0
Redmile Group, L.L.C.		Direct		15 Dec 2021	0
Sofinnova Crossover I SLP		Direct		15 Dec 2021	0
Presland (Peter Eric)		Direct		30 Sept 2021	0
Wild (Sarah Gordon)		Direct		30 Sept 2021	0
Anson (Lisa)		Direct		30 Sept 2021	0
Anson (Lisa)	Bought at price 0.75 per share.	Direct	66,785	22 Dec 2020	89,286
Anson (Lisa)	Bought at price 0.67 per share.	Direct	26,718	22 Dec 2020	39,998
Presland (Peter Eric)	Bought at price 0.75 per share.	Direct	20,477	22 Dec 2020	27,376
Redmile Group, L.L.C.		Direct		22 Dec 2020	41,136,548
Ross (Iain Gladstone)	Bought at price 0.75 per share.	Direct	26,277	22 Dec 2020	35,130
Sofinnova Crossover I SLP		Direct		22 Dec 2020	0
Wild (Sarah Gordon)	Bought at price 0.75 per share.	Direct	667,857	22 Dec 2020	892,858
Redmile Group, L.L.C.		Direct		01 Sept 2020	897,276
Redmile Group, L.L.C.		Direct		22 Jul 2020	0
Presland (Peter Eric)	Bought at price 0.31 per share.	Direct	36,843	30 Jun 2020	118,849
Ross (Iain Gladstone)	Bought at price 0.21 per share.	Direct	18,331	30 Jun 2020	86,881
Ross (Iain Gladstone)	Bought at price 0.24 per share.	Direct	12,741	30 Jun 2020	53,989
Ross (Iain Gladstone)	Bought at price 0.25 per share.	Direct	8,680	30 Jun 2020	35,000
Ross (Iain Gladstone)	Bought at price 0.28 per share.	Direct	11,399	30 Jun 2020	40,000
Redmile Group, L.L.C.		Direct		15 Jun 2020	474,401
Oddo BHF Asset Management SAS	Sold at price 0.20 per share.	Direct	1,899,450	30 Apr 2020	9,450,000
Redmile Group, L.L.C.		Direct		30 Apr 2020	64,554,271
Redmile Group, L.L.C.		Direct		09 Apr 2020	880,408
Redmile Group, L.L.C.	Bought at price 0.20 per share.	Direct	3,261,773	02 Apr 2020	16,473,605
Seneca Partners Ltd	Sold at price 0.20 per share.	Direct	3,123,005	02 Apr 2020	15,772,756
Redmile Group, L.L.C.	Bought at price 0.20 per share.	Direct	341,550	01 Apr 2020	1,725,000
Redmile Group, L.L.C.	Bought at price 0.20 per share.	Direct	162,141	31 Mar 2020	814,783
Redmile Group, L.L.C.		Direct		26 Mar 2020	0
Redmile Group, L.L.C.	Bought at price 0.18 per share.	Direct	587,828	23 Mar 2020	3,177,450
Seneca Partners Ltd		Direct		23 Mar 2020	13,824
Hopkinson (Christopher John)	Sold at price 0.18 per share.	Direct	564,250	23 Mar 2020	3,050,000
Redmile Group, L.L.C.	Bought at price 0.19 per share.	Direct	372,000	20 Mar 2020	2,000,000
Warnock (David)	Sold at price 0.19 per share.	Direct	372,000	20 Mar 2020	2,000,000
Hooker (Sarah)		Direct		19 Mar 2020	2,021,025
Kirschbaum (Bernhard Jurgen)		Direct		17 Mar 2020	0
Milne (Alexander)	Bought at price 0.18 per share.	Direct	54,300	17 Mar 2020	300,000
Presland (Peter Eric)		Direct		17 Mar 2020	0
Ross (Iain Gladstone)		Direct		17 Mar 2020	0
WG Partners LLP		Direct		17 Mar 2020	0
Moulton Goodies Ltd	Sold at price 0.20 per share.	Direct	14,699,783	16 Mar 2020	74,998,896
AXA Framlington Investment Management		Direct		16 Mar 2020	0
Milne (Alexander)	Bought at price 0.17 per share.	Direct	111,799	16 Mar 2020	650,000
Aviva Investors Global Services Limited	Sold at price 0.18 per share.	Direct	1,569,224	13 Mar 2020	8,528,394
Oddo BHF Asset Management SAS	Bought at price 0.18 per share.	Direct	1,738,800	13 Mar 2020	9,450,000
Redmile Group, L.L.C.		Direct		13 Mar 2020	74,998,896
Seneca Partners Ltd		Direct		13 Mar 2020	0
Moulton Goodies Ltd		Direct		09 Mar 2020	0
Redmile Group, L.L.C.		Direct		09 Mar 2020	0
Seneca Partners Ltd		Direct		09 Mar 2020	0
Aviva Investors Global Services Limited		Direct		09 Mar 2020	0
AXA Framlington Investment Management		Direct		09 Mar 2020	0
Hargreaves Lansdown Plc		Direct		09 Mar 2020	0
Redmile Group, L.L.C.		Direct		04 Mar 2020	0
Hopkinson (Christopher John)		Direct		31 Jan 2020	0
Aviva Investors Global Services Limited		Direct		22 Jan 2020	0
Moulton Goodies Ltd	Bought at price 0.07 per share.	Direct	3,434,032	22 Jan 2020	52,030,789
Blackmore (Paul)		Direct		20 Jan 2020	1,100,000
Hallahane (Bridget)		Direct		14 Jan 2020	0
Hallahane (Dennis William Patrick)		Direct		14 Jan 2020	0
Hallahane (Paulene)		Direct		14 Jan 2020	0
Hooker (Sarah)		Direct		14 Jan 2020	0
Moulton Goodies Ltd		Direct		14 Jan 2020	0
Richards (Thekla Angela)		Direct		14 Jan 2020	0
Edwards (Graham Henry)		Direct		13 Jan 2020	583,529
Kirschbaum (Bernhard Jurgen)		Direct		09 Jan 2020	0
Presland (Peter Eric)		Direct		09 Jan 2020	0
Ross (Iain Gladstone)		Direct		09 Jan 2020	0
Warnock (David)		Direct		09 Jan 2020	0
WG Partners LLP		Direct		09 Jan 2020	0
Mercia Technologies PLC	Sold at price 0.10 per share.	Direct	26,250	06 Jan 2020	250,000
Aviva Investors Global Services Limited		Direct		31 Dec 2019	130,424
AXA Framlington Investment Management		Direct		31 Dec 2019	0
Moulton Goodies Ltd		Direct		31 Dec 2019	0
Seneca Partners Ltd		Direct		31 Dec 2019	120,911
Aviva Investors Global Services Limited		Direct		06 Nov 2019	1,610,939
Kirschbaum (Bernhard Jurgen)		Direct		30 Sept 2019	0
Presland (Peter Eric)		Direct		30 Sept 2019	0
Ross (Iain Gladstone)		Direct		30 Sept 2019	0
Mead (James)	Exercise of Option at price 0.18 per share.	Direct	36,000	13 Feb 2019	200,000
Mead (James)	Exercise of Option at price 0.26 per share.	Direct	51,400	13 Feb 2019	200,000
Kirschbaum (Bernhard Jurgen)		Direct		30 Sept 2018	0
Molyneux (Norman James)		Direct		30 Sept 2018	0
Presland (Peter Eric)		Direct		30 Sept 2018	0
Ross (Iain Gladstone)		Direct		30 Sept 2018	0
Moulton Goodies Ltd		Direct		29 Aug 2018	0
Seneca Partners Ltd		Direct		29 Aug 2018	0
Aviva Investors Global Services Limited		Direct		29 Aug 2018	0
AXA Framlington Investment Management		Direct		29 Aug 2018	0
Blackmore (Paul)		Direct		29 Aug 2018	0
Edwards (Graham Henry)		Direct		29 Aug 2018	0
Hargreaves Lansdown Plc		Direct		29 Aug 2018	0
Ross (Iain Gladstone)	Bought at price 0.15 per share.	Direct	22,950	25 Apr 2018	150,000
Moulton Goodies Ltd		Direct		11 Apr 2018	4,318,107
Lanstead Capital LP		Direct		11 Apr 2018	9,625,000
Kirschbaum (Bernhard Jurgen)	Bought at price 0.28 per share.	Direct	14,050	27 Dec 2017	50,000
Presland (Peter Eric)	Bought at price 0.29 per share.	Direct	35,280	22 Dec 2017	120,000
Ross (Iain Gladstone)	Bought at price 0.28 per share.	Direct	28,662	22 Dec 2017	102,000
Lanstead Capital LP		Direct		20 Dec 2017	2,450,000
Blackmore (Paul)		Direct		12 Dec 2017	1,100,000
Blackmore (Paul)		Direct		30 Nov 2017	0
Ross (Iain Gladstone)	Bought at price 0.24 per share.	Direct	82,476	14 Nov 2017	348,000
Murray (Neil David)		Direct		03 Nov 2017	0
Moulton Goodies Ltd		Direct		18 Apr 2017	0
Seneca Partners Ltd		Direct		18 Apr 2017	0
Aviva Investors Global Services Limited		Direct		18 Apr 2017	0
AXA Framlington Investment Management		Direct		18 Apr 2017	0
Edwards (Graham Henry)		Direct		18 Apr 2017	0
Lanstead Capital LP		Direct		18 Apr 2017	0
Alderley Park Holdings, Ltd.		Direct		01 Mar 2017	690,000
Aviva Investors Global Services Limited		Direct		01 Mar 2017	3,922,912
Lanstead Capital LP		Direct		01 Mar 2017	0
Moulton (Jonathan Paul)		Direct		01 Mar 2017	9,998,850
Moulton Goodies Ltd		Direct		01 Mar 2017	0
Seneca Partners Ltd		Direct		28 Feb 2017	5,085,000
NW VCF HF LLP		Direct		16 Nov 2016	0
Seneca Partners Ltd		Direct		16 Nov 2016	0
Alderley Park Holdings, Ltd.		Direct		16 Nov 2016	0
Aviva Investors Global Services Limited		Direct		16 Nov 2016	0
AXA Framlington Investment Management		Direct		16 Nov 2016	0
Edwards (Graham Henry)		Direct		16 Nov 2016	0
Jackson (Peter)		Direct		16 Nov 2016	0
Moulton (Jonathan Paul)		Direct		16 Nov 2016	0
Armstrong (Frank Murdoch)		Direct		30 Sept 2016	0
Jackson (Peter)		Direct		30 Sept 2016	0
Lindsay (Derek)		Direct		30 Sept 2016	0
Mc-Partland (Peter)		Direct		30 Sept 2016	0
Molyneux (Norman James)		Direct		30 Sept 2016	0
Murray (Neil David)		Direct		30 Sept 2016	0
Alderley Park Holdings, Ltd.		Direct		21 Sept 2016	770,000
Aviva Investors Global Services Limited		Direct		19 Sept 2016	1,032,448
Aviva Investors Global Services Limited		Direct		14 Sept 2016	435,000
Aviva Investors Global Services Limited		Direct		12 Sept 2016	1,165,911
Aviva Investors Global Services Limited		Direct		15 Apr 2016	0
Seneca Partners Ltd		Direct		15 Apr 2016	4,451,365
Alderley Park Holdings, Ltd.		Direct		13 Apr 2016	2,572,143
Legal & General Investment Management, Ltd.		Direct		13 Apr 2016	0
AXA Framlington Investment Management		Direct		01 Feb 2016	0
Edwards (Graham Henry)		Direct		01 Feb 2016	0
Jackson (Peter)		Direct		01 Feb 2016	0
Lindsay (Derek)		Direct		01 Feb 2016	0
Moulton (Jonathan Paul)		Direct		01 Feb 2016	0

FTSE 1008,213.49+41.34(+0.51%)

FTSE 25020,164.54+112.21(+0.56%)

AIM771.53+3.42(+0.45%)

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Insider transactions

Insider transactions reported - last two years

FTSE 100
8,213.49
+41.34(+0.51%)

FTSE 250
20,164.54
+112.21(+0.56%)

AIM
771.53
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GBP/EUR
1.1652
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GBP/USD
1.2546
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Bitcoin GBP
50,683.23
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