Insider	Transaction	Type	Value	Date	Shares
The Wales Life Sciences Investment Fund LP		Direct		02 Sept 2022	0
Obotritia Capital KGaA		Direct		02 Sept 2022	0
Octopus Investments Nominees Ltd		Direct		02 Sept 2022	0
Rosetta Capital V GP Ltd.		Direct		02 Sept 2022	0
Ross (Iain)	Bought at price 0.31 per share.	Direct	31,100	02 Sept 2022	100,000
Griffiths (Richard Ian)		Direct		02 Sept 2022	0
Owen (Michael John)		Direct		11 Aug 2022	0
Staehelin (Barbara)		Direct		11 Aug 2022	0
Walton (Martin)		Direct		11 Aug 2022	0
Isted (Catherine)	Bought at price 0.38 per share.	Direct	19,000	13 Jul 2022	50,000
Staehelin (Barbara)	Bought at price 0.36 per share.	Direct	45,339	12 Jul 2022	127,000
Staehelin (Barbara)		Direct		31 Mar 2022	0
Walton (Martin)		Direct		31 Mar 2022	0
Owen (Michael John)		Direct		31 Mar 2022	0
Spreadex, Ltd.		Direct		21 Mar 2022	0
Spreadex, Ltd.		Direct		10 Feb 2022	0
Griffiths (Richard Ian)		Direct		10 Feb 2022	2,001,205
Obotritia Capital KGaA		Direct		08 Feb 2022	225,000
Obotritia Capital KGaA		Direct		07 Feb 2022	839,386
Obotritia Capital KGaA		Direct		02 Feb 2022	579,228
Staehelin (Barbara)	Bought at price 1.59 per share.	Direct	68,370	20 Oct 2021	43,000
Owen (Michael John)		Direct		31 Jul 2021	0
Corn (Timothy Henry)		Direct		31 Jul 2021	0
Evans (Mark)		Direct		31 Jul 2021	0
Evans (Sir Christopher)		Direct		31 Jul 2021	0
Hellebo (Olav)		Direct		31 Jul 2021	0
The Wales Life Sciences Investment Fund LP		Direct		07 Jul 2021	0
Obotritia Capital KGaA		Direct		07 Jul 2021	0
Octopus Investments Nominees Ltd		Direct		07 Jul 2021	0
Rosetta Capital V GP Ltd.		Direct		07 Jul 2021	0
Griffiths (Richard Ian)		Direct		07 Jul 2021	0
Griffiths (Richard Ian)		Direct		15 Jun 2021	485,358
Octopus Investments Nominees Ltd		Direct		04 Jun 2021	475,000
Owen (Michael John)		Direct		31 Mar 2021	0
Corn (Timothy Henry)		Direct		31 Mar 2021	0
Hellebo (Olav)		Direct		31 Mar 2021	0
Hunt (Michael Elliott)		Direct		31 Mar 2021	0
Evans (Mark)		Direct		31 Mar 2021	0
Evans (Sir Christopher)		Direct		31 Mar 2021	0
Griffiths (Richard Ian)		Direct		29 Mar 2021	221,000
Rosetta Capital V GP Ltd.		Direct		15 Mar 2021	0
Griffiths (Richard Ian)		Direct		12 Mar 2021	986,500
Obotritia Capital KGaA		Direct		16 Dec 2020	0
Obotritia Capital KGaA		Direct		15 Dec 2020	1,142,857
Octopus Investments Nominees Ltd		Direct		15 Dec 2020	0
Owen (Michael John)	Bought at price 0.94 per share.	Direct	6,727	15 Dec 2020	7,142
Evans (Mark)	Bought at price 0.94 per share.	Direct	282,599	15 Dec 2020	299,999
Evans (Sir Christopher)	Bought at price 0.94 per share.	Direct	1,345,713	15 Dec 2020	1,428,571
Griffiths (Richard Ian)		Direct		15 Dec 2020	0
Hellebo (Olav)	Bought at price 0.94 per share.	Direct	26,913	15 Dec 2020	28,571
Schroders Plc		Direct		15 Dec 2020	0
The Wales Life Sciences Investment Fund LP		Direct		15 Dec 2020	101
Corn (Timothy Henry)	Bought at price 0.94 per share.	Direct	6,727	15 Dec 2020	7,142
Hunt (Michael Elliott)	Bought at price 0.94 per share.	Direct	20,185	15 Dec 2020	21,428
Schroders Plc		Direct		14 Dec 2020	0
Hunt (Michael Elliott)		Direct		24 Nov 2020	0
Obotritia Capital KGaA		Direct		24 Nov 2020	0
Owen (Michael John)		Direct		24 Nov 2020	0
Evans (Mark)		Direct		24 Nov 2020	0
Evans (Sir Christopher)		Direct		24 Nov 2020	0
Hellebo (Olav)		Direct		24 Nov 2020	0
Corn (Timothy Henry)		Direct		24 Nov 2020	0
Obotritia Capital KGaA		Direct		13 Aug 2020	0
Schroders Plc		Direct		13 Aug 2020	0
The Wales Life Sciences Investment Fund LP		Direct		13 Aug 2020	0
Owen (Michael John)		Direct		31 Mar 2020	0
Berriman (John Edward)		Direct		31 Mar 2020	0
Cartmell (Simon Christopher)		Direct		31 Mar 2020	0
Corn (Timothy Henry)		Direct		31 Mar 2020	0
Hunt (Michael Elliott)		Direct		31 Mar 2020	0
Evans (Sir Christopher)		Direct		31 Mar 2020	0
Hellebo (Olav)		Direct		31 Mar 2020	0
Obotritia Capital KGaA		Direct		11 Feb 2020	250,500
Obotritia Capital KGaA		Direct		05 Feb 2020	0
Link Fund Solutions, Ltd.		Direct		05 Feb 2020	5,226,257
Woodford Investment Management LLP		Direct		16 Dec 2019	5,277,900
Schroders Plc		Direct		13 Dec 2019	0
Woodford Investment Management LLP		Direct		15 Oct 2019	5,226,257
Link Fund Solutions, Ltd.		Direct		15 Oct 2019	0
The Wales Life Sciences Investment Fund LP		Direct		02 Aug 2019	0
Woodford Investment Management LLP		Direct		02 Aug 2019	0
Woodford Investment Management LLP		Direct		01 Aug 2019	0
Hunt (Michael Elliott)		Direct		08 Jul 2019	0
Evans (Sir Christopher)		Direct		08 Jul 2019	0
Hellebo (Olav)		Direct		08 Jul 2019	0
Berriman (John Edward)		Direct		08 Jul 2019	0
Cartmell (Simon Christopher)		Direct		08 Jul 2019	0
Corn (Timothy Henry)		Direct		08 Jul 2019	0
Owen (Michael John)		Direct		08 Jul 2019	0
Woodford Investment Management LLP		Direct		05 Jul 2019	494,672
Woodford Investment Management LLP		Direct		17 Jun 2019	229,238
Grimster (Sharon)	Exercise of Option at price 1.30 per share.	Direct	51,987	09 May 2019	39,960
Grimster (Sharon)	Sold at price 3.47 per share.	Direct	138,821	09 May 2019	39,960
Corteling (Randolph)	Exercise of Option at price 1.30 per share.	Direct	33,607	09 May 2019	25,832
Corteling (Randolph)	Sold at price 3.47 per share.	Direct	89,740	09 May 2019	25,832
Evans (Sir Christopher)	Bought at price 2.98 per share.	Direct	29,760	18 Apr 2019	10,000
Griffiths (Richard Ian)		Direct		12 Apr 2019	440,000
Hunt (Michael Elliott)	Exercise of Option at price 1.31 per share.	Direct	4,549	12 Apr 2019	3,478
Hunt (Michael Elliott)	Sold at price 3.23 per share.	Direct	3,192	12 Apr 2019	988
Evans (Sir Christopher)	Bought at price 2.90 per share.	Direct	13,041	11 Apr 2019	4,500
Owen (Michael John)	Bought at price 3.08 per share.	Direct	13,054	11 Apr 2019	4,237
Berriman (John Edward)	Bought at price 2.94 per share.	Direct	234,960	11 Apr 2019	80,000
Cartmell (Simon Christopher)	Bought at price 2.95 per share.	Direct	22,886	11 Apr 2019	7,758
Berriman (John Edward)		Direct		31 Mar 2019	0
Cartmell (Simon Christopher)		Direct		31 Mar 2019	0
Corn (Timothy Henry)		Direct		31 Mar 2019	0
Evans (Sir Christopher)		Direct		31 Mar 2019	0
Hellebo (Olav)		Direct		31 Mar 2019	0
Hunt (Michael Elliott)		Direct		31 Mar 2019	0
Griffiths (Richard Ian)		Direct		05 Mar 2019	0
Invesco Limited		Direct		04 Mar 2019	3,132,955
Mortazavi (Ali)		Direct		04 Mar 2019	0
Invesco Limited		Direct		01 Mar 2019	637,163
Hunt (Michael Elliott)	Bought at price 0.88 per share.	Direct	6,536	27 Sept 2018	7,462
Hellebo (Olav)	Bought at price 0.88 per share.	Direct	13,083	27 Sept 2018	14,936
Evans (Sir Christopher)		Direct		19 Jul 2018	0
Hellebo (Olav)		Direct		19 Jul 2018	0
Hunt (Michael Elliott)		Direct		19 Jul 2018	0
Berriman (John Edward)		Direct		19 Jul 2018	0
Cartmell (Simon Christopher)		Direct		19 Jul 2018	0
Corn (Timothy Henry)		Direct		19 Jul 2018	0
Invesco Limited		Direct		17 Jul 2018	0
Woodford Investment Management LLP		Direct		17 Jul 2018	0
The Wales Life Sciences Investment Fund LP		Direct		17 Jul 2018	0
Invesco Limited		Direct		13 Jul 2018	827,023
Aviva Plc		Direct		13 Jul 2018	805,940
Aviva Plc		Direct		12 Jul 2018	278,744
Aviva Plc		Direct		11 Jul 2018	0
Invesco Limited		Direct		24 Jan 2018	0
Invesco Limited		Direct		18 Jul 2017	0
Aviva Plc		Direct		18 Jul 2017	0
The Wales Life Sciences Investment Fund LP		Direct		18 Jul 2017	0
Woodford Investment Management LLP		Direct		18 Jul 2017	0
Berriman (John Edward)		Direct		31 Mar 2017	0
Cartmell (Simon Christopher)		Direct		31 Mar 2017	0
Corn (Timothy Henry)		Direct		31 Mar 2017	0
Evans (Sir Christopher)		Direct		31 Mar 2017	0
Harper (Paul Bernard)		Direct		31 Mar 2017	0
Hellebo (Olav)		Direct		31 Mar 2017	0
Hunt (Michael Elliott)		Direct		31 Mar 2017	0
Hunt (Michael Elliott)	Bought at price 0.04 per share.	Direct	9,500	07 Feb 2017	250,000
Hellebo (Olav)	Bought at price 0.04 per share.	Direct	13,172	14 Dec 2016	346,644
Aviva Plc		Direct		03 Oct 2016	19,746,163
Berriman (John Edward)		Direct		31 Mar 2016	0
Cartmell (Simon Christopher)		Direct		31 Mar 2016	0
Corn (Timothy Henry)		Direct		31 Mar 2016	0
Evans (Sir Christopher)		Direct		31 Mar 2016	0
Harper (Paul Bernard)		Direct		31 Mar 2016	0
Hellebo (Olav)		Direct		31 Mar 2016	0
Hunt (Michael Elliott)		Direct		31 Mar 2016	0

FTSE 1007,848.45+0.46(+0.01%)

FTSE 25019,326.03-14.11(-0.07%)

AIM742.75-0.37(-0.05%)

GBP/EUR1.1684+0.0017(+0.15%)

GBP/USD1.2451-0.0006(-0.05%)

Bitcoin GBP50,186.73-235.48(-0.47%)

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Insider transactions

Insider transactions reported - last two years

FTSE 100
7,848.45
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FTSE 250
19,326.03
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AIM
742.75
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GBP/EUR
1.1684
+0.0017(+0.15%)

GBP/USD
1.2451
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Bitcoin GBP
50,186.73
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