Insider	Transaction	Type	Value	Date	Shares
Soci�t� G�n�rale S.A		Direct		06 Sept 2021	132,293
Soci�t� G�n�rale S.A		Direct		01 Sept 2021	90,027
Quested (Robert)		Direct		30 Jul 2021	610,000
Soci�t� G�n�rale S.A		Direct		30 Jul 2021	3,206,635
Lombard Odier Asset Management (Europe) Ltd		Direct		29 Apr 2021	1,377,041
Lombard Odier Asset Management (Europe) Ltd		Direct		28 Apr 2021	276,183
Lemus (David)	Bought at price 7.70 per share.	Direct	5,012	16 Apr 2021	651
Romano (Steven)	Bought at price 7.70 per share.	Direct	100,046	16 Apr 2021	12,993
Rothera (Mark A)	Bought at price 7.70 per share.	Direct	140,055	16 Apr 2021	18,189
Tooman (Craig A)	Bought at price 7.70 per share.	Direct	200,092	16 Apr 2021	25,986
Davidson (Michael)	Bought at price 7.70 per share.	Direct	100,046	16 Apr 2021	12,993
Griffiths (Richard Ian)		Direct		23 Feb 2021	0
Astrazeneca Uk Limited		Direct		10 Feb 2021	0
Griffiths (Richard Ian)		Direct		10 Feb 2021	1,018,563
Keith (Robert N)		Direct		10 Feb 2021	20,000
Quested (Robert)		Direct		10 Feb 2021	240,000
Lombard Odier Asset Management (Europe) Ltd		Direct		08 Feb 2021	2,164,373
Lombard Odier Asset Management (Europe) Ltd		Direct		04 Jan 2021	4,167
Lombard Odier Asset Management (Europe) Ltd		Direct		31 Dec 2020	0
Lombard Odier Asset Management (Europe) Ltd		Direct		31 Dec 2020	0
Quested (Robert)		Direct		31 Dec 2020	0
Soci�t� G�n�rale S.A		Direct		31 Dec 2020	0
Cache Holdings Ltd.		Direct		31 Dec 2020	0
Cache Holdings Ltd.		Direct		31 Dec 2020	0
Keith (Robert N)		Direct		31 Dec 2020	0
Quested (Robert)		Direct		10 Dec 2020	944,138
Romano (Steven)		Direct		30 Nov 2020	4,500
Gray (Alistair William)	Bought at price 5.17 per share.	Direct	6,497	14 Oct 2020	1,258
Ede-Golightly (James Lawrence)	Bought at price 5.34 per share.	Direct	16,029	12 Oct 2020	3,000
Campion (Giles)	Bought at price 5.27 per share.	Direct	26,065	09 Oct 2020	4,945
Lemus (David)	Bought at price 5.22 per share.	Direct	6,522	09 Oct 2020	1,250
Ross (Iain)	Bought at price 5.30 per share.	Direct	51,704	08 Oct 2020	9,750
Griffiths (Richard Ian)		Direct		18 Sept 2020	398,893
Lombard Odier Asset Management (Europe) Ltd		Direct		04 Sept 2020	28,748
Lombard Odier Asset Management (Europe) Ltd		Direct		21 Jul 2020	77,302
Lombard Odier Asset Management (Europe) Ltd		Direct		20 Jul 2020	98,993
Lombard Odier Asset Management (Europe) Ltd		Direct		26 Jun 2020	267,059
Griffiths (Richard Ian)		Direct		26 Jun 2020	380,253
Keith (Robert N)		Direct		09 Jun 2020	0
Griffiths (Richard Ian)		Direct		01 Jun 2020	427,650
Ross (Iain)	Bought at price 5.79 per share.	Direct	91,466	28 May 2020	15,800
Quinn (Rob)	Sold at price 4.91 per share.	Direct	358,906	11 May 2020	73,112
Quinn (Rob)	Sold at price 5.30 per share.	Direct	84,540	07 May 2020	15,942
Quinn (Rob)	Exercise of Option at price 2.34 per share.	Direct	76,409	23 Apr 2020	32,584
Quinn (Rob)	Exercise of Option at price 1.05 per share.	Direct	59,237	23 Apr 2020	56,470
Astrazeneca Uk Limited		Direct		30 Mar 2020	1,636,106
Griffiths (Richard Ian)		Direct		30 Mar 2020	4,454,434
Lombard Odier Asset Management (Europe) Ltd		Direct		09 Mar 2020	760,945
Soci�t� G�n�rale S.A		Direct		17 Feb 2020	2,902,892
Soci�t� G�n�rale S.A		Direct		17 Jan 2020	825,314
Soci�t� G�n�rale S.A		Direct		09 Jan 2020	810,000
Soci�t� G�n�rale S.A		Direct		07 Jan 2020	547,500
Soci�t� G�n�rale S.A		Direct		06 Jan 2020	432,500
Soci�t� G�n�rale S.A		Direct		03 Jan 2020	2,158,535
Lemus (David)		Direct		31 Dec 2019	0
Lombard Odier Asset Management (Europe) Ltd		Direct		31 Dec 2019	0
Lombard Odier Asset Management (Europe) Ltd		Direct		31 Dec 2019	0
Quested (Robert)		Direct		31 Dec 2019	0
Quested (Robert)		Direct		31 Dec 2019	0
Romano (Steven)		Direct		31 Dec 2019	0
Ross (Iain)		Direct		31 Dec 2019	0
Soci�t� G�n�rale S.A		Direct		31 Dec 2019	0
Soci�t� G�n�rale S.A		Direct		31 Dec 2019	0
Cache Holdings Ltd.		Direct		31 Dec 2019	0
Cache Holdings Ltd.		Direct		31 Dec 2019	0
Gray (Alistair William)		Direct		31 Dec 2019	0
Griffiths (Richard Ian)		Direct		31 Dec 2019	0
Griffiths (Richard Ian)		Direct		31 Dec 2019	0
Keith (Robert N)		Direct		31 Dec 2019	0
Keith (Robert N)		Direct		31 Dec 2019	0
Keith (Robert N)		Direct		13 Nov 2019	27,447
Lemus (David)	Exercise of Option at price 0.06 per share.	Direct	100	10 Oct 2019	1,626
Lemus (David)	Bought at price 2.31 per share.	Direct	9,256	10 Oct 2019	4,000
Gray (Alistair William)	Exercise of Option at price 0.06 per share.	Direct	99	07 Oct 2019	1,626
Gray (Alistair William)	Bought at price 2.33 per share.	Direct	7,372	02 Oct 2019	3,171
Romano (Steven)	Bought at price 2.37 per share.	Direct	23,740	02 Oct 2019	10,000
Soci�t� G�n�rale S.A		Direct		02 Oct 2019	2,404,483
Ross (Iain)	Bought at price 2.31 per share.	Direct	57,750	30 Sept 2019	25,000
Quested (Robert)		Direct		06 Sept 2019	5,951,327
Soci�t� G�n�rale S.A		Direct		21 Aug 2019	771,909
Soci�t� G�n�rale S.A		Direct		31 Jul 2019	0
Lombard Odier Asset Management (Europe) Ltd		Direct		24 Jul 2019	69,377
Mortazavi (Ali)		Direct		24 Jul 2019	816
Quested (Robert)		Direct		24 Jul 2019	20,000
Cache Holdings Ltd.		Direct		24 Jul 2019	0
Spreadex, Ltd.		Direct		10 Jul 2019	40,020
Lombard Odier Asset Management (Europe) Ltd		Direct		21 Jun 2019	3,181,096
Lombard Odier Asset Management (Europe) Ltd		Direct		19 Jun 2019	4,200,632
Spreadex, Ltd.		Direct		19 Jun 2019	2,667,873
Invesco, Ltd.		Direct		19 Jun 2019	3,623,941
Aviva Investors Global Services Limited		Direct		17 Jun 2019	3,537,529
Invesco, Ltd.		Direct		17 Jun 2019	1,273,187
Quested (Robert)		Direct		17 Jun 2019	1,430,090
Aviva Investors Global Services Limited		Direct		02 Apr 2019	40,667
Aviva Investors Global Services Limited		Direct		28 Feb 2019	20,000
Aviva Investors Global Services Limited		Direct		25 Feb 2019	37,190
Aviva Investors Global Services Limited		Direct		31 Dec 2018	0
Gray (Alistair William)		Direct		31 Dec 2018	0
Griffiths (Richard Ian)		Direct		31 Dec 2018	0
ING Bank N.V.		Direct		31 Dec 2018	0
Invesco, Ltd.		Direct		31 Dec 2018	0
Keith (Robert N)		Direct		31 Dec 2018	0
Lombard Odier Asset Management (Europe) Ltd		Direct		31 Dec 2018	0
Mortazavi (Ali)		Direct		31 Dec 2018	0
Parker (Stephen Barry)		Direct		31 Dec 2018	0
Richards (Andrew)		Direct		31 Dec 2018	0
Woodford Investment Management LLP		Direct		31 Dec 2018	0
Mortazavi (Ali)		Direct		04 Oct 2018	961,785
Spreadex, Ltd.		Direct		24 Aug 2018	0
ING Bank N.V.		Direct		24 Aug 2018	1,823,666
ING Bank N.V.		Direct		21 Feb 2018	303,863
Keith (Robert N)		Direct		29 Jan 2018	27,447
Spreadex, Ltd.		Direct		25 Jan 2018	0
Lombard Odier Asset Management (Europe) Ltd		Direct		31 Dec 2017	0
Mortazavi (Ali)		Direct		31 Dec 2017	0
Parker (Stephen Barry)		Direct		31 Dec 2017	0
Richards (Andrew)		Direct		31 Dec 2017	0
Simpson Financial Ltd		Direct		31 Dec 2017	0
Woodford Investment Management LLP		Direct		31 Dec 2017	0
Aviva Investors Global Services Limited		Direct		31 Dec 2017	0
Gray (Alistair William)		Direct		31 Dec 2017	0
Griffiths (Richard Ian)		Direct		31 Dec 2017	0
ING Bank N.V.		Direct		31 Dec 2017	0
Invesco, Ltd.		Direct		31 Dec 2017	0
Keith (Robert N)		Direct		31 Dec 2017	0
Lombard Odier Asset Management (Europe) Ltd		Direct		23 Oct 2017	4,571
Spreadex, Ltd.		Direct		20 Oct 2017	0
Lombard Odier Asset Management (Europe) Ltd		Direct		18 Oct 2017	8,459
Lombard Odier Asset Management (Europe) Ltd		Direct		17 Oct 2017	0
Spreadex, Ltd.		Direct		27 Sept 2017	10,000
ING Bank N.V.		Direct		27 Sept 2017	450,000
ING Bank N.V.		Direct		26 Sept 2017	342,416
ING Bank N.V.		Direct		25 Sept 2017	503,371
Aviva Investors Global Services Limited		Direct		20 Sept 2017	631,625
Griffiths (Richard Ian)		Direct		20 Sept 2017	385,014
ING Bank N.V.		Direct		20 Sept 2017	0
Keith (Robert N)		Direct		20 Sept 2017	845,933
Spreadex, Ltd.		Direct		20 Sept 2017	0
Griffiths (Richard Ian)		Direct		15 Aug 2017	265,938
Gray (Alistair William)	Bought at price 1.72 per share.	Direct	6,614	02 Aug 2017	3,848
Richards (Andrew)	Bought at price 1.93 per share.	Direct	13,510	28 Jul 2017	7,000
Griffiths (Richard Ian)		Direct		27 Jul 2017	1,380,214
Griffiths (Richard Ian)		Direct		26 Jun 2017	2,159,175
Antisoma Plc		Direct		31 Dec 2016	0
Aviva Investors Global Services Limited		Direct		31 Dec 2016	0
Gartmore Investment Management Plc		Direct		31 Dec 2016	0
Griffiths (Richard Ian)		Direct		31 Dec 2016	0
Invesco, Ltd.		Direct		31 Dec 2016	0
Keith (Robert N)		Direct		31 Dec 2016	0
Mortazavi (Ali)		Direct		31 Dec 2016	0

FTSE 1008,213.49+41.34(+0.51%)

FTSE 25020,164.54+112.21(+0.56%)

AIM771.53+3.42(+0.45%)

GBP/EUR1.1652-0.0031(-0.26%)

GBP/USD1.2546+0.0013(+0.11%)

Bitcoin GBP50,161.08+2,838.04(+6.00%)

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Insider transactions

Insider transactions reported - last two years

FTSE 100
8,213.49
+41.34(+0.51%)

FTSE 250
20,164.54
+112.21(+0.56%)

AIM
771.53
+3.42(+0.45%)

GBP/EUR
1.1652
-0.0031(-0.26%)

GBP/USD
1.2546
+0.0013(+0.11%)

Bitcoin GBP
50,161.08
+2,838.04(+6.00%)