UK markets closed

Spectrum Pharmaceuticals, Inc. (SPPI)

NasdaqGS - NasdaqGS Real-time price. Currency in USD
Add to watchlist
0.8567-0.0033 (-0.38%)
As of 12:01PM EDT. Market open.
Sign in to post a message.
  • d
    dcaf7
    Paper of Chinese authors in Turkish journal about modification of Poziotinib molecule to make it less toxic,
    "Design, synthesis, and in vitro antitumor activity of 6-aryloxyl substituted quinazoline derivatives"
    https://journals.tubitak.gov.tr/cgi/viewcontent.cgi?article=3373&context=chem
  • r
    reppeptgs
    Tremendous spike in volume in last minutes of trade, bringing day's total to over 20 million. Why? I don't think it was options expiration...

    Sarge
  • d
    dcaf7
    New paper describing Poziotinib as a potentially effective drug for metastatic breast cancer with certain HER2 mutation, "Poziotinib inhibits HER2 mutant-driven therapeutic resistance and multi-organ
    metastasis in breast cancer". Too bad, basket trial is terminated.
    https://www.eurekalert.org/news-releases/956908
  • G
    Garth
    SPPI has been heavily shorted and it continues to be. That big dump is a deliberate attempt to keep the price down. No true investor or trader is going to dump that much shares on the market at once because they know that it will hurt the price of the stock.

    The great news here is that despite the large dump, the price didn't suffer that much. And, when buying pressure comes, they will have to cover for all these borrowed shares they dump which will drive the price a lot higher.
  • R
    Rex
    21mm shares traded today? Did someone blink?
  • d
    dcaf7
    Basket trial termination and Phase Transition Success Rates (PTSR). I've never heard about it.
    Cannot post a link. Title, "Pipeline Moves: Further study shot of three cancer assets reviewed after early phase terminations."
  • r
    reppeptgs
    Well, this was a good week. After all we’ve been through, it’s a bit of an adjustment!

    Let’s look at the numbers. Even losing a penny on Friday while the market surged, SPPI managed a gain of 8.61 cents (10.85%) to close at 0.88. It was a good week overall; take a look at the daily ranges – lows and highs each climbed every session!

    The market in general had a rare positive week. Every day was green except Wednesday, and that session wasn’t very red at all. The NAS surged 7.49%. It trimmed its loss on the year to 25.8%...and who would have ever thought that would be a good thing?

    The DOW trailed the NAS up just like it has down, but the gain was still a respectable 5.39%. It’s loss on the year was pared to 13.4%.

    BA contributed a little bit to the festivities as it gained 3.46% to close at $141.53. The loss on the year is still 29.7%.

    My bio indexes had a banner week. The BTK charged up 8.66%; the IBB would not be outdone, as it surged 9.57%; the XBI, though, took The Cup, as it rocketed up 13.97%. The conservative XLV was not so conservative as it charged 7.76%.

    The Russell 2000 was right up there with the winners, gaining an even 6%.

    Last June 4, SPPI closed at $3.90. The YoY loss is now down to “only” 77.4%. There is still a lot of ground to make up on this front.

    Here are the daily ranges from this week:

    M Holiday
    T 0.78-0.84
    W 0.80-0.87
    Th 0.83-0.91
    F 0.87-0.97

    And from last week:

    M 0.73-0.78
    T 0.74-0.80
    W 0.75-0.80
    Th 0.71-0.79
    F 0.76-0.82

    As badly as the market has performed of late, it was really nice to have a whole week (4 sessions worth) where there was no great meltdown. Many stocks that were high-fliers just a few months ago and have since come back down to earth, gained back some self-esteem.

    I don’t count SPPI in that group, but a gain of almost 11% is nothing to be sneezed at.

    I mentioned CRDF a couple weeks back. It had backed off from its highs, but this week it surged again, ending with a gain of 34.3%.

    Will this last? I would be stunned if it did.

    The realistic hope at this point is that this week put some distance between stock prices and the recent lows. When the market dips again, hopefully those recent lows will hold.

    For this weekend, we can feel a little smarter. That will have to be enough for now.

    Sarge
  • r
    reppeptgs
    SPPI is…doing what these days? Holding its own? Not falling apart?

    Let’s look at the numbers. SPPI was actually green in 3 out of 5 sessions last week. But the bad days definitely outweighed the good. At Friday’s close, the stock had lost 2.73 cents (3.32%) for a price of 0.7939. Which, overall, could have been worse.

    The market overall was pretty much a mine field. Monday was awful, and things never really recovered. The NAS lost 4.87% for the week. Its loss on the year is now…30.98%. And the year is not quite half over.

    The DOW did just a little worse than the NAS, as it lost 4.79%. It’s loss on the year is now 17.86%.

    BA actually had a good week, surging 7.72% to close at $136.80. In spite of that gain, it has still lost 32.05% year to date.

    My bio indexes actually held their own, for the most part. The BTK only lost 0.13%; the IBB lost 0.83%; the XBI actually managed a gain of 0.87%. The conservative XLV was NOT a safe haven, down 4.46%.

    The Russell was motliest of the crew, tumbling 7.48%!

    Last June 4, SPPI closed at $4.34. The YoY loss is now 81.7%. This might improve next week, as the comparison share price will fall to $3.90.

    Here are the daily ranges from this week:

    M 0.73-0.78
    T 0.74-0.80
    W 0.75-0.80
    Th 0.71-0.79
    F 0.76-0.82

    And from last week:

    M 0.78-0.87
    T 0.80-0.91
    W 0.85-0.94
    Th 0.88-0.92
    F 0.80-0.90

    Know where I am right now in this investment? Taking comfort that the current stock price is not threatening the 52-week low.

    The market right now is really a fight for survival. Forget about style points – just keep on keeping on.

    Happy Belated Father’s Day to all the Dads.

    Sarge
  • d
    dcaf7
    First complete response was reported in NSCLC patient with EGFR Ex20ins mutation. She is in cohort 5, 8 mg BID. "Since the first reevaluation (after 4 weeks of therapy), the treatment with poziotinib resulted to be remarkably effective, with a partial response (PR) subsequently confirmed in May and July 2021".
    https://www.frontiersin.org/articles/10.3389/fonc.2022.902967/full
  • d
    dcaf7
    Some changes made in Poziotinib phase 3 study:
    1. Treatment will start with 8mg BID right away, no initial 16 mg QD treatment.
    2. It looks like most patients according to inclusion criteria should have previous platinum and a checkpoint inhibitor (CPI) therapy. So, it is 3d line patients.
  • d
    dcaf7
    Basket trial, NCT04172597 is terminated, "A Study of Poziotinib in Patients With Epidermal Growth Factor Receptor (EGFR) or Human Epidermal Growth Factor Receptor 2 (HER2) Activating Mutations in Advanced Malignancies".
    Reason: Strategic business decision (unrelated to safety).
    Actual enrollment: 1 participant.
    They didn't even try. What a joke.
  • C
    Connor
    New trader watchlist was published by these guys and it featured SPPI. (http://traderspot.club)
  • j
    jos
    time to buy again ...won't be this low next 3 weeks
  • d
    dcaf7
    In today's presentation, Tom said that mPFS for Docetaxel in NSCLC with HER2 Ex20ins mutations is 3-4 months. To me, a target HR of 0.58 in their Poziotinib Phase 3 study looks too risky. I guess, it is what FDA wants to see and Spectrum agreed on that.
  • d
    dcaf7
    Investment analysts at Cantor Fitzgerald issued their FY2023 earnings per share estimates for Spectrum Pharmaceuticals in a research note issued on Monday, June 6th. Cantor Fitzgerald analyst anticipates that the biotechnology company will earn ($0.18) per share for the year.
    Not bad considering ($0.26) earnings per share for the last quarter.
  • r
    reppeptgs
    I’m beginning to reconsider my opinion on Fridays.

    Let’s look at the numbers. It truly wasn’t as bad as it feels right now. In fact, SPPI was only down one day this week – Friday. Until then, it was actually up about 9 cents. But Friday it lost 9.23 cents, and that turned the week red – by a whopping 0.46% (which is better than almost any other stock in the market did). The closing price was 0.8212.

    The broad market had yet another tough week. The NAS actually started green in the first two sessions, but then it fell off a cliff, ending down 5.6% for the week. The loss on the year now stands at 27.5%. And it looks like it will get worse before it gets better.

    The DOW, again, didn’t stink as much as the NAS, but it wasn’t much better, losing 4.58%. It’s loss on the year is now 13.73%.

    BA didn’t help the DOW, losing 8.8% to close at $126.99. Its loss on the year is now 36.9%. Not helping at all.

    My bio indexes did some serious stinking of their own. The BTK lost 5.29%; the IBB lost 5.17%; the XBI rather predictably led the losers, down 5.89%). The conservative XLV was the best of a motley bunch, down 3.34%.

    The Russell was pretty much in the middle of the pack, losing 4.39%.

    Last June 4, SPPI closed at $4.45. The YoY loss now stands at (drumroll) 81.5%!

    Here are the daily ranges from this week:

    M 0.78-0.87
    T 0.80-0.91
    W 0.85-0.94
    Th 0.88-0.92
    F 0.80-0.90

    And from last week:

    M Holiday
    T 0.73-0.77
    W 0.70-0.76
    Th 0.70-0.76
    F 0.75-0.85

    While Friday was disappointing, there was a lot of that going around in the market. I’ll take a loss of 2/5 of a penny on a week like this.

    While I do think SPPI held up relatively well, I can’t say it will do so indefinitely, absent significant news. But, if it does succumb to all the gravity going around in the market, I’ll likely add a few shares, just for bragging rights some day.

    I’ve done that with CRDF lately, adding a few handfuls of shares while it had a 1-handle. It’s done wonders for my average cost per share. And it made an impressive close Friday when the rest of the market was falling apart. The rally helped it close up 50.7% on the week.

    It’s a tough time to watch the market. As usual, I recommend music. Try this toe-tapper from ELO. I hope it brings a smile.

    Sarge
    Mr. Blue Sky
    www.youtube.com
  • G
    Garth
    @jos...there's a catalyst in September and one in November. Do really believe this will remain at these prices? Even in these terrible economic conditions SPPI will easily go over $2.
  • r
    reppeptgs
    I’m still not crazy about Wednesdays. But some Fridays can be fun.

    Let’s look at the numbers. SPPI has been foundering of late, giving me concern that the stock might re-visit its lows from late January and early February. But an 8.5% gain Thursday, followed by an additional 8.62% Friday propelled it to trade higher than it had in 3 weeks. When the dust settled, the stock gained 12.16% on the week, closing at 83 cents per share.

    The broad market generally had a tough week, with one interesting “local” twist. The NAS was actually green heading into Friday, but Friday was deeply red, and the index ended down 0.97% for the week. The loss on the year now stands at 23.2%. Which is not as bad as the last time I reported on May 21. Scary.

    The DOW didn’t move as much as the NAS this week, but ended up in about the same place, down 0.94%. It’s loss on the year is now 9.58%.

    BA had a nice gain of 5.3%. But that only improved its loss on the year to 30.8%. Still a lot of catching up to do.

    Here’s where it gets interesting. My bio indexes this week tended to favor the “risk on” stocks. The BTK lost 2.57%; the IBB was right with its bigger sibling, down 2.51%; the XBI, though the riskiest of ETF’s, actually ended green (granted it was only 0.17%). The conservative XLV was the biggest loser on the week, down 3.13%. Very strange in such a tumultuous time.

    The Russell held its own this week, managing a small gain of 0.25%. Again, risk on.

    Last June 4, SPPI closed at $3.82. The YoY loss now stands at 78.3%.

    Here are the daily ranges from this week:

    M Holiday
    T 0.73-0.77
    W 0.70-0.76
    Th 0.70-0.76 (sic)
    F 0.75-0.85

    And from last week:

    M 0.72-0.78
    T 0.69-0.74
    W 0.69-0.73
    Th 0.70-0.74
    F 0.69-0.76

    This is not a time to be optimistic about SPPI or any stock that has all costs and no income. Without significant news like an FDA approval, this stock will be doing well to hold its own.

    That being said, there is something to be said for holding one’s own in such times.

    I WAS encouraged that the stock did not challenge its low of 60 cents a share from 4 months ago. The sentiment about the stock seems to be turning a corner…again.

    We watch and we wait. Almost patiently.

    Sarge
  • d
    dcaf7
  • D
    DeliverUsFromEvil
    How much does Hanmi buyout SPPI for?