Insider	Transaction	Type	Value	Date	Shares
Jupiter Asset Management Ltd		Direct		31 Aug 2022	40,401
AOP Orphan International AG		Direct		08 Aug 2022	0
Jupiter Asset Management Ltd		Direct		08 Aug 2022	0
W. Health L.P.		Direct		08 Aug 2022	0
W. Health L.P.		Direct		05 Aug 2022	0
AOP Orphan International AG		Direct		05 Aug 2022	41,195,246
AOP Orphan International AG		Direct		21 Jun 2022	0
W. Health L.P.		Direct		21 Jun 2022	0
Schweiger (Christian)		Direct		31 Dec 2021	0
Hasler (Hans Peter)		Direct		31 Dec 2021	0
Llewellyn-Davies (Peter)		Direct		31 Dec 2021	0
Watts (Timothy William)		Direct		31 Dec 2021	0
Lundstrom (Anders)	Bought at price 0.61 per share.	Direct	6,100	20 Aug 2021	10,000
AOP Orphan International AG		Direct		11 Jun 2021	0
Jupiter Asset Management Ltd		Direct		11 Jun 2021	0
Sterling Investments Management Ltd		Direct		11 Jun 2021	0
W. Health L.P.		Direct		11 Jun 2021	0
W. Health L.P.		Direct		28 Apr 2021	0
AOP Orphan International AG		Direct		28 Apr 2021	0
Jupiter Asset Management Ltd		Direct		28 Apr 2021	0
AOP Orphan International AG		Direct		19 Mar 2021	15,801,525
Jupiter Asset Management Ltd		Direct		19 Mar 2021	7,991,854
Schweiger (Christian)	Bought at price 0.42 per share.	Direct	541,332	19 Mar 2021	1,301,280
Schweiger (Christian)		Direct		19 Mar 2021	262,697
Universities Superannuation Scheme Ltd (Uss)		Direct		19 Mar 2021	340,000
W. Health L.P.		Direct		19 Mar 2021	7,639
Watts (Timothy William)	Bought at price 0.42 per share.	Direct	416,000	19 Mar 2021	1,000,000
Universities Superannuation Scheme Ltd (Uss)		Direct		12 Mar 2021	311,127
Hasler (Hans Peter)	Bought at price 0.53 per share.	Direct	105,200	05 Mar 2021	200,000
Hasler (Hans Peter)	Bought at price 0.52 per share.	Direct	103,200	03 Mar 2021	200,000
Hasler (Hans Peter)	Bought at price 0.81 per share.	Direct	80,600	20 Jan 2021	100,000
Watts (Timothy William)	Bought at price 0.82 per share.	Direct	81,800	19 Jan 2021	100,000
Watts (Timothy William)		Direct		31 Dec 2020	0
Schweiger (Christian)		Direct		31 Dec 2020	0
Sterritt (Carl Andrew)		Direct		31 Dec 2020	0
Llewellyn-Davies (Peter)		Direct		31 Dec 2020	0
Sterritt (Carl Andrew)		Direct		16 Dec 2020	4,717,506
Watts (Timothy William)	Bought at price 0.93 per share.	Direct	92,600	11 Dec 2020	100,000
Sterritt (Carl Andrew)		Direct		25 Nov 2020	1,992,855
MaRu AG		Direct		20 May 2020	0
Schweiger (Christian)		Direct		20 May 2020	0
Sterritt (Carl Andrew)		Direct		20 May 2020	0
Universities Superannuation Scheme Ltd (Uss)		Direct		20 May 2020	0
W. Health L.P.		Direct		20 May 2020	0
AOP Orphan International AG		Direct		20 May 2020	0
Jupiter Asset Management Ltd		Direct		20 May 2020	0
Watts (Timothy William)		Direct		27 Apr 2020	0
Griffiths (Richard)		Direct		19 Feb 2020	1,164,388
Karis (James M)		Direct		31 Dec 2019	0
Llewellyn-Davies (Peter)		Direct		31 Dec 2019	0
Sterritt (Carl Andrew)		Direct		31 Dec 2019	0
Griffiths (Richard)		Direct		28 Nov 2019	2,214,260
Karis (James M)	Bought at price 2.15 per share.	Direct	160,950	13 Aug 2019	75,000
Sampson (Mark Raymond)	Bought at price 1.12 per share.	Direct	25,665	25 Apr 2019	22,875
Sampson (Mark Raymond)	Bought at price 1.17 per share.	Direct	25,877	25 Apr 2019	22,042
Sterritt (Carl Andrew)	Exercise of Option at price 0.03 per share.	Direct	3,215	16 Apr 2019	123,690
Karis (James M)	Bought at price 1.06 per share.	Direct	4,228	16 Apr 2019	4,000
Karis (James M)	Bought at price 1.07 per share.	Direct	49,404	15 Apr 2019	46,000
Griffiths (Richard)		Direct		09 Apr 2019	1,050,000
Griffiths (Richard)		Direct		02 Apr 2019	0
MaRu AG		Direct		02 Apr 2019	0
Schweiger (Christian)		Direct		02 Apr 2019	0
Sterritt (Carl Andrew)		Direct		02 Apr 2019	0
Universities Superannuation Scheme Ltd (Uss)		Direct		02 Apr 2019	0
W. Health L.P.		Direct		02 Apr 2019	0
Sterritt (Carl Andrew)		Direct		31 Dec 2018	0
Karis (James M)		Direct		31 Dec 2018	0
Llewellyn-Davies (Peter)		Direct		31 Dec 2018	0
Griffiths (Richard)		Direct		09 Nov 2018	0
MaRu AG		Direct		09 Nov 2018	0
Schweiger (Christian)		Direct		09 Nov 2018	0
Sterritt (Carl Andrew)		Direct		09 Nov 2018	0
Universities Superannuation Scheme Ltd (Uss)		Direct		09 Nov 2018	0
W. Health L.P.		Direct		09 Nov 2018	0
Spreadex, Ltd.		Direct		08 Nov 2018	2,634,260
Griffiths (Richard)		Direct		08 Nov 2018	0
Spreadex, Ltd.		Direct		25 Sept 2018	0
Sterritt (Carl Andrew)	Bought at price 0.45 per share.	Direct	39,264	21 Sept 2018	88,235
Spreadex, Ltd.		Direct		19 Sept 2018	873,006
MaRu AG		Direct		09 Jul 2018	0
Schweiger (Christian)		Direct		09 Jul 2018	0
Spreadex, Ltd.		Direct		09 Jul 2018	0
Sterritt (Carl Andrew)		Direct		09 Jul 2018	0
Universities Superannuation Scheme Ltd (Uss)		Direct		09 Jul 2018	0
W. Health L.P.		Direct		09 Jul 2018	0
JPMorgan Asset Management U.K. Limited		Direct		09 Jul 2018	0
IRORPH GmbH		Direct		03 Jul 2018	12,527,438
MaRu AG		Direct		03 Jul 2018	0
Spreadex, Ltd.		Direct		01 May 2018	0
Schweiger (Christian)		Direct		10 Apr 2018	0
Sterritt (Carl Andrew)		Direct		10 Apr 2018	0
Universities Superannuation Scheme Ltd (Uss)		Direct		10 Apr 2018	0
W. Health L.P.		Direct		10 Apr 2018	0
IRORPH GmbH		Direct		10 Apr 2018	0
JPMorgan Asset Management U.K. Limited		Direct		10 Apr 2018	0
Estell (Joanne Elizabeth)		Direct		31 Dec 2017	0
Heath (Andrew John William)		Direct		31 Dec 2017	0
Jones (Richard CM)		Direct		31 Dec 2017	0
Karis (James M)		Direct		31 Dec 2017	0
Llewellyn-Davies (Peter)		Direct		31 Dec 2017	0
Sterritt (Carl Andrew)		Direct		31 Dec 2017	0
Aviva Investors Global Services Limited		Direct		07 Jul 2017	511,896
JPMorgan Asset Management U.K. Limited		Direct		30 Jun 2017	2,238,846
Estell (Joanne Elizabeth)	Bought at price 1.94 per share.	Direct	38,780	28 Jun 2017	20,000
Heath (Andrew John William)	Bought at price 1.94 per share.	Direct	6,464	28 Jun 2017	3,334
Karis (James M)	Bought at price 1.94 per share.	Direct	71,097	28 Jun 2017	36,667
Llewellyn-Davies (Peter)	Bought at price 1.94 per share.	Direct	19,390	28 Jun 2017	10,000
Sterritt (Carl Andrew)	Bought at price 1.94 per share.	Direct	25,854	28 Jun 2017	13,334
W. Health L.P.		Direct		28 Jun 2017	1,945,640
Schweiger (Christian)		Direct		03 Apr 2017	0
Sterritt (Carl Andrew)		Direct		03 Apr 2017	0
W. Health L.P.		Direct		03 Apr 2017	0
IRORPH GmbH		Direct		03 Apr 2017	0
JPMorgan Asset Management U.K. Limited		Direct		03 Apr 2017	0
Heath (Andrew John William)		Direct		31 Dec 2016	0
Jones (Richard CM)		Direct		31 Dec 2016	0
Aviva Investors Global Services Limited		Direct		13 Jun 2016	0
IRORPH GmbH		Direct		13 Jun 2016	0
JPMorgan Asset Management U.K. Limited		Direct		13 Jun 2016	0
Schweiger (Christian)		Direct		13 Jun 2016	0
Sterritt (Carl Andrew)		Direct		13 Jun 2016	0
W. Health L.P.		Direct		13 Jun 2016	0
Schweiger (Christian)		Direct		26 Feb 2016	0
Schweiger (Christian)		Direct		26 Feb 2016	0
Schweiger (Christian)		Direct		26 Feb 2016	0
Sterritt (Carl Andrew)		Direct		26 Feb 2016	0
Sterritt (Carl Andrew)		Direct		26 Feb 2016	0
Sterritt (Carl Andrew)		Direct		26 Feb 2016	0
W. Health L.P.		Direct		26 Feb 2016	0
W. Health L.P.		Direct		26 Feb 2016	0
W. Health L.P.		Direct		26 Feb 2016	0
Aviva Investors Global Services Limited		Direct		26 Feb 2016	0
Aviva Investors Global Services Limited		Direct		26 Feb 2016	0
Aviva Investors Global Services Limited		Direct		26 Feb 2016	0
Heath (Andrew John William)		Direct		26 Feb 2016	0
IRORPH GmbH		Direct		26 Feb 2016	0
IRORPH GmbH		Direct		26 Feb 2016	0
IRORPH GmbH		Direct		26 Feb 2016	0
Jones (Richard CM)		Direct		26 Feb 2016	0
JPMorgan Asset Management U.K. Limited		Direct		26 Feb 2016	0
JPMorgan Asset Management U.K. Limited		Direct		26 Feb 2016	0
JPMorgan Asset Management U.K. Limited		Direct		26 Feb 2016	0

FTSE 1008,170.96+23.93(+0.29%)

FTSE 25020,041.65-43.14(-0.21%)

AIM761.78-1.55(-0.20%)

GBP/EUR1.1708-0.0004(-0.03%)

GBP/USD1.2519-0.0043(-0.34%)

Bitcoin GBP50,119.69-539.11(-1.06%)

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Insider transactions

Insider transactions reported - last two years

FTSE 100
8,170.96
+23.93(+0.29%)

FTSE 250
20,041.65
-43.14(-0.21%)

AIM
761.78
-1.55(-0.20%)

GBP/EUR
1.1708
-0.0004(-0.03%)

GBP/USD
1.2519
-0.0043(-0.34%)

Bitcoin GBP
50,119.69
-539.11(-1.06%)