0.58%	% of shares held by all insiders
38.80%	% of shares held by institutions
39.02%	% of float held by institutions
209	Number of institutions holding shares

Holder	Shares	Date reported	% out	Value
State Street Corporation	8,486,301	30 Mar 2021	6.94%	51,342,121
Vanguard Group, Inc. (The)	5,477,693	30 Mar 2021	4.48%	33,140,042
Blackrock Inc.	5,417,916	30 Mar 2021	4.43%	32,778,391
Geode Capital Management, LLC	1,438,299	30 Mar 2021	1.18%	8,701,708
Susquehanna International Group, LLP	1,110,751	30 Mar 2021	0.91%	6,720,043
Principal Financial Group, Inc.	797,064	30 Mar 2021	0.65%	4,822,237
Northern Trust Corporation	737,210	30 Mar 2021	0.60%	4,460,120
Charles Schwab Investment Management, Inc.	657,916	30 Mar 2021	0.54%	3,980,391
Citigroup Inc.	607,981	30 Mar 2021	0.50%	3,678,285
Thrivent Financial For Lutherans	560,322	30 Mar 2021	0.46%	3,389,948

Holder	Shares	Date reported	% out	Value
SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF	7,631,394	29 Apr 2021	6.24%	82,266,427
Vanguard Total Stock Market Index Fund	3,126,627	30 Mar 2021	2.56%	18,916,093
Vanguard Extended Market Index Fund	1,634,550	30 Mar 2021	1.34%	9,889,027
iShares Russell 2000 ETF	1,291,765	30 Mar 2021	1.06%	7,815,178
Fidelity Extended Market Index Fund	587,237	30 Mar 2021	0.48%	3,552,783
Direxion Shares ETF Tr-Direxion Daily S&P Biotech Bull 3x Sh	492,784	30 May 2021	0.40%	3,262,230
Schwab Strategic Tr-Schwab U.S. Small Cap ETF	425,528	27 Feb 2021	0.35%	3,042,525
iShares Russell 2000 Growth ETF	395,626	30 Mar 2021	0.32%	2,393,537
Fidelity Small Cap Index Fund	355,517	30 Jan 2021	0.29%	4,259,093
iShares Genomics Immunology and Healthcare ETF	241,174	30 Mar 2021	0.20%	1,459,102

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