Insider	Transaction	Type	Value	Date	Shares
HARSCH MUTYA FONTE General Counsel	Stock Award(Grant) at price 0.00 per share.	Direct	0	29 Dec 2023	62,500
STUART IAIN A Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	29 Dec 2023	62,500
DOMZALSKI DAVID T Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	29 Dec 2023	225,000
ZERONDA TYLER Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	29 Dec 2023	62,500
HARSCH MUTYA FONTE General Counsel	Stock Award(Grant) at price 0.00 per share.	Direct	0	13 Dec 2023	62,500
STUART IAIN A Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	13 Dec 2023	62,500
DOMZALSKI DAVID T Chief Executive Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	13 Dec 2023	225,000
ZERONDA TYLER Chief Financial Officer	Stock Award(Grant) at price 0.00 per share.	Direct	0	13 Dec 2023	62,500
DOMZALSKI DAVID T Chief Executive Officer	Stock Award(Grant) at price 2.81 per share.	Direct	6,426	30 Nov 2023	2,284
LEPORE PATRICK G Director	Purchase at price 3.91 per share.	Direct	50,778	15 Nov 2023	13,000
HARSCH MUTYA FONTE General Counsel	Stock Award(Grant) at price 6.29 per share.	Direct	23,047	31 May 2023	3,664
DOMZALSKI DAVID T Chief Executive Officer	Stock Award(Grant) at price 6.29 per share.	Direct	17,398	31 May 2023	2,766
LEPORE PATRICK G Director	Purchase at price 2.48 per share.	Direct	49,680	20 Mar 2023	20,000
HARSCH MUTYA FONTE General Counsel	Purchase at price 2.50 per share.	Direct	25,000	20 Mar 2023	10,000
DOMZALSKI DAVID T Chief Executive Officer	Stock Award(Grant) at price 0.20 per share.	Direct	6,861	30 Nov 2022	34,705
DOMZALSKI DAVID T Chief Executive Officer	Stock Award(Grant) at price 0.35 per share.	Direct	4,116	31 May 2022	11,887
ZERONDA TYLER Chief Financial Officer	Stock Award(Grant) at price 0.35 per share.	Direct	4,332	31 May 2022	12,510
HARSCH MUTYA FONTE General Counsel		Direct		17 Mar 2022	75,000
STUART IAIN A Officer		Direct		17 Mar 2022	75,000
DOMZALSKI DAVID T Chief Executive Officer		Direct		17 Mar 2022	312,302
ZERONDA TYLER Chief Financial Officer		Direct		17 Mar 2022	75,000
LEPORE PATRICK G Director	Purchase at price 1.02 per share.	Direct	12,699	30 Nov 2021	12,500
DOMZALSKI DAVID T Chief Executive Officer	Stock Award(Grant) at price 0.88 per share.	Direct	4,119	30 Nov 2021	4,705
ZERONDA TYLER Chief Financial Officer	Stock Award(Grant) at price 0.88 per share.	Direct	3,666	30 Nov 2021	4,187
HARSCH MUTYA FONTE General Counsel		Direct		02 Sept 2021	60,859
STUART IAIN A Officer		Direct		02 Sept 2021	60,859
DOMZALSKI DAVID T Chief Executive Officer		Direct		02 Sept 2021	320,312
ZERONDA TYLER Chief Financial Officer		Direct		02 Sept 2021	60,859
LEPORE PATRICK G Director	Purchase at price 1.60 per share.	Direct	20,000	25 Aug 2021	12,500
PERCEPTIVE ADVISORS, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Sale at price 1.74 per share.	Indirect	435,000	16 Aug 2021	250,000
PERCEPTIVE ADVISORS, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Sale at price 1.84 per share.	Indirect	460,000	13 Aug 2021	250,000
PERCEPTIVE ADVISORS, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Sale at price 2.23 per share.	Indirect	755,740	12 Aug 2021	338,897
SAIK ANDREW Chief Financial Officer	Stock Award(Grant) at price 3.36 per share.	Direct	10,130	28 May 2021	3,017
DOMZALSKI DAVID T Chief Executive Officer	Stock Award(Grant) at price 3.36 per share.	Direct	3,159	28 May 2021	941
LEPORE PATRICK G Director	Purchase at price 3.60 per share.	Direct	44,958	26 May 2021	12,500
PERCEPTIVE ADVISORS, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Sale at price 3.67 per share.	Indirect	3,670,000	06 May 2021	1,000,000
LEPORE PATRICK G Director	Purchase at price 7.41 per share.	Direct	92,562	15 Mar 2021	12,500
SAIK ANDREW Chief Financial Officer		Direct		22 Feb 2021	29,213
HARSCH MUTYA FONTE General Counsel		Direct		22 Feb 2021	29,213
STUART IAIN A Officer		Direct		22 Feb 2021	29,213
DOMZALSKI DAVID T Chief Executive Officer		Direct		22 Feb 2021	153,750
WILEY MATTHEW T Officer		Direct		22 Feb 2021	27,675
PERCEPTIVE ADVISORS, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Purchase at price 2.37 per share.	Indirect	9,999,999	28 Jan 2021	4,219,409
LEPORE PATRICK G Director	Purchase at price 1.71 per share.	Direct	85,425	03 Dec 2020	50,000
HARSCH MUTYA FONTE General Counsel	Stock Award(Grant) at price 1.45 per share.	Direct	15,115	30 Nov 2020	10,460
DOMZALSKI DAVID T Chief Executive Officer	Stock Award(Grant) at price 1.45 per share.	Direct	6,160	30 Nov 2020	4,263
WILEY MATTHEW T Officer	Stock Award(Grant) at price 1.45 per share.	Direct	11,326	30 Nov 2020	7,838
SAIK ANDREW Chief Financial Officer	Purchase at price 1.46 per share.	Direct	58,480	08 Sept 2020	40,000
DOMZALSKI DAVID T Chief Executive Officer	Purchase at price 1.38 per share.	Direct	103,568	08 Sept 2020	75,000
BARBARI SHARON SURREY A Director	Conversion of Exercise of derivative security at price 1.48 per share.	Direct	111,000	20 Aug 2020	75,000
PERCEPTIVE ADVISORS, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Purchase at price 1.85 per share.	Indirect	4,999,999	09 Jun 2020	2,702,702
SAIK ANDREW Chief Financial Officer		Direct		06 May 2020	250,000
HARSCH MUTYA FONTE General Counsel		Direct		06 May 2020	150,000
STUART IAIN A Officer		Direct		06 May 2020	112,500
DOMZALSKI DAVID T Chief Executive Officer		Direct		06 May 2020	680,000
WILEY MATTHEW T Officer		Direct		06 May 2020	150,000
BASTA STEVEN L Director		Direct		03 Apr 2020	14,499
BRUNO ANTHONY D Director		Direct		03 Apr 2020	90,623
HIRSCH STANLEY Director		Indirect		03 Apr 2020	355,643
HARSCH MUTYA FONTE General Counsel		Direct		03 Apr 2020	118,683
STUART IAIN A Officer		Direct		03 Apr 2020	125,212
DOMZALSKI DAVID T Chief Executive Officer		Direct		03 Apr 2020	391,489
WILEY MATTHEW T Officer		Direct		03 Apr 2020	137,824
SAIK ANDREW Chief Financial Officer		Direct		23 Mar 2020	50,000
BASTA STEVEN L Director		Direct		09 Mar 2020	7,108
BRUNO ANTHONY D Director		Direct		09 Mar 2020	44,433
HIRSCH STANLEY Director		Indirect		09 Mar 2020	174,376
HARSCH MUTYA FONTE General Counsel		Direct		09 Mar 2020	58,191
STUART IAIN A Officer		Direct		09 Mar 2020	61,392
DOMZALSKI DAVID T Chief Executive Officer		Direct		09 Mar 2020	191,952
HADAR ILAN Chief Financial Officer		Direct		09 Mar 2020	77,351
WILEY MATTHEW T Officer		Direct		09 Mar 2020	67,576
BASTA STEVEN L Chief Executive Officer		Direct		11 Dec 2019	252,800
BASTA STEVEN L Chief Executive Officer		Direct		11 Dec 2019	252,800
BALL KRISTINE M Chief Financial Officer		Direct		11 Dec 2019	80,300
BALL KRISTINE M Chief Financial Officer		Direct		11 Dec 2019	80,300
KRASNOW RONALD A General Counsel		Direct		11 Dec 2019	24,090
KWON PAUL S. M.D. Officer		Direct		11 Dec 2019	80,300
KWON PAUL S. M.D. Officer		Direct		11 Dec 2019	80,300
WHITCUP SCOTT M Director	Conversion of Exercise of derivative security at price 1.83 per share.	Direct	45,858	14 Jan 2019	25,000
PRESIDIO PARTNERS 2007, L.P. Unknown	Sale at price 7.65 per share.	Indirect	3,825,000	24 Jul 2018	500,000
PRESIDIO PARTNERS 2007 GP, L.P. Unknown	Sale at price 7.65 per share.	Indirect	3,825,000	24 Jul 2018	500,000
PRESIDIO PARTNERS 2007, L.P. Beneficial Owner of more than 10% of a Class of Security		Indirect		29 Jan 2018	1,004,765
CHA ALBERT Director		Indirect		29 Jan 2018	3,717,118
REMEDITEX VENTURES, L.L.C. Beneficial Owner of more than 10% of a Class of Security		Direct		29 Jan 2018	1,178,809
VIVO CAPITAL VIII, L.L.C. Beneficial Owner of more than 10% of a Class of Security		Indirect		29 Jan 2018	3,717,118
FMR LLC Unknown		Indirect		29 Jan 2018	1,118,054
VENBIO GLOBAL STRATEGIC FUND, II, L.P Beneficial Owner of more than 10% of a Class of Security		Direct		29 Jan 2018	1,196,552
CHA ALBERT Director	Purchase at price 17.00 per share.	Indirect	5,000,006	25 Jan 2018	294,118
REMEDITEX VENTURES, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Purchase at price 17.00 per share.	Direct	1,700,000	25 Jan 2018	100,000
VIVO CAPITAL VIII, L.L.C. Beneficial Owner of more than 10% of a Class of Security	Purchase at price 17.00 per share.	Indirect	5,000,006	25 Jan 2018	294,118
VENBIO GLOBAL STRATEGIC FUND, II, L.P Beneficial Owner of more than 10% of a Class of Security	Purchase at price 28.71 per share.	Direct	7,608,150	25 Jan 2018	265,000

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Insider transactions

Insider transactions reported - last two years

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