Carlo Ancelotti’s side suffered a major blow in their pursuit of a top-four finish last time out, having been held to a held to a goalless draw by Aston Villa earlier this week.
The Toffees remain very much in the hunt for European football next season, though, and are just two points adrift of sixth-placed West Ham, who occupy the last Europa League spot. With the introduction of the Europa Conference League next season, a seventh-placed finish would still be enough for Everton, with only goal difference separating them from Tottenham as it stands.
Sheffield United, meanwhile, have been fighting purely for pride for quite a while now, with their relegation to the Championship sealed. The Blades are coming off back-to-back defeats and have won just five matches all season, but will still hope to throw the Toffees plans into disarray.
Here is everything you need to know:
When is it and what time does it start?
The match will get underway at 7pm on Sunday 16 May at Goodison Park.
How can I watch it online and on TV?
The match will be broadcast live on BT Sport 1 and the BT Sport App, with coverage beginning at 6.30pm.
Everton: Pickford; Coleman, Holgate, Keane, Godfrey, Digne; Rodriguez, Doucoure, Allan; Richarlison, Calvert-Lewin
Sheffield United: Ramsdale; Basham, Egan, Robinson; Baldock, Fleck, Norwood, Osborn, Stevens; McGoldrick, Jebbison
What are the odds?
Everton - 2/5
Draw - 18/5
Sheffield United - 7/1