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ProQR Announces Third Quarter 2022 Operating and Financial Results

ProQR Therapeutics N.V.
ProQR Therapeutics N.V.
  • Development of Axiomer® RNA base editing technology platform continues across multiple therapeutic areas; initial pipeline targets to be disclosed in early 2023 with Analyst and Investor R&D event to be held in Q1 2023

  • Management Team appointments and planned additions to the Supervisory Board further strengthen leadership

  • Repayment of debt with cash runway into 2026

LEIDEN, Netherlands & CAMBRIDGE, Mass., Nov. 09, 2022 (GLOBE NEWSWIRE) -- ProQR Therapeutics N.V. (Nasdaq: PRQR) (the “Company”), a company dedicated to changing lives through the creation of transformative RNA therapies, today reported its financial and operating results for the third quarter ended September 30, 2022, and provided a business update.

Axiomer® Program and Business Operations Updates

Axiomer Program

  • In August, ProQR announced the Company will focus exclusively on the development of its Axiomer RNA editing technology platform across multiple therapeutic areas with an initial focus on liver and CNS. The Company also announced it is seeking a strategic partner for its ophthalmology assets.

  • ProQR continues to execute on its global licensing and research partnership with Eli Lilly, focused on the discovery, development, and commercialization of potential new medicines for genetic disorders in the liver and nervous system, and may selectively enter additional partnerships designed to advance and capture the full potential value of the platform.

  • In November, the Company plans to present its proprietary RNA base-editing Axiomer technology at the Oligonucleotide and Peptide Therapeutics EUROPE conference.

Presentation title: Progress on Development of RNA Base Editing Technologies for Precision Medicines

Date: November 18, 2022 at 2:30pm CET

  • ProQR will announce its initial Axiomer pipeline targets in early 2023 and will host an analyst and investor R&D event in Q1 2023.

Business Operations

  • Management Team appointments and Supervisory Board nominations and updates:

    • In October, Jurriaan Dekkers was appointed to the Company’s Management Team as Chief Financial Officer where he leads ProQR’s finance function. He brings to the role more than 20 years of experience in finance, management and leadership roles in biopharma and healthcare companies, as well as in audit and consulting services. Prior to joining ProQR he most recently served as CFO of AstraZeneca in the Netherlands and CEO of Acerta Pharma (part of the AstraZeneca Group). Mr. Dekkers is a Supervisory Board member at ‘Stichting Kinderpostzegels’ in the Netherlands.

    • Also in October, Sheila Sponselee was appointed to the Management Team as VP, Head of People and Operations where she leads Human Resources, Recruitment, Information Technology, and Facilities. Ms. Sponselee joined ProQR in 2020 as VP of Human Resources and has more than 15 years of experience in human resources, recruitment, and operations across varied industries, including information technology and biopharma. Prior to joining ProQR, she most recently led Human Resources at MyTomorrows in the Netherlands. Ms. Sponselee studied human resource management at the University of Applied Science (BSc) and completed leadership programs at IMD Business School for Management and Leadership.

    • Begoña Carreño, PhD, will be nominated for election to the Supervisory Board at the next Annual General Meeting of Shareholders. Dr. Carreño was most recently Global Business Development & Licensing Head (BD&L) in the Ophthalmology franchise at Novartis Pharma, AG, based in Basel, Switzerland.  She has more than 20 years of pharmaceutical development and strategy leadership, having led BD&L efforts at Novartis across five different therapeutic franchises, as well as a proven track record in licensing deals and M&A. Before joining Novartis, she was the Head of External Pharmaceutical projects at Almirall (Barcelona, Spain). Dr. Carreño holds a PhD in Drug Delivery from the London School of Pharmacy (UK) and a BSc in Biochemistry from Keele University (UK).  In anticipation of her election to the Supervisory Board she will join all meetings as member-elect effective immediately.

    • Theresa Heggie will be nominated for election to the Supervisory Board at the next Annual General Meeting of Shareholders. In light of her anticipated re-election to the Supervisory Board, Ms. Heggie departed from the Management Team at the end of October, where she served as the Chief Operating Officer, after originally joining the Management Team in 2021 as the Chief Commercial Officer. Prior to ProQR, she served as Chief Executive Officer of Freeline Therapeutics. She had senior commercial and operating roles at Alnylam Pharmaceuticals as Senior Vice President, Head of CEMEA and Shire where she built the EMEA rare disease business. Earlier in her career, Ms. Heggie held increasingly senior positions in the commercial organizations at Janssen Pharmaceuticals and Baxter Healthcare. She previously served on the ProQR Supervisory Board from 2019-2021. In anticipation of her re-election to the Supervisory Board, she will join all meetings as member-elect effective immediately.

    • Antoine Papiernik,  Chairman and Managing Partner at Sofinnova Partners, has indicated his planned rotation off the ProQR Supervisory Board at the next Annual General Meeting of Shareholders. He has served on ProQR’s Supervisory Board since 2014.

“During the third quarter and in line with our corporate strategy update earlier this year, we focused the business exclusively on the development of our Axiomer RNA base editing technology platform,” said Daniel A. de Boer, Chief Executive Officer of ProQR Therapeutics. “Over the course of the next several months, we will be providing additional details about the progress we have made advancing Axiomer, including our presentation at TIDES Europe later this month, disclosure of our pipeline targets in early 2023, and during an R&D event in late Q1 2023. We also continue to execute on our global licensing and research partnership with Eli Lilly and may selectively enter into additional partnerships to further advance and capture the full potential value of the platform.”

De Boer continued: “To further support our focus on Axiomer, we are pleased to share several updates to our Management Team and Supervisory Board. I welcome Jurriaan and Sheila to the Management Team, and look forward to Theresa and Begoña joining the Supervisory Board. Each brings tremendous experience in relevant areas to support the Company in this next phase of our evolution. In light of his planned departure mid next year at the AGM, I also want to thank Antoine for his important contributions as a Supervisory Board member over the last 8 year. With robust science, leading IP, an experienced team, and a strong balance sheet with cash runway into 2026, we are well resourced to continue to support the advancement of our proprietary platform and pipeline.”

  • In September 2022, ProQR repaid its loan balance with Pontifax Ventures and Kreos Capital, terminating its convertible debt financing agreement.

  • In November 2022, ProQR received formal notice that the Listing Qualifications Staff of The Nasdaq Stock Market has granted the Company an additional 180-day compliance period, through May 1, 2023, to regain compliance with the $1.00 bid price requirement for continued listing on The Nasdaq Capital Market.

Financial Highlights

At September 30, 2022, ProQR held cash and cash equivalents of €100.4 million following full repayment of its convertible debt financing agreement with Pontifax Ventures and Kreos Capital in September 2022, compared to €187.5 million at December 31, 2021. Net cash used in operating activities during the three-month period ended September 30, 2022 was €15.4 million, compared to €8.1 million for the same period last year.

Research and development costs were €15.4 million for the quarter ended September 30, 2022, compared to €11.1 million for the same period last year. General and administrative costs were €5.4 million for the quarter ended September 30, 2022 compared to €4.6 million for the same period last year.

Net loss for the three-month period ended September 30, 2022 was €24.4 million or €0.34 per share, compared to a €15.1 million loss or €0.22 per share for the same period last year.

For further financial information for the period ended September 30, 2022, please refer to the financial statements appearing at the end of this release.

About ProQR

ProQR Therapeutics is dedicated to changing lives through the creation of transformative RNA therapies. ProQR is pioneering a next-generation RNA technology called Axiomer®, which uses a cell’s own editing machinery called ADAR to make specific single nucleotide edits in RNA to reverse a mutation or modulate protein expression and could potentially yield a new class of medicines for genetic diseases. Based on our unique proprietary RNA repair platform technologies we are growing our pipeline with patients and loved ones in mind.

Learn more about ProQR at www.proqr.com.

FORWARD-LOOKING STATEMENTS

This press release contains forward-looking statements. All statements other than statements of historical fact are forward-looking statements, which are often indicated by terms such as "anticipate," "believe," "could," "estimate," "expect," "goal," "intend," "look forward to", "may," "plan," "potential," "predict," "project," "should," "will," "would" and similar expressions. Such forward-looking statements include, but are not limited to, statements regarding the potential of our technologies and platforms (including Axiomer®), our other programs and business operations, our current and planned partnerships and collaborators and the intended benefits thereof, the planned changes to our Supervisory Board, our updated strategic plans and the intended benefits thereof, our continued listing on The Nasdaq Capital Market, and our financial position and cash runway. Forward-looking statements are based on management's beliefs and assumptions and on information available to management only as of the date of this press release. Our actual results could differ materially from those anticipated in these forward-looking statements for many reasons, including, without limitation, the risks, uncertainties and other factors in our filings made with the Securities and Exchange Commission, including certain sections of our annual report filed on Form 20-F. These risks and uncertainties include, among others, the cost, timing and results of preclinical studies and other development activities by us and our collaborative partners whose operations and activities may be slowed or halted by shortage and pressure on supply and logistics on the global market; our reliance on contract manufacturers to supply materials for research and development and the risk of supply interruption or delays from suppliers and/or contract manufacturers; the ability to secure, maintain and realize the intended benefits of collaborations with partners; the possible impairment of, inability to obtain, and costs to obtain intellectual property rights; possible safety or efficacy concerns that could emerge as new data are generated in research and development; the possibility that we will not be able to regain compliance with or effectuate a reversed stock split to regain compliance with Nasdaq’s Minimum Bid Price Requirement, or maintain compliance with any of the other Nasdaq continued listing requirements. general business, operational, financial and accounting risks; and risks related to litigation and disputes with third parties. Given these risks, uncertainties and other factors, you should not place undue reliance on these forward-looking statements, and we assume no obligation to update these forward-looking statements, even if new information becomes available in the future, except as required by law.

Cautionary note on future updates

The statements contained in this press release reflect our current views with respect to future events. Accordingly, we do not undertake and specifically disclaim any obligation to update any forward-looking statements.

ProQR Therapeutics N.V.

Investor contact:
Sarah Kiely
ProQR Therapeutics N.V.
T: +1 617 599 6228
skiely@proqr.com
or
Hans Vitzthum
LifeSci Advisors
T: +1 617 430 7578
hans@lifesciadvisors.com

Media contact:
Robert Stanislaro
FTI Consulting
T: +1 212 850 5657
robert.stanislaro@fticonsulting.com

PROQR THERAPEUTICS N.V.
Unaudited Condensed Consolidated Statement of Financial Position

 

 

 

 

 

 

 

September 30, 

 

December 31, 

 

  

2022

    

2021

 

 

€ 1,000

 

€ 1,000

Assets

 

  

 

  

Current assets

 

  

 

  

Cash and cash equivalents

 

100,431

 

187,524

Prepayments and other receivables

 

3,104

 

3,404

Other taxes

 

570

 

555

 

 

 

 

 

Total current assets

 

104,105

 

191,483

 

 

 

 

 

Property, plant and equipment

 

17,007

 

17,467

Investments in associates

 

 

8

Investments in financial assets

 

621

 

621

 

 

 

 

 

Total assets

 

121,733

 

209,579

 

 

 

 

 

Equity and liabilities

 

  

 

  

Equity

 

 

 

  

Equity attributable to owners of the Company

 

64,921

 

113,833

Non-controlling interests

 

(381)

 

(604)

Total equity

 

64,540

 

113,229

 

 

 

 

 

Current liabilities

 

  

 

  

Borrowings

 

1,888

 

4,771

Lease liabilities

 

1,370

 

1,534

Derivative financial instruments

 

144

 

3,995

Trade payables

 

425

 

191

Current income tax liability

 

 

Social securities and other taxes

 

824

 

1,230

Deferred income

 

8,624

 

5,115

Other current liabilities

 

13,697

 

10,760

 

 

 

 

 

Total current liabilities

 

26,972

 

27,596

 

 

 

 

 

Borrowings

 

4,770

 

39,319

Lease liabilities

 

14,190

 

14,748

Deferred income

 

11,261

 

14,687

 

 

 

 

 

Total liabilities

 

57,193

 

96,350

 

 

 

 

 

Total equity and liabilities

 

121,733

 

209,579

PROQR THERAPEUTICS N.V.
Unaudited Condensed Consolidated Statement of Profit or Loss and OCI
(€ in thousands, except share and per share data)

 

 

 

 

 

 

 

 

 

 

 

Three month period

 

Nine month period

 

 

ended September 30, 

 

ended September 30, 

 

    

2022

 

2021

 

2022

 

2021

 

 

€ 1,000

 

€ 1,000

 

€ 1,000

 

€ 1,000

Revenue

 

956

 

872

 

3,215

 

1,115

 

 

 

 

 

 

 

 

 

Other income

 

74

 

286

 

274

 

838

 

 

 

 

 

 

 

 

 

Research and development costs

 

(15,352)

 

(11,124)

 

(40,168)

 

(29,764)

General and administrative costs

 

(5,359)

 

(4,591)

 

(15,679)

 

(12,052)

Total operating costs

 

(20,711)

 

(15,715)

 

(55,847)

 

(41,816)

 

 

  

 

  

 

  

 

  

Operating result

 

(19,681)

 

(14,557)

 

(52,358)

 

(39,863)

Finance income and expense

 

(620)

 

266

 

(1,998)

 

(2,491)

Results related to associates

 

 

(132)

 

(8)

 

(132)

Gain on disposal of associate

 

 

 

 

514

Results related to derecognition of financial liabilities

 

(4,016)

 

 

(2,872)

 

Results related to financial liabilities measured at fair value through profit or loss

 

5

 

(611)

 

3,831

 

(1,373)

 

 

  

 

  

 

  

 

  

Result before corporate income taxes

 

(24,312)

 

(15,034)

 

(53,405)

 

(43,345)

Income taxes

 

(69)

 

(35)

 

(96)

 

(95)

 

 

  

 

  

 

  

 

  

Result for the period

 

(24,381)

 

(15,069)

 

(53,501)

 

(43,440)

Other comprehensive income (foreign exchange differences on foreign operation)

 

612

 

206

 

1,523

 

461

 

 

  

 

  

 

  

 

  

Total comprehensive income

 

(23,769)

 

(14,863)

 

(51,978)

 

(42,979)

 

 

 

 

 

 

 

 

 

Result attributable to

 

  

 

  

 

  

 

  

Owners of the Company

 

(24,395)

 

(15,047)

 

(53,724)

 

(43,400)

Non-controlling interests

 

14

 

(22)

 

223

 

(40)

 

 

(24,381)

 

(15,069)

 

(53,501)

 

(43,440)

Total comprehensive income attributable to

 

 

 

 

 

 

 

 

Owners of the Company

 

(23,783)

 

(14,841)

 

(52,201)

 

(42,939)

Non-controlling interests

 

14

 

(22)

 

223

 

(40)

 

 

(23,769)

 

(14,863)

 

(51,978)

 

(42,979)

 

 

  

 

  

 

  

 

  

Share information

 

  

 

  

 

  

 

  

Weighted average number of shares outstanding1

 

71,382,837

 

68,263,034

 

71,367,459

 

61,804,367

 

 

 

 

 

 

 

 

 

Earnings per share attributable to owners of the Company (Euro per share)

 

 

 

 

 

 

 

 

Basic loss per share1

 

(0.34)

 

(0.22)

 

(0.75)

 

(0.70)

Diluted loss per share1

 

(0.34)

 

(0.22)

 

(0.75)

 

(0.70)

  1. For these periods the potential exercise of share options is not included in the diluted earnings per share as the Company was loss-making. Due to the anti-dilutive nature of the outstanding options, basic and diluted earnings per share are equal.

PROQR THERAPEUTICS N.V.
Unaudited Condensed Consolidated Statement of Changes in Equity

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Attributable to owners of the Company

 

 

 

 

 

  

Number
of shares

  

Share
Capital

  

Share
Premium

  

Equity settled
Employee
Benefit
Reserve

  

Option
premium on
convertible
loan

  

Translation
Reserve

  

Accumulated
Deficit

  

Total

  

Non-
controlling
interests

  

Total
Equity

 

 

  

 

€ 1,000

 

€ 1,000

 

€ 1,000

 

€ 1,000

 

€ 1,000

 

€ 1,000

 

€ 1,000

 

€ 1,000

 

€ 1,000

Balance at January 1, 2021

 

54,131,553

 

2,165

 

288,757

 

23,825

 

280

 

(189)

 

(257,747)

 

57,091

 

(545)

 

56,546

Result for the period

 

 

 

 

 

 

 

(43,400)

 

(43,400)

 

(40)

 

(43,440)

Other comprehensive income

 

 

 

 

 

 

461

 

 

461

 

 

461

Recognition of share-based payments

 

112,657

 

5

 

382

 

4,435

 

 

 

 

4,822

 

 

4,822

Issuance of ordinary shares

 

20,498,451

 

820

 

107,657

 

 

 

 

 

108,477

 

 

108,477

Treasury shares transferred

 

(217,933)

 

 

 

 

 

 

 

 

 

Share options lapsed

 

 

 

 

(391)

 

 

 

391

 

 

 

Share options exercised

 

338,653

 

5

 

1,150

 

(821)

 

 

 

821

 

1,155

 

 

1,155

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Balance at September 30, 2021

 

74,863,381

 

2,995

 

397,946

 

27,048

 

280

 

272

 

(299,935)

 

128,606

 

(585)

 

128,021

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Balance at January 1, 2022

 

74,865,381

 

2,995

 

398,309

 

28,443

 

1,426

 

430

 

(317,770)

 

113,833

 

(604)

 

113,229

Result for the period

 

 

 

 

 

 

 

(53,724)

 

(53,724)

 

223

 

(53,501)

Other comprehensive income

 

 

 

 

 

 

1,523

 

 

1,523

 

 

1,523

Recognition of share-based payments

 

 

 

 

3,256

 

 

 

 

3,256

 

 

3,256

Issuance of ordinary shares

 

 

 

 

 

 

 

 

 

 

Treasury shares transferred

 

(143,094)

 

 

 

 

 

 

 

 

 

Share options lapsed

 

 

 

 

(647)

 

 

 

647

 

 

 

Share options exercised / RSUs vested

 

143,094

 

 

33

 

(362)

 

 

 

362

 

33

 

 

33

 

 

  

 

  

 

  

 

  

 

  

 

  

 

  

 

  

 

  

 

  

Balance at September 30, 2022

 

74,865,381

 

2,995

 

398,342

 

30,690

 

1,426

 

1,953

 

(370,485)

 

64,921

 

(381)

 

64,540

PROQR THERAPEUTICS N.V.
Unaudited Condensed Consolidated Statement of Cash Flows

 

 

 

 

 

 

 

 

 

 

 

Three month period 

 

Nine month period 

 

 

ended September 30, 

 

ended September 30, 

 

 

 

 

 

 

 

 

 

 

    

2022

 

2021

 

2022

 

2021

 

 

€ 1,000

 

€ 1,000

 

€ 1,000

 

€ 1,000

Cash flows from operating activities

 

  

 

  

 

  

 

  

Net result

 

(24,381)

 

(15,069)

 

(53,501)

 

(43,440)

Adjustments for:

 

 

 

 

 

 

 

 

— Depreciation

 

612

 

544

 

1,773

 

1,777

— Share-based compensation

 

1,335

 

1,716

 

3,256

 

4,435

— Financial income and expenses

 

620

 

(266)

 

1,998

 

2,491

— Results related to associates

 

 

132

 

8

 

132

— Gain on disposal of associate

 

 

 

 

(514)

— Results related to financial liabilities measured at fair value through profit or loss

 

(5)

 

611

 

(3,831)

 

1,373

— Result related to derecognition of financial liabilities

 

4,016

 

 

2,872

 

— Income tax expenses

 

69

 

35

 

96

 

95

 

 

 

 

 

 

 

 

 

Changes in working capital

 

3,465

 

4,836

 

231

 

5,658

Cash used in operations

 

(14,269)

 

(7,461)

 

(47,098)

 

(27,993)

 

 

  

 

  

 

  

 

  

Corporate income tax paid

 

(69)

 

(35)

 

(96)

 

(95)

Interest received

 

67

 

 

67

 

5

Interest paid

 

(1,093)

 

(561)

 

(3,548)

 

(1,714)

 

 

  

 

  

 

  

 

  

Net cash used in operating activities

 

(15,364)

 

(8,057)

 

(50,675)

 

(29,797)

 

 

  

 

  

 

  

 

  

Cash flow from investing activities

 

 

 

 

 

 

 

 

Purchases of property, plant and equipment

 

(246)

 

(175)

 

(721)

 

(259)

 

 

  

 

  

 

  

 

  

Net cash used in investing activities

 

(246)

 

(175)

 

(721)

 

(259)

 

 

  

 

  

 

  

 

  

Cash flow from financing activities

 

  

 

  

 

  

 

  

Proceeds from issuance of shares, net of transaction costs

 

 

23,223

 

 

108,477

Proceeds from exercise of share options

 

 

402

 

33

 

1,155

Proceeds from borrowings

 

 

284

 

 

853

Repayment of convertible loans

 

(43,373)

 

 

(43,373)

 

Repayment of lease liability

 

(381)

 

(347)

 

(1,314)

 

(597)

 

 

  

 

  

 

  

 

  

Net cash (used in)/generated by financing activities

 

(43,754)

 

23,562

 

(44,654)

 

109,888

 

 

  

 

  

 

  

 

  

Net increase (decrease) in cash and cash equivalents

 

(59,364)

 

15,330

 

(96,050)

 

79,832

 

 

  

 

  

 

  

 

  

Currency effect cash and cash equivalents

 

3,393

 

1,369

 

8,957

 

471

Cash and cash equivalents, at beginning of the period

 

156,402

 

139,442

 

187,524

 

75,838

 

 

  

 

  

 

  

 

  

Cash and cash equivalents at the end of the period

 

100,431

 

156,141

 

100,431

 

156,141